Browsing HMS Scholarly Articles by Keyword "Chemotherapy and Drug Treatment"

Now showing items 1-10 of 10

    • Concurrent Chemoradiation for Vaginal Cancer 

      Miyamoto, David T.; Viswanathan, Akila N. (Public Library of Science, 2013)
      Background: It is not known whether the addition of chemotherapy to radiation therapy improves outcomes in primary vaginal cancer. Here, we review clinical outcomes in patients with primary vaginal cancer treated with ...

    • Differential Disruption of EWS-FLI1 Binding by DNA-Binding Agents 

      Chen, Changmin; Wonsey, Diane R.; Lemieux, Madeleine E.; Kung, Andrew L. (Public Library of Science, 2013)
      Fusion of the EWS gene to FLI1 produces a fusion oncoprotein that drives an aberrant gene expression program responsible for the development of Ewing sarcoma. We used a homogenous proximity assay to screen for compounds ...

    • Icariside II Induces Apoptosis in U937 Acute Myeloid Leukemia Cells: Role of Inactivation of STAT3-Related Signaling 

      Kang, Sang-Hun; Jeong, Soo-Jin; Kim, Sun-Hee; Kim, Ji-Hyun; Koh, Wonil; Kim, Sung-Hoon; Jung, Ji Hoon; Kim, Jung Hyo; Kim, Dae Keun; Chen, Chang-Yan (Public Library of Science, 2012)
      Background: The aim of this study is to determine anti-cancer effect of Icariside II purified from the root of Epimedium koreanum Nakai on human acute myeloid leukemia (AML) cell line U937. Methodology/Principal Findings ...

    • Inhibition of Non-Homologous End Joining Repair Impairs Pancreatic Cancer Growth and Enhances Radiation Response 

      Li, Ying-Hua; Wang, Xiaoxu; Pan, Yunfeng; Lee, Dong-Hyun; Chowdhury, Dipanjan; Kimmelman, Alec C. (Public Library of Science, 2012)
      Pancreatic ductal adenocarcinoma (PDAC) is amongst the deadliest of human cancers, due to its late diagnosis as well as its intense resistance to currently available therapeutics. To identify mechanisms as to why PDAC are ...

    • Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism 

      Liao, Jianqun; Qian, Feng; Tchabo, Nana; Mhawech-Fauceglia, Paulette; Beck, Amy; Qian, Zikun; Wang, Xinhui; Huss, Wendy J.; Lele, Shashikant B.; Morrison, Carl D.; Odunsi, Kunle (Public Library of Science, 2014)
      Cells with sphere forming capacity, spheroid cells, are present in the malignant ascites of patients with epithelial ovarian cancer (EOC) and represent a significant impediment to efficacious treatment due to their putative ...

    • p53 Modulation as a Therapeutic Strategy in Gastrointestinal Stromal Tumors 

      Henze, Joern; Mühlenberg, Thomas; Simon, Susanne; Grabellus, Florian; Rubin, Brian; Taeger, Georg; Schuler, Martin; Treckmann, Juergen; Debiec-Rychter, Maria; Taguchi, Takahiro; Bauer, Sebastian; Fletcher, Jonathan A. (Public Library of Science, 2012)
      The KIT-inhibitor imatinib mesylate (IM) has greatly improved the treatment of metastatic gastrointestinal stromal tumors (GIST). IM exhibits strong antiproliferative effects but fails to induce sufficient levels of apoptosis ...

    • Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells 

      Fowler, Trent; Ghatak, Payel; Price, David H.; Conaway, Ronald; Conaway, Joan; Chiang, Cheng-Ming; Bradner, James E.; Shilatifard, Ali; Roy, Ananda L. (Public Library of Science, 2014)
      High level MYC expression is associated with almost all human cancers. JQ1, a chemical compound that inhibits MYC expression is therapeutically effective in preclinical animal models in midline carcinoma, and Burkitt’s ...

    • United States Acculturation and Cancer Patients’ End-of-Life Care 

      Wright, Alexi Anne; Stieglitz, Heather; Kupersztoch, Yankel M.; Paulk, M. Elizabeth; Kim, Yookyung; Katz, Ingrid Theresa; Munoz, Francisco; Jimenez, Rachel Beth; Mutchler, Jan; Rivera, Lorna; Back, Anthony L.; Prigerson, Holly G (Public Library of Science, 2013)
      Background: Culture shapes how people understand illness and death, but few studies examine whether acculturation influences patients’ end-of-life treatment preferences and medical care. Methods and Findings: In this ...

    • Vascular Disrupting Agent Drug Classes Differ in Effects on the Cytoskeleton 

      Kim, Sujeong; Peshkin, Lenoid; Mitchison, Timothy J. (Public Library of Science, 2012)
      Vascular disrupting agents (VDAs), anti-cancer drugs that target established tumor blood vessels, fall into two main classes: microtubule targeting drugs, exemplified by combretastatin A4 (CA4), and flavonoids, exemplified ...

    • Vorinostat Eliminates Multicellular Resistance of Mesothelioma 3D Spheroids via Restoration of Noxa Expression 

      Barbone, Dario; Cheung, Priscilla; Battula, Sailaja; Busacca, Sara; Gray, Steven G.; Longley, Daniel B.; Bueno, Raphael; Sugarbaker, David John; Bueno, Raphael; Broaddus, V. Courtney (Public Library of Science, 2012)
      When grown in 3D cultures as spheroids, mesothelioma cells acquire a multicellular resistance to apoptosis that resembles that of solid tumors. We have previously found that resistance to the proteasome inhibitor bortezomib ...