Browsing HMS Scholarly Articles by Keyword "Obesity"

Now showing items 1-20 of 81

    • A 600 kb Deletion Syndrome at 16p11.2 Leads to Energy Imbalance and Neuropsychiatric Disorders 

      Zufferey, Flore; Sherr, Elliott H; Beckmann, Noam D; Hanson, Ellen M.; Maillard, Anne M; Hippolyte, Loyse; Macé, Aurélien; Ferrari, Carina; Kutalik, Zoltán; Andrieux, Joris; Aylward, Elizabeth; Barker, Mandy; Bernier, Raphael; Bouquillon, Sonia; Conus, Philippe; Delobel, Bruno; Faucett, W Andrew; Goin-Kochel, Robin P; Grant, Ellen; Harewood, Louise; Hunter, Jill V; Lebon, Sébastien; Ledbetter, David H; Martin, Christa Lese; Männik, Katrin; Martinet, Danielle; Mukherjee, Pratik; Ramocki, Melissa B; Spence, Sarah J; Steinman, Kyle J; Tjernagel, Jennifer; Spiro, John E; Reymond, Alexandre; Beckmann, Jacques S; Chung, Wendy K; Jacquemont, Sébastien (BMJ Publishing Group, 2012)
      Background: The recurrent ∼600 kb 16p11.2 BP4-BP5 deletion is among the most frequent known genetic aetiologies of autism spectrum disorder (ASD) and related neurodevelopmental disorders. Objective: To define the medical, ...

    • Adipokine Hormones and Hand Osteoarthritis: Radiographic Severity and Pain 

      Massengale, Mei; Lu, Bing; Pan, John Jun-Hao; Katz, Jeffrey Neil; Solomon, Daniel Hal (Public Library of Science, 2012)
      Introduction: Obesity's association with hand osteoarthritis cannot be fully explained by mechanical loading. We examined the relationship between adipokines and radiographic hand osteoarthritis severity and pain. Methods: ...

    • Adiponectin Gene Polymorphisms and Acute Respiratory Distress Syndrome Susceptibility and Mortality 

      Ahasic, Amy M.; Zhao, Yang; Su, Li; Sheu, Chau-Chyun; Thompson, B. Taylor; Christiani, David C. (Public Library of Science, 2014)
      Rationale: Adiponectin is an anti-inflammatory adipokine that is the most abundant gene product of adipose tissue. Lower levels have been observed in obesity, insulin resistance, and in critical illness. However, elevated ...

    • Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons 

      Sun, Jia; Gao, Yong; Yao, Ting; Huang, Yiru; He, Zhenyan; Kong, Xingxing; Yu, Kai-jiang; Wang, Rui-tao; Guo, Hongbo; Yan, Jianqun; Chang, Yongsheng; Chen, Hong; Scherer, Philipp E.; Liu, Tiemin; Williams, Kevin W. (Elsevier, 2016)
      Objective: Adiponectin receptors (AdipoRs) are located on neurons of the hypothalamus involved in metabolic regulation – including arcuate proopiomelanocortin (Pomc) and Neuropeptide Y/Agouti-related peptide (NPY/AgRP) ...

    • Adipose Tissue Depots and Their Cross‐Sectional Associations With Circulating Biomarkers of Metabolic Regulation 

      Lee, Jane J.; Britton, Kathryn A.; Pedley, Alison; Massaro, Joseph M.; Speliotes, Elizabeth K.; Murabito, Joanne M.; Hoffmann, Udo; Ingram, Cheryl; Keaney, John F.; Vasan, Ramachandran S.; Fox, Caroline S. (John Wiley and Sons Inc., 2016)
      Background: Visceral adipose tissue (VAT) and fatty liver differ in their associations with cardiovascular risk compared with subcutaneous adipose tissue (SAT). Several biomarkers have been linked to metabolic derangements ...

    • Altered NK cell function in obese healthy humans 

      Laue, Tobias; Wrann, Christiane D; Hoffmann-Castendiek, Birgit; Pietsch, Daniel; Hübner, Lena; Kielstein, Heike (BioMed Central, 2015)
      Background: Obesity is associated with an elevated risk for several types of cancer and thus a major health hazard. However, the mechanism between overweight and cancer susceptibility is still elusive. Leptin, mainly ...

    • Association between Class III Obesity (BMI of 40–59 kg/m2) and Mortality: A Pooled Analysis of 20 Prospective Studies 

      Kitahara, Cari M.; Flint, Alan J.; Berrington de Gonzalez, Amy; Bernstein, Leslie; Brotzman, Michelle; MacInnis, Robert J.; Moore, Steven C.; Robien, Kim; Rosenberg, Philip S.; Singh, Pramil N.; Weiderpass, Elisabete; Adami, Hans Olov; Anton-Culver, Hoda; Ballard-Barbash, Rachel; Buring, Julie E.; Freedman, D. Michal; Fraser, Gary E.; Beane Freeman, Laura E.; Gapstur, Susan M.; Gaziano, John Michael; Giles, Graham G.; Håkansson, Niclas; Hoppin, Jane A.; Hu, Frank B.; Koenig, Karen; Linet, Martha S.; Park, Yikyung; Patel, Alpa V.; Purdue, Mark P.; Schairer, Catherine; Sesso, Howard D.; Visvanathan, Kala; White, Emily; Wolk, Alicja; Zeleniuch-Jacquotte, Anne; Hartge, Patricia (Public Library of Science, 2014)
      Background: The prevalence of class III obesity (body mass index [BMI]≥40 kg/m2) has increased dramatically in several countries and currently affects 6% of adults in the US, with uncertain impact on the risks of illness ...

    • The Association between Disturbed Eating Behavior and Socioeconomic Status: The Online Korean Adolescent Panel Survey (OnKAPS) 

      Lee, Eun Jung; Park, Sangshin; Kim, Cho-il; Choi, Doo-won; Lee, Jung Sun; Oh, Sun Min; Cho, Eunyoung; Park, Hye Kyung; Kwon, Kwang-il; Oh, Sang Woo (Public Library of Science, 2013)
      Background: A limited amount of research, primarily conducted in Western countries, has suggested that higher socioeconomic status (SES) is associated with higher risk of eating disorders (EDs). However, little is known ...

    • The association between phthalates and metabolic syndrome: the National Health and Nutrition Examination Survey 2001–2010 

      James-Todd, Tamarra M.; Huang, Tianyi; Seely, Ellen W.; Saxena, Aditi R. (BioMed Central, 2016)
      Background: Higher exposure to certain phthalates is associated with a diabetes and insulin resistance, with sex differences seen. Yet, little is known about the association between phthalates and metabolic syndrome (MetS), ...

    • Association Between Prolactin and Incidence of Cardiovascular Risk Factors in the Framingham Heart Study 

      Therkelsen, Kate E.; Abraham, Tobin M.; Pedley, Alison; Massaro, Joseph M.; Sutherland, Patrice; Hoffmann, Udo; Fox, Caroline S. (John Wiley and Sons Inc., 2016)
      Background: Prolactin is an anterior pituitary hormone that may modulate the adverse effects of obesity. Prolactin has been associated with cardiovascular disease mortality, but less is known about whether prolactin predicts ...

    • Association between shift work and obesity among female nurses: Korean Nurses’ Survey 

      Kim, Min-Ju; Son, Kuk-Hui; Park, Hyun-Young; Choi, Dong-Ju; Yoon, Chang-Hwan; Lee, Hea-Young; Cho, Eun-Young; Cho, Myeong-Chan (BioMed Central, 2013)
      Background: Shift work has been hypothesized as a risk factor for obesity. In this study, we investigated the association between current shift work and body mass index (BMI) among female nurses in Korea. The relationship ...

    • Associations between Changes in City and Address Specific Temperature and QT Interval - The VA Normative Aging Study 

      Mehta, Amar J.; Kloog, Itai; Zanobetti, Antonella; Coull, Brent A.; Sparrow, David; Vokonas, Pantel; Schwartz, Joel (Public Library of Science, 2014)
      Background: The underlying mechanisms of the association between ambient temperature and cardiovascular morbidity and mortality are not well understood, particularly for daily temperature variability. We evaluated if daily ...

    • Bachelors, Divorcees, and Widowers: Does Marriage Protect Men from Type 2 Diabetes? 

      Cornelis, Marilyn C.; Chiuve, Stephanie E.; Glymour, M. Maria; Chang, Shun-Chiao; Tchetgen Tchetgen, Eric J.; Liang, Liming; Koenen, Karestan C.; Rimm, Eric B.; Kawachi, Ichiro; Kubzansky, Laura D. (Public Library of Science, 2014)
      While research has suggested that being married may confer a health advantage, few studies to date have investigated the role of marital status in the development of type 2 diabetes. We examined whether men who are not ...

    • Beyond type 2 diabetes, obesity and hypertension: an axis including sleep apnea, left ventricular hypertrophy, endothelial dysfunction, and aortic stiffness among Mexican Americans in Starr County, Texas 

      Hanis, Craig L.; Redline, Susan; Cade, Brian E.; Bell, Graeme I.; Cox, Nancy J.; Below, Jennifer E.; Brown, Eric L.; Aguilar, David (BioMed Central, 2016)
      Background: There is an increasing appreciation for a series of less traditional risk factors that should not be ignored when considering type 2 diabetes, obesity, hypertension, and cardiovascular disease. These include ...

    • Body Mass Index and Decline of Cognitive Function 

      Kim, Sujin; Kim, Yongjoo; Park, Sang Min (Public Library of Science, 2016)
      Background: The association between body mass index (BMI) and cognitive function is a public health issue. This study investigated the relationship between obesity and cognitive impairment which was assessed by the Korean ...

    • Body Mass Index, Smoking and Hypertensive Disorders during Pregnancy: A Population Based Case-Control Study 

      Gudnadóttir, Thuridur A.; Bateman, Brian T.; Hernádez-Díaz, Sonia; Luque-Fernandez, Miguel Angel; Valdimarsdottir, Unnur; Zoega, Helga (Public Library of Science, 2016)
      While obesity is an indicated risk factor for hypertensive disorders of pregnancy, smoking during pregnancy has been shown to be inversely associated with the development of preeclampsia and gestational hypertension. The ...

    • The Bright Side and Dark Side of Workplace Social Capital: Opposing Effects of Gender on Overweight among Japanese Employees 

      Kobayashi, Tomoko; Suzuki, Etsuji; Oksanen, Tuula; Kawachi, Ichiro; Takao, Soshi (Public Library of Science, 2014)
      Background: A growing number of studies have sought to examine the health associations of workplace social capital; however, evidence of associations with overweight is sparse. We examined the association between individual ...

    • Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders 

      Kim, So Hun; Plutzky, Jorge (Korean Diabetes Association, 2016)
      Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown ...

    • Census tract based income level and lipid levels in urban pediatric primary care: a retrospective study 

      Martinez, Enid E.; Forbes, Peter W.; O’Brien, Sharon E.; de Ferranti, Sarah D. (BioMed Central, 2016)
      Background: Lower socioeconomic status has been associated with adverse lipid levels in adult populations. Childhood dyslipidemia is a risk factor for future cardiovascular disease. However, studies examining relationships ...

    • Changes in Body Composition over Eight Years in a Randomized Trial of a Lifestyle Intervention: The Look AHEAD Study 

      Pownall, Henry J.; Bray, George A.; Wagenknecht, Lynne E.; Walkup, Michael P.; Heshka, Stanley; Hubbard, Van S.; Hill, James; Kahn, Steven E.; Nathan, David M.; Schwartz, Anne V.; Johnson, Karen C. (2014)
      Objective: To determine the effects of an intensive lifestyle intervention vs. a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. Design and ...