Browsing HMS Scholarly Articles by Keyword "T cell differentiation"
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The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells
(eLife Sciences Publications, Ltd, 2015)The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified ... -
Regulation of T Cell Differentiation and Function by EZH2
(Frontiers Media S.A., 2016)The enhancer of zeste homolog 2 (EZH2), one of the polycomb-group proteins, is the catalytic subunit of Polycomb-repressive complex 2 (PRC2) and induces the trimethylation of the histone H3 lysine 27 (H3K27me3) promoting ...