Browsing HMS Scholarly Articles by Keyword "T cell tolerance"

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    • Allorecognition by T Lymphocytes and Allograft Rejection 

      Marino, Jose; Paster, Joshua; Benichou, Gilles (Frontiers Media S.A., 2016)
      Recognition of donor antigens by recipient T cells in secondary lymphoid organs initiates the adaptive inflammatory immune response leading to the rejection of allogeneic transplants. Allospecific T cells become activated ...

    • The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation 

      Bardhan, Kankana; Anagnostou, Theodora; Boussiotis, Vassiliki A. (Frontiers Media S.A., 2016)
      The immune system maintains a critically organized network to defend against foreign particles, while evading self-reactivity simultaneously. T lymphocytes function as effectors and play an important regulatory role to ...