Browsing HMS Scholarly Articles by Keyword "actionable genes"

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    • Clinical next generation sequencing to identify actionable aberrations in a phase I program 

      Boland, Genevieve M.; Piha-Paul, Sarina A.; Subbiah, Vivek; Routbort, Mark; Herbrich, Shelley M.; Baggerly, Keith; Patel, Keyur P.; Brusco, Lauren; Horombe, Chacha; Naing, Aung; Fu, Siqing; Hong, David S.; Janku, Filip; Johnson, Amber; Broaddus, Russell; Luthra, Raja; Shaw, Kenna; Mendelsohn, John; Mills, Gordon B.; Meric-Bernstam, Funda (Impact Journals LLC, 2015)
      Purpose We determined the frequency of recurrent hotspot mutations in 46 cancer-related genes across tumor histologies in patients with advanced cancer. Methods: We reviewed data from 500 consecutive patients who underwent ...