Browsing HMS Scholarly Articles by Keyword "aging"
Now showing items 1-20 of 63
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Age- and Gender-Associated Differences in Electrical Impedance Values of Skeletal Muscle
(IOP Publishing, 2013)Electrical impedance measurements of skeletal muscle may be sensitive to age-associated declines in muscle health. In an effort to evaluate this concept further, we performed electrical impedance myography (EIM) using a ... -
Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function
(Impact Journals LLC, 2016)Skeletal muscle is a highly regenerative tissue, but muscle repair potential is increasingly compromised with advancing age. In this study, we demonstrate that increased NF-κB activity in aged muscle fibers contributes to ... -
Age-related decline in white matter tract integrity and cognitive performance: A DTI tractography and structural equation modeling study
(Elsevier BV, 2012)Age-related decline in microstructural integrity of certain white matter tracts may explain cognitive decline associated with normal aging. Whole brain tractography and a clustering segmentation in 48 healthy individuals ... -
Age-related striatal BOLD changes without changes in behavioral loss aversion
(Frontiers Media S.A., 2015)Loss aversion (LA), the idea that negative valuations have a higher psychological impact than positive ones, is considered an important variable in consumer research. The literature on aging and behavior suggests older ... -
Aging and emotional expressions: is there a positivity bias during dynamic emotion recognition?
(Frontiers Media S.A., 2015)In this study, we investigated whether age-related differences in emotion regulation priorities influence online dynamic emotional facial discrimination. A group of 40 younger and a group of 40 older adults were invited ... -
Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context
(Public Library of Science, 2009)Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other human ... -
The Aging Kidney: Increased Susceptibility to Nephrotoxicity
(MDPI, 2014)Three decades have passed since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury. Data from these experimental models is strengthened by clinical data ... -
Assessing brain plasticity across the lifespan with transcranial magnetic stimulation: why, how, and what is the ultimate goal?
(Frontiers Media S.A., 2013)Sustaining brain and cognitive function across the lifespan must be one of the main biomedical goals of the twenty-first century. We need to aim to prevent neuropsychiatric diseases and, thus, to identify and remediate ... -
Association Between Comorbidities and Outcomes in Heart Failure Patients With and Without an Implantable Cardioverter-Defibrillator for Primary Prevention
(John Wiley & Sons, Ltd, 2015)Background: Implantable cardioverter-defibrillator (ICD) therapy is associated with improved outcomes in patients with heart failure (HF), but whether this association holds among older patients with multiple comorbid ... -
Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study.
(2004)Because body iron burden is inversely associated with lead absorption, genes associated with hemochromatosis may modify body lead burden. Our objective was to determine whether the C282Y and/or H63D hemochromatosis gene ... -
Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons
(National Institute of Environmental Health Sciences, 2010)Background: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ... -
BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine
(Impact Journals LLC, 2015)Virus-neutralizing antibody and B cell responses to influenza A viruses were measured in 35 aged and 28 middle-aged individuals following vaccination with the 2012 and 2013 trivalent inactivated influenza vaccines. Antibody ... -
Cardiovascular Risk Score, Cognitive Decline, and Dementia in Older Mexican Americans: The Role of Sex and Education
(Blackwell Publishing Ltd, 2013)Background: The purpose of this study was to examine the associations of cardiovascular disease (CVD) risk with cognitive decline and incidence of dementia and cognitive impairment but not dementia (CIND) and the role of ... -
Cathepsin K knockout alleviates aging-induced cardiac dysfunction
(BlackWell Publishing Ltd, 2014)Aging is a major risk factor for cardiovascular disease. It has previously been shown that protein levels of cathepsin K, a lysosomal cysteine protease, are elevated in the failing heart and that genetic ablation of cathepsin ... -
Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity
(eLife Sciences Publications, Ltd, 2016)Mammalian lifespan differs by >100 fold, but the mechanisms associated with such longevity differences are not understood. Here, we conducted a study on primary skin fibroblasts isolated from 16 species of mammals and ... -
Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment
(Lippincott Williams & Wilkins, 2014)Objective(s): HIV-associated neurocognitive disorders (HAND) remain prevalent in HIV-infected patients on antiretroviral therapy (ART), but the underlying mechanisms are unclear. Some features of HAND resemble those of ... -
The Clock-in-the-Box, a brief cognitive screen, is associated with failure to return home in an elderly hospitalized sample
(Dove Medical Press, 2016)Purpose Cognitive screening upon hospital admission can provide important information about the patient’s ability to process information during the inpatient stay. The Clock-in-the-Box (CIB) is a rapidly administered ... -
Cochlear neuropathy and the coding of supra-threshold sound
(Frontiers Media S.A., 2014)Many listeners with hearing thresholds within the clinically normal range nonetheless complain of difficulty hearing in everyday settings and understanding speech in noise. Converging evidence from human and animal studies ... -
Cognitive and Physical Demands of Activities of Daily Living In Older Adults: Validation of Expert Panel Ratings: The SAGES Functional Measures Working Group
(2015)Background: Difficulties with performance of functional activities may result from cognitive and/or physical impairments. To date, there has not been a clear delineation of the physical and cognitive demands of activities ... -
Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy
(BlackWell Publishing Ltd, 2013)Because of its anabolic effects on muscle, testosterone is being explored as a function-promoting anabolic therapy for functional limitations associated with aging; however, concerns about testosterone’s adverse effects ...