Browsing HMS Scholarly Articles by Keyword "amyloid"

Now showing items 1-3 of 3

    • Florbetapir F 18 amyloid PET and 36-month cognitive decline:a prospective multicenter study 

      Doraiswamy, P M; Sperling, R A; Johnson, K; Reiman, E M; Wong, T Z; Sabbagh, M N; Sadowsky, C H; Fleisher, A S; Carpenter, A; Joshi, A D; Lu, M; Grundman, M; Mintun, M A; Skovronsky, D M; Pontecorvo, M J; Duara, Ranjan; Sabbagh, Marwan; Lawrence Ahern, Geoffrey; Holub, Richard F; Farmer, Mildred V; Safirstein, Beth Emmie; Alva, Gustavo; Longmire, Crystal F; Jewell, George; Johnson, Keith A; Korn, Ron; Reiman, Eric M; Wendt, Jeanette K; Wong, Dean; Doraiswamy, P Murali; Coleman, R Edward; Devous, Michael; Jennings, Danna; Weiner, Michael W; Murphy, Cynthia A; Kovnat, Karel D; Williamson, Jeff D; Sadowsky, Carl H (Nature Publishing Group, 2014)
      This study was designed to evaluate whether subjects with amyloid beta (Aβ) pathology, detected using florbetapir positron emission tomorgraphy (PET), demonstrated greater cognitive decline than subjects without Aβ pathology. ...

    • Neuronal Dysfunction and Disconnection of Cortical Hubs in Non-Demented Subjects with Elevated Amyloid Burden 

      Drzezga, Alexander; Sreenivasan, Aishwarya; Talukdar, Tanveer; Sullivan, Caroline; Sepulcre, Jorge; Putcha, Deepti; Becker, John Alex; van Dijk, Koene R A; Greve, Douglas N.; Johnson, Keith Alan; Sperling, Reisa Anne; Schultz, Aaron (Oxford University Press, 2011)
      Disruption of functional connectivity between brain regions may represent an early functional consequence of b-amyloid pathology prior to clinical Alzheimer’s disease. We aimed to investigate if non-demented older individuals ...

    • The SORL1 Gene and Convergent Neural Risk for Alzheimer's Disease Across the Human Lifespan 

      Felsky, Daniel; Szeszko, Philip; Yu, Lei; Honer, William G; De Jager, Philip L; Schneider, Julie A; Malhotra, Anil K; Lencz, Todd; Ikuta, Toshikazu; Pipitone, Jon; Chakravarty, M Mallar; Lobaugh, Nancy J; Mulsant, Benoit H; Pollock, Bruce G; Kennedy, James L; Bennett, David A; Voineskos, Aristotle N (2013)
      Prior to intervention trials in individuals genetically at-risk for late-onset Alzheimer's disease, critical first steps are identifying where (neuroanatomic effects), when (timepoint in the lifespan) and how (gene expression ...