Now showing items 1-8 of 8

    • Are Survey-based Estimates of the Burden of Drug Resistant TB Too Low? Insight from a Simulation Study 

      Cohen, Ted; Colijn, Caroline; Finklea, Bryson; Wright, Abigail; Zignol, Matteo; Pym, Alexander; Kretzschmar, Mirjam; Murray, Megan Blanche (Public Library of Science, 2008)
      Background: The emergence of tuberculosis resistant to multiple first- and second-line antibiotics poses challenges to a global control strategy that relies on standard drug treatment regimens. Highly drug-resistant strains ...
    • Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update 

      Bennett, Diane E.; Camacho, Ricardo J.; Otelea, Dan; Fleury, Hervé; Kiuchi, Mark; Heneine, Walid; Kantor, Rami; Jordan, Michael R.; Schapiro, Jonathan M.; Vandamme, Anne-Mieke; Sandstrom, Paul; van de Vijver, David; Rhee, Soo-Yon; Liu, Tommy F.; Pillay, Deenan; Shafer, Robert W.; Kuritzkes, Daniel Robert; Boucher, Charles Allen (Public Library of Science, 2009)
      Programs that monitor local, national, and regional levels of transmitted HIV-1 drug resistance inform treatment guidelines and provide feedback on the success of HIV-1 treatment and prevention programs. To accurately ...
    • Identification of Antifungal Compounds Active against Candida albicans Using an Improved High-Throughput Caenorhabditis elegans Assay 

      Okoli, Ikechukwu; Tempakakis, Emmanouil; Holson, Edward; Wagner, Florence; Conery, Annie L.; Larkins-Ford, Jonah; Stern, Andy; Coleman, Jeffrey James; An, W. Frank; Wu, Gang; Ausubel, Frederick M.; Mylonakis, Eleftherios (Public Library of Science, 2009)
      Candida albicans, the most common human pathogenic fungus, can establish a persistent lethal infection in the intestine of the microscopic nematode Caenorhabditis elegans. The C. elegans–C. albicans infection model was ...
    • Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen 

      Arnoldo, Anthony; Curak, Jasna; Kittanakom, Saranya; Chevelev, Igor; Sahebol-Amri, Mehdi; Koscik, Becky; Ljuma, Lana; Roy, Peter J.; Bedalov, Antonio; Giaever, Guri; Nislow, Corey; Merrill, Rod A.; Stagljar, Igor; Snyder, Michael; Lee, Vincent; Lory, Stephen (Public Library of Science, 2008)
      Pseudomonas aeruginosa is an opportunistic human pathogen that is a key factor in the mortality of cystic fibrosis patients, and infection represents an increased threat for human health worldwide. Because resistance of ...
    • The Impact of Different Antibiotic Regimens on the Emergence of Antimicrobial-Resistant Bacteria 

      D'Agata, Erika Maria Concetta; Dupont-Rouzeyrol, Myrielle; Magal, Pierre; Olivier, Damien; Ruan, Shigui (Public Library of Science, 2008)
      Backgroud: The emergence and ongoing spread of antimicrobial-resistant bacteria is a major public health threat. Infections caused by antimicrobial-resistant bacteria are associated with substantially higher rates of ...
    • Management of Extensively Drug-Resistant Tuberculosis in Peru: Cure Is Possible 

      Bonilla, Cesar A.; Crossa, Aldo; Jave, Hector O.; Jamanca, Ronal B.; Herrera, Cesar; Asencios, Luis; Mendoza, Alberto; Zignol, Matteo; Jaramillo, Ernesto; Mitnick, Carole Diane; Bayona, Jaime (Public Library of Science, 2008)
      Aim: To describe the incidence of extensive drug-resistant tuberculosis (XDR-TB) reported in the Peruvian National multidrug-resistant tuberculosis (MDR-TB) registry over a period of more than ten years and present the ...
    • Mobile Antibiotic Resistance Encoding Elements Promote Their Own Diversity 

      Garriss, Geneviève; Burrus, Vincent; Rosenberg, Susan M.; Waldor, Matthew K (Public Library of Science, 2009)
      Integrating conjugative elements (ICEs) are a class of bacterial mobile genetic elements that disseminate via conjugation and then integrate into the host cell genome. The SXT/R391 family of ICEs consists of more than 30 ...
    • Treatment-Mediated Alterations in HIV Fitness Preserve CD4+ T Cell Counts but Have Minimal Effects on Viral Load 

      Vaidya, Naveen K.; Rong, Libin; Marconi, Vincent C.; Kuritzkes, Daniel Robert; Deeks, Steven G.; Perelson, Alan S. (Public Library of Science, 2010)
      For most HIV-infected patients, antiretroviral therapy controls viral replication. However, in some patients drug resistance can cause therapy to fail. Nonetheless, continued therapy with a failing regimen can preserve or ...