Browsing HMS Scholarly Articles by Keyword "beta cells"

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    • Diabetic Microvascular Complications: Possible Targets for Improved Macrovascular Outcomes 

      D'Elia, John Anthony; Bayliss, George; Roshan, Bijan; Maski, Manish; Gleason, Ray Edward; Weinrauch, Larry Allan (Dove Medical Press, 2010)
      The results of recent outcome trials challenge hypotheses that tight control of both glycohemoglobin and blood pressure diminishes macrovascular events and survival among type 2 diabetic patients. Relevant questions exist ...

    • Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway 

      Blum, Barak; Roose, Adam N; Barrandon, Ornella; Maehr, René; Arvanites, Anthony C; Davidow, Lance S; Davis, Jeffrey C; Peterson, Quinn P; Rubin, Lee L; Melton, Douglas A (eLife Sciences Publications, Ltd, 2014)
      Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes (T2D) lower blood glucose levels but ...