Browsing HMS Scholarly Articles by Keyword "brain development"

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    • Generation of Mice with a Conditional Foxp2 Null Allele 

      French, Catherine A; Groszer, Matthias; Preece, Christopher; Coupe, Anne-Marie; Rajewsky, Klaus; Fisher, Simon E (Wiley-Blackwell, 2007)
      Disruptions of the human FOXP2 gene cause problems with articulation of complex speech sounds, accompanied by impairment in many aspects of language ability. The FOXP2/Foxp2 transcription factor is highly similar in humans ...

    • Multiple knockout mouse models reveal lincRNAs are required for life and brain development 

      Sauvageau, Martin; Goff, Loyal A; Lodato, Simona; Bonev, Boyan; Groff, Abigail F; Gerhardinger, Chiara; Sanchez-Gomez, Diana B; Hacisuleyman, Ezgi; Li, Eric; Spence, Matthew; Liapis, Stephen C; Mallard, William; Morse, Michael; Swerdel, Mavis R; D’Ecclessis, Michael F; Moore, Jennifer C; Lai, Venus; Gong, Guochun; Yancopoulos, George D; Frendewey, David; Kellis, Manolis; Hart, Ronald P; Valenzuela, David M; Arlotta, Paola; Rinn, John L (eLife Sciences Publications, Ltd, 2013)
      Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs ...

    • Variation in neural development as a result of exposure to institutionalization early in childhood 

      Sheridan, Margaret A.; Fox, N. A.; Zeanah, C. H.; Mclaughlin, K; Nelson, Charles A. (Proceedings of the National Academy of Sciences, 2012)
      We used structural MRI and EEG to examine brain structure and function in typically developing children in Romania (n = 20), children exposed to institutional rearing (n = 29), and children previously exposed to institutional ...