Browsing HMS Scholarly Articles by Keyword "cancer"
Now showing items 1-20 of 72
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Aberrant regulation of FBW7 in cancer
(Impact Journals LLC, 2014)FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc. In ... -
Advancing Cancer Systems Biology: Introducing the Center for the Development of a Virtual Tumor, CViT
(Libertas Academica, 2007)Integrative cancer biology research relies on a variety of data-driven computational modeling and simulation methods and techniques geared towards gaining new insights into the complexity of biological processes that are ... -
Analysis of AKT and ERK1/2 protein kinases in extracellular vesicles isolated from blood of patients with cancer
(Co-Action Publishing, 2014)Background: Extracellular vesicles (EVs) are small nanometre-sized vesicles that are circulating in blood. They are released by multiple cells, including tumour cells. We hypothesized that circulating EVs contain protein ... -
Arginine dependence of tumor cells: targeting a chink in cancer’s armor
(Springer Nature, 2016)Arginine, one among the twenty most common natural amino acids, plays a pivotal role in cellular physiology as it is being involved in numerous cellular metabolic and signaling pathways. Dependence on arginine is diverse ... -
BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles
(Nature Publishing Group, 2013)Development of biofluid-based molecular diagnostic tests for cancer is an important step towards tumor characterization and real-time monitoring in a minimally invasive fashion. Extracellular vesicles (EVs) are released ... -
Cancer in first-degree relatives of people with celiac disease
(Wolters Kluwer Health, 2016)Abstract Background: Celiac disease (CD) has been linked to cancer, especially lymphoproliferative malignancy (LPM). Earlier research has shown that first-degree relatives (FDRs) to individuals with CD are at increased ... -
Cell Death Pathways in Photodynamic Therapy of Cancer
(Molecular Diversity Preservation International (MDPI), 2011)Photodynamic therapy (PDT) is an emerging cancer therapy that uses the combination of non-toxic dyes or photosensitizers (PS) and harmless visible light to produce reactive oxygen species and destroy tumors. The PS can be ... -
Cesium-associated hypokalemia successfully treated with amiloride
(Oxford University Press, 2015)Self-treatment of cancer with cesium chloride, despite proven lack of efficacy, continues to produce serious adverse effects. Among these is hypokalemia predisposing to life-threatening arrhythmia. The mechanism of ... -
Cytochrome P450-Derived Eicosanoids: The Neglected Pathway in Cancer
(Springer US, 2010)Endogenously produced lipid autacoids are locally acting small molecule mediators that play a central role in the regulation of inflammation and tissue homeostasis. A well-studied group of autacoids are the products of ... -
Diagnostic technologies for circulating tumour cells and exosomes
(Portland Press Ltd., 2016)Circulating tumour cells (CTCs) and exosomes are promising circulating biomarkers. They exist in easily accessible blood and carry large diversity of molecular information. As such, they can be easily and repeatedly obtained ... -
Diet, nutrition, and avoidable cancer
(US Department of Health and Human Services, 1995)In a 1981 review, Doll and Peto estimated that approximately 35% of cancer deaths in the United States were potentially avoidable by the modification of diet but that this percentage might be as low as 10% or as high as ... -
Discovering cancer immunotherapy targets in vivo
(Landes Bioscience, 2014)A key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery ... -
Discovering Causal Signaling Pathways Through Gene-Expression Patterns
(Oxford University Press, 2010)High-throughput gene-expression studies result in lists of differentially expressed genes. Most current meta-analyses of these gene lists include searching for significant membership of the translated proteins in various ... -
DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction
(Impact Journals LLC, 2012)The Mdm2 oncoprotein promotes p53 ubiquitination and destruction. Yet, exact molecular mechanisms of Mdm2 destruction itself, under DNA damaging conditions, remain unclear. Recently, we identified SCFβ-TRCP as a novel E3 ... -
DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy
(WILEY-VCH Verlag, 2012)Targeted Cancer Therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (PEG=polyethylene glycol). This ... -
Drug Resistance in Cancer: An Overview
(MDPI, 2014)Cancers have the ability to develop resistance to traditional therapies, and the increasing prevalence of these drug resistant cancers necessitates further research and treatment development. This paper outlines the current ... -
The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation
(Frontiers Media S.A., 2014)The control of chromosome segregation relies on the spindle assembly checkpoint (SAC), a complex regulatory system that ensures the high fidelity of chromosome segregation in higher organisms by delaying the onset of ... -
Estimates of benefits and harms of prophylactic use of aspirin in the general population
(Oxford University Press, 2014)Background: Accumulating evidence supports an effect of aspirin in reducing overall cancer incidence and mortality in the general population. We reviewed current data and assessed the benefits and harms of prophylactic use ... -
Evaluation of Cancer Metabolomics Using ex vivo High Resolution Magic Angle Spinning (HRMAS) Magnetic Resonance Spectroscopy (MRS)
(MDPI, 2016)According to World Health Organization (WHO) estimates, cancer is responsible for more deaths than all coronary heart disease or stroke worldwide, serving as a major public health threat around the world. High resolution ... -
The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions
(Frontiers Media S.A., 2015)Natural killer T (NKT) cells comprise a family of specialized T cells that recognize lipid antigens presented by CD1d. Based on their T cell receptor (TCR) usage and antigen specificities, CD1d-restricted NKT cells have ...