Browsing HMS Scholarly Articles by Keyword "cardiovascular physiology and circulation"
Now showing items 1-4 of 4
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Chaotic Signatures of Heart Rate Variability and Its Power Spectrum in Health, Aging and Heart Failure
(Public Library of Science, 2009)A paradox regarding the classic power spectral analysis of heart rate variability (HRV) is whether the characteristic high- (HF) and low-frequency (LF) spectral peaks represent stochastic or chaotic phenomena. Resolution ... -
Hypoxia Activates a Ca-Permeable Cation Conductance Sensitive to Carbon Monoxide and to GsMTx-4 in Human and Mouse Sickle Erythrocytes
(Public Library of Science, 2010)Background: Deoxygenation of sickle erythrocytes activates a cation permeability of unknown molecular identity (Psickle), leading to elevated intracellular [Ca2+] ([Ca2+]i) and subsequent activation of KCa 3.1. The resulting ... -
Luminal Flow Amplifies Stent-based Drug Deposition in Arterial Bifurcations
(Public Library of Science, 2009)Background: Treatment of arterial bifurcation lesions using drug-eluting stents (DES) is now common clinical practice and yet the mechanisms governing drug distribution in these complex morphologies are incompletely ... -
Primary Role of Functional Ischemia, Quantitative Evidence for the Two-Hit Mechanism, and Phosphodiesterase-5 Inhibitor Therapy in Mouse Muscular Dystrophy
(Public Library of Science, 2007)Background: Duchenne Muscular Dystrophy (DMD) is characterized by increased muscle damage and an abnormal blood flow after muscle contraction: the state of functional ischemia. Until now, however, the cause-effect relationship ...