Browsing HMS Scholarly Articles by Keyword "cartilage"
Now showing items 1-6 of 6
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Biological Knee Reconstruction With Concomitant Autologous Chondrocyte Implantation and Meniscal Allograft Transplantation: Mid- to Long-term Outcomes
(SAGE Publications, 2016)Background: Treating articular cartilage defects and meniscal deficiency is challenging. Although some short- to mid-term follow-up studies report good clinical outcomes after concurrent autologous chondrocyte implantation ... -
Biomechanical Considerations in the Pathogenesis of Osteoarthritis of the Knee
(Springer-Verlag, 2011)Osteoarthritis is the most common joint disease and a major cause of disability. The knee is the large joint most affected. While chronological age is the single most important risk factor of osteoarthritis, the pathogenesis ... -
Clinical Outcome and Return to Competition after Microfracture in the Athlete’s Knee: An Evidence-Based Systematic Review
(SAGE Publications, 2010)Microfracture is frequently used for articular cartilage repair in athletes. This study aimed to define the strength and weaknesses of this minimally invasive cartilage repair technique in the athletic population in an ... -
Distribution of Basement Membrane Molecules, Laminin and Collagen Type IV, in Normal and Degenerated Cartilage Tissues
(SAGE Publications, 2014)Objective: The objective of the present study was to investigate the presence and distribution of 2 basement membrane (BM) molecules, laminin and collagen type IV, in healthy and degenerative cartilage tissues. Design: ... -
SIRT1 Regulates Differentiation of Mesenchymal Stem Cells by Deacetylating β-Catenin
(WILEY-VCH Verlag, 2013)Mesenchymal stem cells (MSCs) are multi-potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines with aging. We investigated whether the sirtuin SIRT1 had a ... -
TAK1 is an Essential Regulator of BMP Signalling in Cartilage
(Nature Publishing Group, 2009)TGFβ activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions ranging from innate and adaptive immune system activation to vascular development and apoptosis. To analyse the in vivo function of ...