Browsing HMS Scholarly Articles by Keyword "cell death"
Now showing items 1-10 of 10
-
Cell Death Pathways in Photodynamic Therapy of Cancer
(Molecular Diversity Preservation International (MDPI), 2011)Photodynamic therapy (PDT) is an emerging cancer therapy that uses the combination of non-toxic dyes or photosensitizers (PS) and harmless visible light to produce reactive oxygen species and destroy tumors. The PS can be ... -
Deactivation of Akt by a Small Molecule Inhibitor Targeting Pleckstrin Homology Domain and Facilitating Akt Ubiquitination
(Proceedings of the National Academy of Sciences, 2011)The phosphatidylinositol-3,4,5-triphosphate (PIP3) binding function of pleckstrin homology (PH) domain is essential for the activation of oncogenic Akt/PKB kinase. Following the PIP3-mediated activation at the membrane, ... -
Expression of the human papillomavirus type 16 E7 oncoprotein induces an autophagy-related process and sensitizes normal human keratinocytes to cell death in response to growth factor deprivation
(Elsevier BV, 2009)Expression of oncogenes, such as the human papillomavirus type 16 (HPV16) E7 oncoprotein, promotes aberrant cell proliferation. In the absence of concurrent mitogenic stimuli, this triggers a cell-intrinsic defense mechanism, ... -
How to survive a nerve-wracking journey
(eLife Sciences Publications, Ltd, 2013)When the axons that carry signals to muscles are growing, they rely on help from Frizzled3—a protein that is known to perform a number of other important functions in cells—to reach their final destination. -
Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling
(Impact Journals LLC, 2015)One challenge in biology is signal transduction monitoring in a physiological context. Intravital imaging techniques are revolutionizing our understanding of tumor and host cell behaviors in the tumor environment. However, ... -
A Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells
(Public Library of Science, 2011)MicroRNAs (miRNAs) post-transcriptionally regulate the expression of thousands of distinct mRNAs. While some regulatory interactions help to maintain basal cellular functions, others are likely relevant in more specific ... -
Microtubule Dynamics Regulates Akt Signaling via Dynactin p150
(Elsevier BV, 2014)Following activation at the plasma membrane, Akt is subsequently deactivated in the cytoplasm. Although activation and deactivation of Akt must sometimes be separated in order to elicit and control cellular responses, the ... -
A Novel Small-Molecule Tumor Necrosis Factor \(\alpha\) Inhibitor Attenuates Inflammation in a Hepatitis Mouse Model
(American Society for Biochemistry & Molecular Biology (ASBMB), 2014)Over-expression of tumor necrosis factor α (TNFα) is a hallmark of many inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease and septic shock and hepatitis, making it a potential therapeutic ... -
Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival
(Ivyspring International Publisher, 2012)Several signaling cascades are involved in cell death, with a significant amount of crosstalk between them. Despite the complexity of these cascades several key pro-survival and pro-death players have been identified. These ... -
Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy
(MDPI, 2015)Ionizing radiation (IR), such as X-rays and gamma (γ)-rays, mediates various forms of cancer cell death such as apoptosis, necrosis, autophagy, mitotic catastrophe, and senescence. Among them, apoptosis and mitotic catastrophe ...