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Statistical analysis of fiber bundles using multi-tensor tractography: application to first-episode schizophrenia
(Elsevier BV, 2011)
This work proposes a new method to detect abnormalities in fiber bundles of first-episode (FE) schizophrenia patients. Existing methods have either examined a particular region of interest (ROI) or used voxel based morphometry ...
White matter tract abnormalities between rostral middle frontal gyrus, inferior frontal gyrus and striatum in first-episode schizophrenia
(Elsevier BV, 2013)
Background—Previous studies have shown that frontostriatal networks, especially those involving dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) mediate cognitive functions some of which ...
Molecular Profiles of Parvalbumin-Immunoreactive Neurons in the Superior Temporal Cortex in Schizophrenia
(Informa Healthcare, 2014)
Dysregulation of pyramidal cell network function by the soma- and axon-targeting inhibitory neurons that contain the calcium-binding protein parvalbumin (PV) represents a core pathophysiological feature of schizophrenia. ...
Clinical high risk and first episode schizophrenia: Auditory event-related potentials
(Elsevier BV, 2015)
The clinical high risk (CHR) period is a phase denoting a risk for overt psychosis during which subacute symptoms often appear, and cognitive functions may deteriorate. To compare biological indices during this phase with ...
Molecular Profiles of Pyramidal Neurons in the Superior Temporal Cortex in Schizophrenia
(Informa Healthcare, 2014)
Disrupted synchronized oscillatory firing of pyramidal neuronal networks in the cerebral cortex in the gamma frequency band (i.e., 30–100 Hz) mediates many of the cognitive deficits and symptoms of schizophrenia. In fact, ...
Frequency and pattern of childhood symptom onset reported by first episode schizophrenia and clinical high risk youth
(Elsevier BV, 2014)
Background—Psychosis prevention and early intervention efforts in schizophrenia have focused increasingly on sub-threshold psychotic symptoms in adolescents and young adults. Although many youth report symptom onset prior ...
Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset
(Society for Neuroscience, 2012)
Diffusion MRI has been successful in identifying the existence of white matter abnormalities in schizophrenia in vivo. However, the role of these abnormalities in the etiology of schizophrenia is not well understood. ...
Extensive white matter abnormalities in patients with first-episode schizophrenia: A diffusion tensor imaging (DTI) study
(Elsevier BV, 2013)
Background—Previous voxelwise Diffusion Tensor Imaging (DTI) investigations of white matter in first-episode schizophrenia (FESZ) have been limited to the analysis of Fractional Anisotropy (FA) and mean diffusivity (MD), ...
Biomarkers for Identifying First-Episode Schizophrenia Patients Using Diffusion Weighted Imaging
(Springer Science + Business Media, 2010)
Recent advances in diffusion weighted MR imaging (dMRI) has made it a tool of choice for investigating white matter abnormalities of the brain and central nervous system. In this work, we design a system that detects ...