Now showing items 1-10 of 115
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis
(The Rockefeller University Press, 2012)
IL-1b signaling augments continued splenic monocyte supply during acute inflammation.
A Guanidine-rich Regulatory Oligodeoxynucleotide Improves Type-2 Diabetes in Obese Mice by Blocking T-cell Differentiation
(WILEY-VCH Verlag, 2012)
T lymphocytes exhibit pro-inflammatory or anti-inflammatory activities in obesity and diabetes, depending on their subtypes. Guanidine-rich immunosuppressive oligodeoxynucleotides (ODNs) effectively control Th1/Th2-cell ...
Local proliferation dominates lesional macrophage accumulation in atherosclerosis
During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall1,2. The observation that circulating monocytes give rise to lesional macrophages3–9 has ...
AGE-BSA decreases ABCG1 expression and reduces macrophage cholesterol efflux to HDL
(Elsevier BV, 2007)
Background Previous reports have suggested that advanced glycation end products (AGE) participate in the pathogenesis of diabetic macroangiopathy. However, current understanding of the mechanisms by which AGE may accelerate ...
Systemic Thrombin Inhibition by Hirulog Does Not Alter Medial Smooth Muscle Cell Proliferation and Inflammatory Activation after Vascular Injury in the Rabbit
(Springer Science + Business Media, 1999)
Summary. The study evaluated the role of thrombin in activation of vascular smooth muscle cells early after vascular injury. The direct thrombin inhibitor Hirulog (10 mg/kg SQ tid) or vehicle was administered to rabbits ...
Adiponectin inhibits macrophage tissue factor, a key trigger of thrombosis in disrupted atherosclerotic plaques
(Elsevier BV, 2013)
Objective Adiponectin (APN) is an adipocytokine with anti-atherogenic and anti-inflammatory properties. Hypoadiponectinemia may associate with increased risk for coronary artery disease (CAD) and acute coronary syndrome ...
Stromelysin-1 (MMP-3) expression driven by a macrophage-specific promoter results in reduced viability in transgenic mice
(Elsevier BV, 2000)
Macrophage expression of matrix degrading metalloproteinases (MMPs) in human atheroma has been found to occur in rupture-prone areas of plaques. To investigate the effect of metalloproteinase activity on plaque stability, ...
Wild-type but not interferon-γ-deficient T cells induce graft arterial disease in the absence of B cells
(Oxford University Press (OUP), 2004)
Interferon-γ (IFN-γ), a cytokine produced primarily by T cells and by activated macrophages, plays a central role in the pathogenesis of graft arterial disease (GAD). This study investigated whether T cells can induce GAD ...
Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)
(Elsevier BV, 2011)
Background Inflammation contributes to all phases of the atherothrombotic process, and patients with elevated inflammatory biomarkers such as high-sensitivity C-reactive protein (hsCRP) have increased vascular risk. Yet, ...
Induction of Endothelial-Leukocyte Interaction by Interferon-\(\gamma\) Requires Coactivation of Nuclear Factor-\(\kappa\)B
(American Heart Association, 2001)
To determine whether nuclear factor (NF)-\(\kappa\) B is necessary to confer endothelial cell responsiveness to interferon (INF)-\(\gamma\) in terms of vascular cell adhesion molecule (VCAM)-1 expression and leukocyte ...