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Topical Interleukin 1 Receptor Antagonist for Treatment of Dry Eye Disease
(American Medical Association (AMA), 2013)
Importance
The immunopathogenic mechanisms of dry eye disease (DED), one of the most common ophthalmic conditions, is incompletely understood. Data from this prospective, double-masked, randomized trial demonstrate that ...
Unilateral Herpes Zoster Ophthalmicus Results in Bilateral Corneal Nerve Alteration
(Elsevier BV, 2013)
Purpose
Herpes zoster ophthalmicus (HZO), thought to be a unilateral disease, results in loss of corneal sensation, leading to neurotrophic keratopathy. This study aimed to analyze bilateral corneal nerve changes in ...
In Vivo Confocal Microscopic Changes of the Corneal Epithelium and Stroma in Patients With Herpes Zoster Ophthalmicus
(Elsevier BV, 2015)
Purpose
To analyze the density and morphology of corneal epithelial cells and keratocytes by in vivo confocal microscopy (IVCM) in patients with herpes zoster ophthalmicus (HZO) as associated with corneal innervation. ...
Efficacy of Topical Blockade of Interleukin-1 in Experimental Dry Eye Disease
(Elsevier BV, 2012)
PURPOSE
To evaluate the therapeutic efficacy of topical IL-1Ra in the treatment of Dry Eye Disease (DED).
DESIGN
Laboratory Investigation.
METHODS
DED was induced in C57BL/6 female mice through exposure to a ...
Cellular Changes of the Corneal Epithelium and Stroma in Herpes Simplex Keratitis
(Elsevier BV, 2012)
Purpose
To analyze the morphology of corneal epithelial cells and keratocytes by in vivo confocal microscopy (IVCM) in patients with herpes simplex keratitis (HSK) as associated with corneal innervation.
Design
...
Topical Bevacizumab in the Treatment of Corneal Neovascularization
(American Medical Association (AMA), 2009)
Objectives
To study the safety and efficacy of topical bevacizumab in the treatment of corneal neovascularization (NV).
Design
In a prospective, open-label, non-comparative study, 10 eyes from 10 patients with ...
Effects of Topical and Subconjunctival Bevacizumab in High-Risk Corneal Transplant Survival
(Association for Research in Vision and Ophthalmology (ARVO), 2010)
Purpose.
To investigate whether corneal graft survival could be improved by topical or subconjunctival bevacizumab in a murine model of vascularized high-risk corneal transplantation.
Methods.
Before corneal ...
Corneal Sensation and Subbasal Nerve Alterations in Patients with Herpes Simplex Keratitis
(Elsevier BV, 2010)
Purpose
To study and correlate corneal sensation in patients with herpes simplex keratitis (HSK) with density and morphology of subbasal corneal nerves by in vivo confocal microscopy (IVCM).
Design
Prospective, ...
Effect of Topical Azithromycin on Corneal Innate Immune Responses
(Association for Research in Vision and Ophthalmology (ARVO), 2011)
Purpose.
To determine the effect of azithromycin (AZM) in a murine model of corneal inflammation.
Methods.
The effect of topical AZM was studied in murine corneal inflammation. Corneal inflammation was induced by ...
Corneal Neovascularization and the Utility of Topical VEGF Inhibition: Ranibizumab (Lucentis) Vs Bevacizumab (Avastin)
(Elsevier BV, 2012)
Corneal avascularity is necessary for the preservation of optimal vision. The cornea maintains a dynamic balance between pro- and antiangiogenic factors that allows it to remain avascular under normal homeostatic conditions; ...