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Chronic Dry Eye Disease is Principally Mediated by Effector Memory Th17 Cells
(2013)
Recent experimental and clinical data suggest that there is a link between dry eye disease (DED) and T cell-mediated immunity. However, whether these immune responses are a consequence or cause of ocular surface inflammation ...
Involvement of Corneal Lymphangiogenesis in a Mouse Model of Allergic Eye Disease
(Association for Research in Vision and Ophthalmology (ARVO), 2015)
Purpose.
The contribution of lymphangiogenesis (LA) to allergy has received considerable attention and therapeutic inhibition of this process via targeting VEGF has been considered. Likewise, certain inflammatory settings ...
Characterization of Langerin-Expressing Dendritic Cell Subsets in the Normal Cornea
(Association for Research in Vision and Ophthalmology (ARVO), 2011)
Purpose.
In addition to Langerhans cells (LCs), other dendritic cells (CD11c+) have recently been shown to express Langerin (c-type lectin). In skin, (non-LC) Langerin+ dendritic cells initiate adaptive immunity. However, ...
Gamma-Irradiation Reduces the Allogenicity of Donor Corneas
(Association for Research in Vision and Ophthalmology (ARVO), 2012)
Purpose.
To evaluate the utility and allogenicity of gamma-irradiated corneal allografts.
Methods.
Corneal buttons were harvested from C57BL/6 mice and decellularized with gamma irradiation. Cell viability was ...
Effect of Desiccating Environmental Stress Versus Systemic Muscarinic AChR Blockade on Dry Eye Immunopathogenesis
(Association for Research in Vision and Ophthalmology (ARVO), 2013)
Purpose.
A majority of experimental data on dry eye disease (DED) immunopathogenesis have been derived from a murine model of DED that combines desiccating environmental stress with systemic muscarinic acetylcholine ...
Dependence of Corneal Stem/Progenitor Cells on Ocular Surface Innervation
(Association for Research in Vision and Ophthalmology (ARVO), 2012)
Purpose.
Neurotrophic keratopathy (NK) is a corneal degeneration associated with corneal nerve dysfunction. It can cause corneal epithelial defects, stromal thinning, and perforation. However, it is not clear if and to ...
CCL-21 Conditioned Regulatory T Cells Induce Allotolerance through Enhanced Homing to Lymphoid Tissue
(The American Association of Immunologists, 2013)
Regulatory T cells (Tregs) are instrumental in the induction and maintenance of tolerance, including in transplantation. Tregs induce allotolerance by interacting with antigen-presenting cells (APC) and T cells, interactions ...
Depletion of Passenger Leukocytes from Corneal Grafts: An Effective Means of Promoting Transplant Survival?
(Association for Research in Vision and Ophthalmology (ARVO), 2009)
Purpose
To develop and compare effective strategies for depleting graft-derived passenger leukocytes which include antigen-presenting cells from corneal buttons, and to assess the effectiveness of this strategy in ...
Anti-angiogenesis Effect of the Novel Anti-inflammatory and Pro-resolving Lipid Mediators
(Association for Research in Vision and Ophthalmology (ARVO), 2009)
Purpose.Resolvins and lipoxins are lipid mediators generated from essential polyunsaturated fatty acids that are the first dual anti-inflammatory and pro-resolving signals identified in the resolution phase of inflammation. ...
Effects of Topical and Subconjunctival Bevacizumab in High-Risk Corneal Transplant Survival
(Association for Research in Vision and Ophthalmology (ARVO), 2010)
Purpose.
To investigate whether corneal graft survival could be improved by topical or subconjunctival bevacizumab in a murine model of vascularized high-risk corneal transplantation.
Methods.
Before corneal ...