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Expression of the chemokine decoy receptor D6 mediates dendritic cell function and promotes corneal allograft rejection
(Molecular Vision, 2013)
Purpose To identify the role of chemokine receptor 6 (D6) expression by dendritic cells (DCs) and its role in corneal transplant immunity. Methods: Flow cytometry analysis was used to assess the expression level of the D6 ...
Safety and Efficacy of the Multitargeted Receptor Kinase Inhibitor Pazopanib in the Treatment of Corneal Neovascularization
(Association for Research in Vision and Ophthalmology (ARVO), 2013)
Purpose.
To evaluate the safety and efficacy of topical pazopanib in the treatment of corneal neovascularization (CNV).
Methods.
Twenty eyes of 20 patients with stable CNV were enrolled in a prospective, open ...
Nerves and Neovessels Inhibit Each Other in the Cornea
(Association for Research in Vision and Ophthalmology (ARVO), 2013)
Purpose.
To evaluate the regulatory cross-talk of the vascular and neural networks in the cornea.
Methods.
b-FGF micropellets (80 ng) were implanted in the temporal side of the cornea of healthy C57Bl/6 mice. On ...
Effect of Desiccating Environmental Stress Versus Systemic Muscarinic AChR Blockade on Dry Eye Immunopathogenesis
(Association for Research in Vision and Ophthalmology (ARVO), 2013)
Purpose.
A majority of experimental data on dry eye disease (DED) immunopathogenesis have been derived from a murine model of DED that combines desiccating environmental stress with systemic muscarinic acetylcholine ...
The CCR6/CCL20 Axis Mediates Th17 Cell Migration to the Ocular Surface in Dry Eye Disease
(Association for Research in Vision and Ophthalmology (ARVO), 2013)
Purpose.
Th17 cells are believed to be the primary effector cells in the pathogenesis of dry eye disease (DED). However, the mechanisms by which Th17 cells migrate from the lymphoid tissues to the ocular surface are ...
PDE4 Inhibition Suppresses IL-17–Associated Immunity in Dry Eye Disease
(Association for Research in Vision and Ophthalmology (ARVO), 2012)
Purpose.
To determine the effect of phosphodiesterase type-4 (PDE4) inhibition on IL-17–associated immunity in experimental dry eye disease (DED).
Methods.
Murine DED was induced, after which a PDE4 inhibitor ...
Vascular Endothelial Growth Factor-C Promotes Alloimmunity by Amplifying Antigen-Presenting Cell Maturation and Lymphangiogenesis
(Association for Research in Vision and Ophthalmology (ARVO), 2012)
Purpose.
To investigate the role of anti–vascular endothelial growth factor (VEGF)-C therapy in corneal graft survival and concomitant suppression of hem- and lymph-angiogenesis.
Methods.
Corneal suture model in ...
b-FGF Induces Corneal Blood and Lymphatic Vessel Growth in a Spatially Distinct Pattern
(Ovid Technologies (Wolters Kluwer Health), 2012)
Purpose
To study the spatial variances in ligand expression and angiogenic effect in response to the inflammatory response induced by b-FGF.
Methods
b-FGF micropellets (80ng) were implanted in the temporal side ...
Effects of Topical and Subconjunctival Bevacizumab in High-Risk Corneal Transplant Survival
(Association for Research in Vision and Ophthalmology (ARVO), 2010)
Purpose.
To investigate whether corneal graft survival could be improved by topical or subconjunctival bevacizumab in a murine model of vascularized high-risk corneal transplantation.
Methods.
Before corneal ...
Effect of Topical Azithromycin on Corneal Innate Immune Responses
(Association for Research in Vision and Ophthalmology (ARVO), 2011)
Purpose.
To determine the effect of azithromycin (AZM) in a murine model of corneal inflammation.
Methods.
The effect of topical AZM was studied in murine corneal inflammation. Corneal inflammation was induced by ...