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An Integrated Strategy for Analyzing the Unique Developmental Programs of Different Myoblast Subtypes
(Public Library of Science, 2006)
An important but largely unmet challenge in understanding the mechanisms that govern the formation of specific organs is to decipher the complex and dynamic genetic programs exhibited by the diversity of cell types within ...
Targeted and Genome-Scale Methylomics Reveals Gene Body Signatures in Human Cell Lines
(Nature Publishing Group, 2009)
Cytosine methylation, an epigenetic modification of DNA, is a target of growing interest for developing high throughput profiling technologies. Here we introduce two new, complementary techniques for cytosine methylation ...
Public Access to Genome-Wide Data: Five Views on Balancing Research with Privacy and Protection
(Public Library of Science, 2009)
Introductory paragraph: Just over twelve months ago, PLoS Genetics published a paper [1] demonstrating that, given genome-wide genotype data from an individual, it is, in principle, possible to ascertain whether that ...
Large-scale identification of genetic design strategies using local search
(Nature Publishing Group, 2009)
In the past decade, computational methods have been shown to be well suited to unraveling the complex web of metabolic reactions in biological systems. Methods based on flux–balance analysis (FBA) and bi-level optimization ...
The Personal Genome Project
(Nature Publishing Group, 2005)
Expression Dynamics of a Cellular Metabolic Network
(Nature Publishing Group, 2005)
Toward the goal of understanding system properties of biological networks, we investigate the global and local regulation of gene expression in the Saccharomyces cerevisiae metabolic network. Our results demonstrate ...
Model-Driven Analysis of Experimentally Determined Growth Phenotypes for 465 Yeast Gene Deletion Mutants Under 16 Different Conditions
(BioMed Central, 2008)
Background: Understanding the response of complex biochemical networks to genetic perturbations and environmental variability is a fundamental challenge in biology. Integration of high-throughput experimental assays and ...
Automated Modelling of Signal Transduction Networks
(BioMed Central, 2002)
Background: Intracellular signal transduction is achieved by networks of proteins and small molecules that transmit information from the cell surface to the nucleus, where they ultimately effect transcriptional changes. ...
Hippocrates Revisited? Old Ideals and New Realities
(Springer Verlag, 2008)
Individual genomics has arrived, personal decisions to make use of it are a new reality. What are the implications for the patient–physician relationship? In this article we address three factors that call the traditional ...
Rapid Prototyping of 3D DNA-Origami Shapes with caDNAno
(Oxford University Press, 2009)
DNA nanotechnology exploits the programmable specificity afforded by base-pairing to produce self-assembling macromolecular objects of custom shape. For building megadalton-scale DNA nanostructures, a long ‘scaffold’ strand ...