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Plasma Pentraxin 3 Levels Do Not Predict Coronary Events but Reflect Metabolic Disorders in Patients with Coronary Artery Disease in the CARE Trial
(Public Library of Science, 2014)
Chronic inflammation closely associates with obesity, metabolic syndrome, diabetes mellitus, and atherosclerosis. Evidence indicates that the immunomodulator pentraxin 3 (PTX3) may serve as a biomarker of these cardiometabolic ...
Local proliferation dominates lesional macrophage accumulation in atherosclerosis
(2013)
During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall1,2. The observation that circulating monocytes give rise to lesional macrophages3–9 has ...
A Guanidine-rich Regulatory Oligodeoxynucleotide Improves Type-2 Diabetes in Obese Mice by Blocking T-cell Differentiation
(WILEY-VCH Verlag, 2012)
T lymphocytes exhibit pro-inflammatory or anti-inflammatory activities in obesity and diabetes, depending on their subtypes. Guanidine-rich immunosuppressive oligodeoxynucleotides (ODNs) effectively control Th1/Th2-cell ...
Inflammatory Biomarkers, Death, and Recurrent Nonfatal Coronary Events after an Acute Coronary Syndrome in the MIRACL Study
(Blackwell Publishing, 2013)
Background: In acute coronary syndromes, C‐reactive protein (CRP) strongly relates to subsequent death, but surprisingly not to recurrent myocardial infarction. Other biomarkers may reflect different processes related to ...
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis
(The Rockefeller University Press, 2012)
IL-1b signaling augments continued splenic monocyte supply during acute inflammation.
Myocardial Infarction Accelerates Atherosclerosis
(Nature Publishing Group, 2012)
During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaque in the arterial wall and cause its rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a ...
Murine “Model” Monotheism: an Iconoclast at the Altar of Mouse
(Ovid Technologies (Wolters Kluwer Health), 2015)
Many use mice for contemporary cardiovascular research, as we should, given the power of the genetic and other tools developed to permit rigorous mechanistic experimentation in this species. We must remain mindful, ...
Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease
(Elsevier BV, 2016)
Physicians have traditionally viewed ischemic heart disease in a cardiocentric manner: plaques grow in arteries until they block blood flow, causing acute coronary and other ischemic syndromes. Recent research provides new ...
Requiem for the ‘vulnerable plaque’
(Oxford University Press (OUP), 2015)
Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter
(Nature Publishing Group, 2015)
Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms1, 2. Interruption of IL18 action reduces atherosclerosis in mice3, 4. Here, we show that absence of the IL18 receptor (IL18r) does not ...