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Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines
(American Society for Clinical Investigation, 1995)
Scavenger receptor (ScR)-mediated uptake of modified lipoproteins may contribute to the transformation of smooth muscle cells into lipid-laden foam cells during atherogenesis. This study examined the in vivo expression of ...
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells
(American Society for Clinical Investigation, 1998)
Formation of the atherosclerotic intima must involve altered metabolism of the elastin-rich arterial extracellular matrix. Proteases potentially involved in these processes remain unclear. This study examined the expression ...
Hyperlipidemia and Atherosclerotic Lesion Development in LDL Receptor Deficient Mice Fed Defined Semipurified Diets With and Without Cholate
(Ovid Technologies (Wolters Kluwer Health), 1999)
Past studies of atherosclerosis in mice have used chow-based diets supplemented with cholesterol, lipid, and sodium cholate to overcome species resistance to lesion formation. Similar diets have been routinely used in ...
Diversity of T-cell antigen receptor V beta gene utilization in advanced human atheroma
(Ovid Technologies (Wolters Kluwer Health), 1994)
Human atheromata contain T lymphocytes, but knowledge of the function and receptor specificity of these cells is limited. Immunohistochemical studies have established that T cells in advanced human carotid plaques express ...
Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
(American Society for Clinical Investigation, 1994)
Dysregulated extracellular matrix (ECM) metabolism may contribute to vascular remodeling during the development and complication of human atherosclerotic lesions. We investigated the expression of matrix metalloproteinases ...
An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium
(Ovid Technologies (Wolters Kluwer Health), 1993)
Accumulation of monocyte-derived foam cells in focal areas of the arterial intima is a key step in early atherogenesis. We investigated the expression of vascular cell adhesion molecule-1 (VCAM-1), a mononuclear leukocyte ...
Matrix Metalloproteinase-13 Predominates Over Matrix Metalloproteinase-8 as the Functional Interstitial Collagenase in Mouse Atheromata
(Ovid Technologies (Wolters Kluwer Health), 2014)
Objective—Substantial evidence implicates interstitial collagenases of the matrix metalloproteinase (MMP) family in plaque rupture and fatal thrombosis. Understanding the compensatory mechanisms that may influence the ...
Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6
(American Society for Clinical Investigation, 1990)
The cells that make up blood vessel walls appear to participate actively in local immune and inflammatory responses, as well as in certain vascular diseases. We tested here whether smooth muscle cells (SMC) can produce the ...
HMG CoA Reductase Inhibitors Reduce Plasminogen Activator Inhibitor-1 Expression by Human Vascular Smooth Muscle and Endothelial Cells
(American Heart Association, 2000)
The clinical benefit of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) may derive from a qualitative, functional change in atherosclerotic lesions in addition to their lipid-lowering properties. We ...
Atherogenesis in Mice Does Not Require CD40 Ligand from Bone Marrow-Derived Cells
(American Heart Association, 2005)
Objective. Recent research suggests a central role for CD40 ligand (CD40L) in atherogenesis. However, the relevant cellular source of this proinflammatory cytokine remains unknown. To test the hypothesis that CD40L expressed ...