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Does FXIII Deficiency Impair Wound Healing after Myocardial Infarction?
(Public Library of Science, 2006)
Inadequate healing of myocardial infarction may contribute to local expansion of the infarct, frequently leading to chamber dilation, heart failure, or myocardial rupture. Experimental evidence in mouse models suggests ...
Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging
(MyJove Corporation, 2009)
Optical projection tomography is a three-dimensional imaging technique that has been recently introduced as an imaging tool primarily in developmental biology and gene expression studies. The technique renders biological ...
Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma
(Public Library of Science, 2008)
Background: Pancreatic ductal adenocarcinoma (PDAC) carries an extremely poor prognosis, typically presenting with metastasis at the time of diagnosis and exhibiting profound resistance to existing therapies. The development ...
PepBank - A Database of Peptides Based on Sequence Text Mining and Public Peptide Data Sources
(BioMed Central, 2007)
Background: Peptides are important molecules with diverse biological functions and biomedical uses. To date, there does not exist a single, searchable archive for peptide sequences or associated biological data. Rather, ...
Enhancing Navigation in Biomedical Databases by Community Voting and Database-Driven Text Classification
(BioMed Central, 2009)
Background: The breadth of biological databases and their information content continues to increase exponentially. Unfortunately, our ability to query such sources is still often suboptimal. Here, we introduce and apply ...
Arthritis Imaging Using a Near-Infrared Fluorescence Folate-Targeted Probe
(BioMed Central, 2005)
A recently developed near-infrared fluorescence-labeled folate probe (NIR2-folate) was tested for in vivo imaging of arthritis using a lipopolysaccharide intra-articular injection model and a KRN transgenic mice serum ...
Nanoparticle-Target Interactions Parallel Antibody-Protein Interactions
(American Chemical Society, 2009)
Magnetic particles can act as magnetic relaxation switches (MRSVs) when they bind to target analytes, and switch between their dispersed and aggregated states resulting in changes in the spin-spin relaxation time (T(2)) ...
Monocyte Subset Dynamics in Human Atherosclerosis Can Be Profiled with Magnetic Nano-Sensors
(Public Library of Science, 2009)
Monocytes are circulating macrophage and dendritic cell precursors that populate healthy and diseased tissue. In humans, monocytes consist of at least two subsets whose proportions in the blood fluctuate in response to ...
BRAF Activation Initiates but Does Not Maintain Invasive Prostate Adenocarcinoma
(Public Library of Science, 2008)
Prostate cancer is the second leading cause of cancer-related deaths in men. Activation of MAP kinase signaling pathway has been implicated in advanced and androgen-independent prostate cancers, although formal genetic ...
A Near-Infrared Cell Tracker Reagent for Multiscopic In Vivo Imaging and Quantification of Leukocyte Immune Responses
(Public Library of Science, 2007)
The complexity of the tumor microenvironment necessitates that cell behavior is studied in a broad, multi-scale context. Although tomographic and microscopy-based far and near infrared fluorescence (NIRF, >650 nm) imaging ...