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Salvinorin A and Derivatives: Protection from Metabolism Does Not Prolong Short-Term, Whole-Brain Residence
(Elsevier BV, 2009)
Salvinorin A (SA) is a potent kappa opioid agonist with a brief duration of action. Consistent with this, our previous positron emission tomography (PET) studies of carbon-11 labeled SA showed that brain levels decrease ...
One-Pot, Direct Incorporation of [11 C]CO 2 into Carbamates
(Wiley-Blackwell, 2009)
Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of 11CO2 with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of 11C-labeled carbamates at 75 °C ...
Metabolic Changes in the Rodent Brain after Acute Administration of Salvinorin A
(Springer Nature, 2009)
Purpose: Salvinorin A (SA) is a potent and highly selective kappa-opioid receptor (KOR) agonist with rapid kinetics and commensurate behavioral effects; however, brain regions associated with these effects have not been ...
[11C]PR04.MZ, a Promising DAT Ligand for Low Concentration Imaging: Synthesis, Efficient 11C-O-Methylation and Initial Small Animal PET Studies
(Elsevier BV, 2009)
PR04.MZ was designed as a highly selective dopamine transporter inhibitor, derived from natural cocaine. Its binding profile indicates that [11C]PR04.MZ may be suited as a PET radioligand for the non-invasive exploration ...
Effects of Modafinil on Dopamine and Dopamine Transporters in the Male Human Brain
(American Medical Association (AMA), 2009)
Context: Modafinil, a wake-promoting drug used to treat narcolepsy, is increasingly being used as a cognitive enhancer. Although initially launched as distinct from stimulants that increase extracellular dopamine by targeting ...
Reinvestigation of the Synthesis and Evaluation of [N-methyl-11C]vorozole, a Radiotracer Targeting Cytochrome P450 Aromatase
(Elsevier BV, 2009)
Introduction: We reinvestigated the synthesis of [N-methyl-11C]vorozole, a radiotracer for aromatase, and discovered the presence of an N-methyl isomer which was not removed in the original purification method. Herein we ...