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Increased Gray Matter Diffusion Anisotropy in Patients with Persistent Post-Concussive Symptoms following Mild Traumatic Brain Injury
(Public Library of Science, 2013)
A significant percentage of individuals diagnosed with mild traumatic brain injury (mTBI) experience persistent post-concussive symptoms (PPCS). Little is known about the pathology of these symptoms and there is often no ...
Estimation of Extracellular Volume from Regularized Multi-shell Diffusion MRI
(Springer Science + Business Media, 2012)
Diffusion MRI measures micron scale displacement of water molecules, providing unique insight into microstructural tissue architecture. However, current practical image resolution is in the millimeter scale, and thus ...
Gray matter alterations in early aging: A diffusion magnetic resonance imaging study
(Wiley-Blackwell, 2013)
Many studies have observed altered neurofunctional and structural organization in the aging brain. These observations from functional neuroimaging studies show a shift in brain activity from the posterior to the anterior ...
Hockey Concussion Education Project, Part 2. Microstructural white matter alterations in acutely concussed ice hockey players: a longitudinal free-water MRI study
(Journal of Neurosurgery Publishing Group (JNSPG), 2014)
Object—Concussion is a common injury in ice hockey and a health problem for the general population. Traumatic axonal injury has been associated with concussions (also referred to as mild traumatic brain injuries), yet the ...
Hockey Concussion Education Project, Part 3. White matter microstructure in ice hockey players with a history of concussion: a diffusion tensor imaging study
(Journal of Neurosurgery Publishing Group (JNSPG), 2014)
Object—The aim of this study was to examine the brain’s white matter microstructure using magnetic resonance diffusion tensor imaging (DTI) in ice hockey players with a history of clinically symptomatic concussion compared ...
Widespread white matter degeneration preceding the onset of dementia
(Elsevier BV, 2015)
Background—Brain atrophy in subjects with mild cognitive impairment (MCI) introduces partial volume effects, limiting the sensitivity of diffusion tensor imaging to white matter microstructural degeneration. Appropriate ...
Comparing free water imaging and magnetization transfer measurements in schizophrenia
(Elsevier BV, 2015)
Diffusion weighted imaging (DWI) has been extensively used to study the microarchitecture of white matter in schizophrenia. However, popular DWI-derived measures such as fractional anisotropy (FA) may be sensitive to many ...
The Sport Concussion Education Project. A brief report on an educational initiative: from concept to curriculum
(Journal of Neurosurgery Publishing Group (JNSPG), 2014)
Current research on concussion is primarily focused on injury identification and treatment. Prevention initiatives are, however, important for reducing the incidence of brain injury. This report examines the development ...
Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression
(Elsevier, 2015)
Diffusion tensor imaging (DTI) holds promise for developing our understanding of white-matter pathology in major depressive disorder (MDD). Variable findings in DTI-based investigations of MDD, however, have thwarted ...
Abnormal white matter microstructure and increased extracellular free-water in the cingulum bundle associated with delusions in chronic schizophrenia
(Elsevier, 2016)
Background: There is growing evidence to suggest that delusions associated with schizophrenia arise from altered structural brain connectivity. The present study investigated whether structural changes in three major ...