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Now showing items 111-118 of 118
Inflammation and plaque vulnerability
(Wiley-Blackwell, 2015)
Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs at sites of blood flow disturbance. The disease usually remains silent until a breakdown of integrity at the arterial surface triggers ...
Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3
(Elsevier BV, 2015)
Abdominal Aortic Aneurysm (AAA) is a major cause of mortality and morbidity in men over 65 years of age. Male apolipoprotein E knockout (ApoE−/−) mice infused with angiotensin II (AngII) develop AAA. Although AngII stimulates ...
Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth
(Nature Publishing Group, 2015)
Resident macrophages densely populate the normal arterial wall, yet their origins and the mechanisms that sustain them are poorly understood. Here we use gene-expression profiling to show that arterial macrophages constitute ...
A Rock and a Hard Place
(Ovid Technologies (Wolters Kluwer Health), 2017)
Redundancy of IL-1 Isoform Signaling and Its Implications for Arterial Remodeling
(Public Library of Science, 2016)
Aims Mice deficient in IL-1 receptor 1 (hence unresponsive to both IL-1 isoforms α and β) have impaired expansive arterial remodeling due to diminished expression of matrix-degrading enzymes, especially MMP-3. Emergence ...
Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in MiceNovelty and Significance
(Ovid Technologies (Wolters Kluwer Health), 2017)
IRF3 and type I interferons fuel a fatal response to myocardial infarction
(Springer Nature, 2017)
Interferon regulatory factor 3 (IRF3) and type I interferons (IFNs) protect against infections and cancer, but excessive IRF3 activation and type I IFN production cause autoinflammatory conditions such as Aicardi–Goutières ...
The changing landscape of atherosclerosis
(Springer Science and Business Media LLC, 2021-04-21)
Emerging evidence has spurred considerable evolution of concepts of atherosclerosis and called into question many cherished notions. Atherosclerosis risk no longer concentrates in Western countries, but now reaches globally ...