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If You Don’t Find It Often, You Often Don’t Find It: Why Some Cancers Are Missed in Breast Cancer Screening
(Public Library of Science, 2013)
Mammography is an important tool in the early detection of breast cancer. However, the perceptual task is difficult and a significant proportion of cancers are missed. Visual search experiments show that miss (false negative) ...
Statistical Analysis of Molecular Signal Recording
(Public Library of Science, 2013)
A molecular device that records time-varying signals would enable new approaches in neuroscience. We have recently proposed such a device, termed a “molecular ticker tape”, in which an engineered DNA polymerase (DNAP) ...
Multi-Scale Glycemic Variability: A Link to Gray Matter Atrophy and Cognitive Decline in Type 2 Diabetes
(Public Library of Science, 2014)
Objective: Type 2 diabetes mellitus (DM) accelerates brain aging and cognitive decline. Complex interactions between hyperglycemia, glycemic variability and brain aging remain unresolved. This study investigated the ...
Rules from Words: A Dynamic Neural Basis for a Lawful Linguistic Process
(Public Library of Science, 2014)
Listeners show a reliable bias towards interpreting speech sounds in a way that conforms to linguistic restrictions (phonotactic constraints) on the permissible patterning of speech sounds in a language. This perceptual ...
Untreated Sleep-Disordered Breathing: Links to Aging-Related Decline in Sleep-Dependent Memory Consolidation
(Public Library of Science, 2014)
Background: Increasing age is associated with a decline in cognition and motor skills, while at the same time exacerbating one's risk of developing obstructive sleep apnea (OSA). OSA-related cognitive deficits are highly ...
Cigarette Smoke Toxins Deposited on Surfaces: Implications for Human Health
(Public Library of Science, 2014)
Cigarette smoking remains a significant health threat for smokers and nonsmokers alike. Secondhand smoke (SHS) is intrinsically more toxic than directly inhaled smoke. Recently, a new threat has been discovered – Thirdhand ...
Tissue Specific Roles for the Ribosome Biogenesis Factor Wdr43 in Zebrafish Development
(Public Library of Science, 2014)
During vertebrate craniofacial development, neural crest cells (NCCs) contribute to most of the craniofacial pharyngeal skeleton. Defects in NCC specification, migration and differentiation resulting in malformations in ...
A Sexually Conditioned Switch of Chemosensory Behavior in C. elegans
(Public Library of Science, 2013)
In sexually reproducing animals, mating is essential for transmitting genetic information to the next generation and therefore animals have evolved mechanisms for optimizing the chance of successful mate location. In the ...
GPR56 Functions Together with α3β1 Integrin in Regulating Cerebral Cortical Development
(Public Library of Science, 2013)
Loss of function mutations in GPR56, which encodes a G protein-coupled receptor, cause a specific human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Studies from BFPP postmortem brain tissue ...
Visual Attention Measures Predict Pedestrian Detection in Central Field Loss: A Pilot Study
(Public Library of Science, 2014)
Purpose The ability of visually impaired people to deploy attention effectively to maximize use of their residual vision in dynamic situations is fundamental to safe mobility. We conducted a pilot study to evaluate whether ...