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Now showing items 31-40 of 131
Comparison of Two Questionnaires for Dry Eye Symptom Assessment
(Elsevier BV, 2015)
Purpose
The aim of this study was to compare patient reported symptoms of dry eye disease (DED) as assessed by the Ocular Surface Disease Index (OSDI©), a 12-item symptom frequency-based questionnaire, and the Symptom ...
Effect of Desiccating Environmental Stress Versus Systemic Muscarinic AChR Blockade on Dry Eye Immunopathogenesis
(Association for Research in Vision and Ophthalmology (ARVO), 2013)
Purpose.
A majority of experimental data on dry eye disease (DED) immunopathogenesis have been derived from a murine model of DED that combines desiccating environmental stress with systemic muscarinic acetylcholine ...
The CCR6/CCL20 Axis Mediates Th17 Cell Migration to the Ocular Surface in Dry Eye Disease
(Association for Research in Vision and Ophthalmology (ARVO), 2013)
Purpose.
Th17 cells are believed to be the primary effector cells in the pathogenesis of dry eye disease (DED). However, the mechanisms by which Th17 cells migrate from the lymphoid tissues to the ocular surface are ...
A Novel Mouse Model for Neurotrophic Keratopathy: Trigeminal Nerve Stereotactic Electrolysis through the Brain
(Association for Research in Vision and Ophthalmology (ARVO), 2011)
Purpose.
To develop a mouse model of neurotrophic keratopathy by approaching the trigeminal nerve through the brain and to evaluate changes in corneal cell apoptosis and proliferation.
Methods.
Six- to 8-week-old ...
Therapeutic Efficacy of Topical Epigallocatechin Gallate in Murine Dry Eye
(Ovid Technologies (Wolters Kluwer Health), 2011)
Objective
To study the efficacy of topical epigallocatechin gallate (EGCG) for treatment of dry eye disease (DED).
Methods
Female 7–8 week old C57BL/6 mice were housed in the controlled environment chamber to ...
The Resolvin D1 Analogue Controls Maturation of Dendritic Cells and Suppresses Alloimmunity in Corneal Transplantation
(Association for Research in Vision and Ophthalmology (ARVO), 2014)
Purpose.
To analyze the effect of a resolvin D1 (RvD1) analogue (RvD1a) on dendritic cell maturation, T-cell sensitization, and allograft rejection in corneal allotransplantation.
Methods.
The receptor expression ...
Consensus Statement on the Immunohistochemical Detection of Ocular Lymphatic Vessels
(Association for Research in Vision and Ophthalmology (ARVO), 2014)
There is currently considerable controversy about existence and classification of “lymphatic vessels” in the eye. Some of the confusion is certainly caused by inappropriate use (or nonuse) of the correct immunohistochemical ...
PDE4 Inhibition Suppresses IL-17–Associated Immunity in Dry Eye Disease
(Association for Research in Vision and Ophthalmology (ARVO), 2012)
Purpose.
To determine the effect of phosphodiesterase type-4 (PDE4) inhibition on IL-17–associated immunity in experimental dry eye disease (DED).
Methods.
Murine DED was induced, after which a PDE4 inhibitor ...
Efficacy of Topical Blockade of Interleukin-1 in Experimental Dry Eye Disease
(Elsevier BV, 2012)
PURPOSE
To evaluate the therapeutic efficacy of topical IL-1Ra in the treatment of Dry Eye Disease (DED).
DESIGN
Laboratory Investigation.
METHODS
DED was induced in C57BL/6 female mice through exposure to a ...
Dependence of Corneal Stem/Progenitor Cells on Ocular Surface Innervation
(Association for Research in Vision and Ophthalmology (ARVO), 2012)
Purpose.
Neurotrophic keratopathy (NK) is a corneal degeneration associated with corneal nerve dysfunction. It can cause corneal epithelial defects, stromal thinning, and perforation. However, it is not clear if and to ...