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Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
(American Association for the Advancement of Science (AAAS), 2015)
Human mutations that truncate the massive sarcomere protein titin [TTN-truncating variants (TTNtvs)] are the most common genetic cause for dilated cardiomyopathy (DCM), a major cause of heart failure and premature death. ...
Spatial information in large-scale neural recordings
(Frontiers Media S.A., 2015)
To record from a given neuron, a recording technology must be able to separate the activity of that neuron from the activity of its neighbors. Here, we develop a Fisher information based framework to determine the conditions ...
Complete Genome Sequence of Methanobacterium Thermoautotrophicum deltaH: Functional Analysis and Comparative Genomics
(American Society for Microbiology, 1997)
The complete 1,751,377-bp sequence of the genome of the thermophilic archaeon Methanobacterium thermoautotrophicum deltaH has been determined by a whole-genome shotgun sequencing approach. A total of 1,855 open reading ...
Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization
(American Society for Microbiology, 1997-10)
We have developed a new system of chromosomal mutagenesis in order to study the functions of uncharacterized open reading frames (ORFs) in wild-type Escherichia coli. Because of the operon structure of this organism, ...
Multiplex Sequencing of 1.5 Mb of theMycobacterium Leprae Genome
(Cold Spring Harbor Laboratory, 1997-08)
The nucleotide sequence of 1.5 Mb of genomic DNA from Mycobacterium leprae was determined using computer-assisted multiplex sequencing technology. This brings the 2.8-Mb M. leprae genome sequence to approximately 66% ...
Genomic Studies with Escherichia coli MelR Protein: Applications of Chromatin Immunoprecipitation and Microarrays
(American Society for Microbiology, 2004)
Escherichia coli MelR protein is a transcription activator that is essential for melibiose-dependent expression of the melAB genes. We have used chromatin immunoprecipitation to study the binding of MelR and RNA polymerase ...
Systematic Management and Analysis of Yeast Gene Expression Data
(Cold Spring Harbor Laboratory, 2000-04)
We report steps toward the systematic management, standardization, and analysis of functional genomics data. We developed the ExpressDB database for yeast RNA expression data and loaded it with approximately 17.5 million ...
Multiplex Sequencing of 1.5 Mb of the <i>Mycobacterium leprae</i> Genome
(Cold Spring Harbor Laboratory, 1997-08-01)
The nucleotide sequence of 1.5 Mb of genomic DNA from Mycobacterium leprae was determined using computer-assisted multiplex sequencing technology. This brings the 2.8-Mb M. leprae genome sequence to ∼66% completion. The ...
Conservation of DNA Regulatory Motifs and Discovery of New Motifs in Microbial Genomes
(Cold Spring Harbor Laboratory, 2000-06-01)
Regulatory motifs can be found by local multiple alignment of upstream regions from coregulated sets of genes, or regulons. We searched for regulatory motifs using the program AlignACE together with a set of filters that ...
Computation-Based Discovery of Related Transcriptional Regulatory Modules and Motifs Using an Experimentally Validated Combinatorial Model
(Cold Spring Harbor Laboratory, 2002-07)
Gene expression is regulated by transcription factors that interact with cis-regulatory elements. Predicting these elements from sequence data has proven difficult. We describe here a successful computational search for ...