Browsing Harvard T.H. Chan School of Public Health by Title

Now showing items 2882-2901 of 6618

    • The H1N1 pandemic: media frames, stigmatization and coping 

      McCauley, Michael; Minsky, Sara; Viswanath, Kasisomayajula (BioMed Central, 2013)
      Background: Throughout history, people have soothed their fear of disease outbreaks by searching for someone to blame. Such was the case with the April 2009 H1N1 flu outbreak. Mexicans and other Latinos living in the US ...

    • H1N1 vaccination and adults with underlying health conditions in the US 

      Goldstein, Edward; Lipsitch, Marc (Public Library of Science (PLoS), 2009)
      65% of fatalities from pH1N1 infections in a large US case series occur in adults with underlying health conditions other than pregnancy, but it appears that only relatively few high-risk adults will get vaccinated during ...

    • Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men12 

      Cassidy, Aedín; Bertoia, Monica; Chiuve, Stephanie; Flint, Alan; Forman, John; Rimm, Eric B (American Society for Nutrition, 2016)
      Background: Although increased fruit intake reduces cardiovascular disease (CVD) risk, which fruits are most beneficial and what key constituents are responsible are unclear. Habitual intakes of flavonoids, specifically ...

    • Habitual intake of dietary flavonoids and risk of Parkinson disease 

      Gao, X.; Cassidy, A.; Schwarzschild, M. A.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Ascherio, A. (2012)
      Objective: To prospectively examine whether higher intakes of total flavonoids and their subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, and polymers) were associated with a lower risk of developing ...

    • Habitual intake of flavonoid subclasses and incident hypertension in adults 

      Cassidy, Aedín; O'Reilly, Éilis J.; Kay, Colin; Sampson, Laura; Franz, Mary; Forman, J. P.; Curhan, Gary; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 (Oxford University Press, 2011)
      Background: Dietary flavonoids have beneficial effects on blood pressure in intervention settings, but there is limited information on habitual intake and risk of hypertension in population-based studies. Objective: We ...

    • Habitual intake of flavonoid subclasses and risk of colorectal cancer in 2 large prospective cohorts12 

      Nimptsch, Katharina; Zhang, Xuehong; Cassidy, Aedín; Song, Mingyang; O’Reilly, Éilis J; Lin, Jennifer H; Pischon, Tobias; Rimm, Eric B; Willett, Walter C; Fuchs, Charles S; Ogino, Shuji; Chan, Andrew T; Giovannucci, Edward L; Wu, Kana (American Society for Nutrition, 2016)
      Background: Flavonoids inhibit the growth of colon cancer cells in vitro. In a secondary analysis of a randomized controlled trial, the Polyp Prevention Trial, a higher intake of one subclass, flavonols, was statistically ...

    • Haematological Safety of Perinatal Zidovudine in Pregnant HIV-1–Infected Women in Thailand: Secondary Analysis of a Randomized Trial 

      Briand, Nelly; Lallemant, Marc Jean; Jourdain, Gonzague Joseph Albert; Techapalokul, Somnuek; Tunthanathip, Preecha; Suphanich, Surachet; Chanpoo, Truengta; Traisathit, Patrinee; McIntosh, Kenneth; Coeur, Sophie Le (Public Library of Science, 2007)
      Objectives: To respond to the primary safety objective of the Perinatal HIV Prevention Trial 1 (PHPT-1) by studying the evolution of haematological parameters according to zidovudine exposure duration in HIV-1−infected ...

    • Hair Manganese and Hyperactive Behaviors: Pilot Study of School-Age Children Exposed through Tap Water 

      Bouchard, Maryse; Laforest, François; Vandelac, Louise; Bellinger, David C.; Mergler, Donna (National Institute of Environmental Health Sciences, 2006)
      Background: Neurotoxic effects are known to occur with inhalation of manganese particulates, but very few data are available on exposure to Mn in water. We undertook a pilot study in a community in Québec (Canada) where ...

    • Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation 

      Tomasetti, Cristian; Vogelstein, Bert; Parmigiani, Giovanni (National Academy of Sciences, 2013)
      Although it has been hypothesized that some of the somatic mutations found in tumors may occur before tumor initiation, there is little experimental or conceptual data on this topic. To gain insights into this fundamental ...

    • Hallux valgus and plantar pressure loading: the Framingham foot study 

      Galica, Andrew M; Hagedorn, Thomas J; Dufour, Alyssa B; Riskowski, Jody L; Hillstrom, Howard J; Casey, Virginia A; Hannan, Marian T (BioMed Central, 2013)
      Background: Hallux valgus (HV), a common structural foot deformity, can cause foot pain and lead to limited mobility. The purpose of this study was to evaluate differences in plantar pressure and force during gait by HV ...

    • Halo effect of a weight-loss trial on spouses: the DIRECT-Spouse study 

      Golan, Rachel; Schwarzfuchs, Dan; Stampfer, Meir; Shai, Iris (Cambridge University Press, 2010)
      Objective: We examined the halo effect of a 2-year weight-loss diet trial, the Dietary Intervention Randomized Controlled Trial (DIRECT), on the weight and nutritional patterns of participants' spouses. Design: DIRECT ...

    • Handling random errors and biases in methods used for short-term dietary assessment 

      Rossato, Sinara L; Fuchs, Sandra C (Faculdade de Saúde Pública da Universidade de São Paulo, 2014)
      Epidemiological studies have shown the effect of diet on the incidence of chronic diseases; however, proper planning, designing, and statistical modeling are necessary to obtain precise and accurate food consumption data. ...

    • Handling the data management needs of high-throughput sequencing data: SpeedGene, a compression algorithm for the efficient storage of genetic data 

      Qiao, Dandi; Yip, Wai-Ki; Lange, Christoph (BioMed Central, 2012)
      Background: As Next-Generation Sequencing data becomes available, existing hardware environments do not provide sufficient storage space and computational power to store and process the data due to their enormous size. ...

    • Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring 

      Lao, Taotao; Glass, Kimberly; Qiu, Weiliang; Polverino, Francesca; Gupta, Kushagra; Morrow, Jarrett; Mancini, John Dominic; Vuong, Linh; Perrella, Mark A; Hersh, Craig P; Owen, Caroline A; Quackenbush, John; Yuan, Guo-Cheng; Silverman, Edwin K; Zhou, Xiaobo (BioMed Central, 2015)
      Background: The HHIP gene, encoding Hedgehog interacting protein, has been implicated in chronic obstructive pulmonary disease (COPD) by genome-wide association studies (GWAS), and our subsequent studies identified a ...

    • Haplotype Block Partitioning and Tag SNP Selection Using Genotype Data and Their Applications to Association Studies 

      Zhang, Kui; Qin, Zhaohui S.; Liu, Jun; Chen, Ting; Waterman, Michael S.; Sun, Fengzhu (Cold Spring Harbor Laboratory Press, 2004)
      Recent studies have revealed that linkage disequilibrium (LD) patterns vary across the human genome with some regions of high LD interspersed by regions of low LD. A small fraction of SNPs (tag SNPs) is sufficient to capture ...

    • Haplotype Information and Linkage Disequilibrium Mapping for Single Nucleotide Polymorphisms 

      Lu, Xin; Niu, Tianhua; Liu, Jun (Cold Spring Harbor Laboratory Press, 2003)
      Single nucleotide polymorphisms in the human genome have become an increasingly popular topic in that their analyses promise to be a key step toward personalized medicine. We investigate two related questions, how much the ...

    • Haptoglobin Genotype Is a Consistent Marker of Coronary Heart Disease Risk Among Individuals with Elevated Glycosylated Hemoglobin 

      Cahill, Leah E.; Levy, Andrew P.; Chiuve, Stephanie E.; Jensen, Majken K.; Wang, Hong; Shara, Nawar M.; Blum, Shany; Howard, Barbara V.; Pai, Jennifer K.; Mukamal, Kenneth J.; Rexrode, Kathryn M.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 (Elsevier, 2013)
      Objectives This study sought to investigate into the biologically plausible interaction between the common haptoglobin (Hp) polymorphism rs#72294371 and glycosylated hemoglobin (HbA(1c)) on risk of coronary heart disease ...

    • Harnessing Poverty Alleviation to Reduce the Stigma of HIV in Sub-Saharan Africa 

      Tsai, Alexander C.; Bangsberg, David R.; Weiser, Sheri D. (Public Library of Science, 2013)
      Alexander Tsai and colleagues highlight the complex relationship between poverty and HIV stigma in sub-Saharan Africa, and discuss possible ways to break the cycle. Please see later in the article for the Editors' Summary

    • Harnessing the diversity of small-scale actors is key to the future of aquatic food systems 

      Short, Rebecca E.; Gelcich, Stefan; Little, David C.; Micheli, Fiorenza; Allison, Edward H.; Basurto, Xavier; Belton, Ben; Brugere, Cecile; Bush, Simon R.; Cao, Ling; Crona, Beatrice; Cohen, Philippa J.; Defeo, Omar; Edwards, Peter; Ferguson, Caroline E.; Franz, Nicole; Golden, Christopher; Halpern, Benjamin S.; Hazen, Lucie; Hicks, Christina; Johnson, Derek; Kaminski, Alexander M.; Mangubhai, Sangeeta; Naylor, Rosamond L.; Reantaso, Melba; Sumaila, U. Rashid; Thilsted, Shakuntala H.; Tigchelaar, Michelle; Wabnitz, Colette C. C.; Zhang, Wenbo (Springer Science and Business Media LLC, 2021-09-15)

    • Harnessing the Medicaid Analytic eXtract (MAX) to Evaluate Medications in Pregnancy: Design Considerations 

      Palmsten, Kristin; Huybrechts, Krista F.; Mogun, Helen; Kowal, Mary K.; Williams, Paige L.; Michels, Karin B.; Setoguchi, Soko; Hernández-Díaz, Sonia (Public Library of Science, 2013)
      Background: In the absence of clinical trial data, large post-marketing observational studies are essential to evaluate the safety and effectiveness of medications during pregnancy. We identified a cohort of pregnancies ...