Browsing Harvard T.H. Chan School of Public Health by Title
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04. Experiential Integrative Approaches to Heart Health
(Global Advances in Health and Medicine, 2013)Focus Areas: Integrative Approaches to Care, Experiential Workshop This session will highlight two of the most important, yet frequently overlooked, determinants of heart health: mind-body interactions and nutrition. These ... -
A 19-year-old at 37 weeks gestation with an acute acetylsalicylic acid overdose
(Oxford University Press, 2011)Acute salicylate overdose in pregnancy is potentially fatal for both the mother and fetus and presents a unique challenge in intensive care management. While suggested thresholds exist for hemodialysis in adults with toxic ... -
2-Year BMI Changes of Children Referred for Multidisciplinary Weight Management
(Hindawi Publishing Corporation, 2014)Objective. To examine body mass index (BMI) changes among pediatric multidisciplinary weight management participants and nonparticipants. Design. In this retrospective database analysis, we used multivariable mixed effect ... -
The 2015 Bioinformatics Open Source Conference (BOSC 2015)
(Public Library of Science, 2016)The Bioinformatics Open Source Conference (BOSC) is organized by the Open Bioinformatics Foundation (OBF), a nonprofit group dedicated to promoting the practice and philosophy of open source software development and open ... -
24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex
(Public Library of Science, 2014)Circadian rhythms modulate the biology of many human tissues, including brain tissues, and are driven by a near 24-hour transcriptional feedback loop. These rhythms are paralleled by 24-hour rhythms of large portions of ... -
25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men : A Prospective Study
(American Medical Association, 2008)Background: Vitamin D deficiency may be involved in the development of atherosclerosis and coronary heart disease in humans.Methods: We assessed prospectively whether plasma 25-hydroxyvitamin D (25[OH]D) concentrations are ... -
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water.
(2002)There is limited information on the prevalence of the potent mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in U.S. water supplies. We measured MX concentrations and mutagenic activity in tap water samples ... -
3D Traction Forces in Cancer Cell Invasion
(Public Library of Science, 2012)Cell invasion through a dense three-dimensional (3D) matrix is believed to depend on the ability of cells to generate traction forces. To quantify the role of cell tractions during invasion in 3D, we present a technique ... -
50-year trends in US socioeconomic inequalities in health: US-born Black and White Americans, 1959–2008
(Oxford University Press (OUP), 2014-03-16)Background: Debates exist over whether health inequities are bound to rise as population health improves, due to health improving more quickly among the better off, with most analyses focused on mortality data. Methods: ... -
5α-reductase Inhibitors and Risk of High-grade or Lethal Prostate Cancer
(American Medical Association, 2014) -
87 Rare Variants Associated With Blood Pressure in Meta-Analysis of ∼1.32 Million Individuals
(Ovid Technologies (Wolters Kluwer Health), 2021-04)Genetic studies of blood pressure (BP) to date have mainly analysed common variants (minor allele frequency, MAF>0.05). In a meta-analysis of up to >1.3 million participants, we discovered 106 new BP-associated genomic ... -
A 25 Year Prospective Study of Plasma Adiponectin and Leptin Concentrations and Prostate Cancer Risk and Survival
(American Association for Clinical Chemistry, 2010)BACKGROUND: Adipocytokines may mediate the association between adiposity and lethal prostate cancer outcomes. Methods: In the Physicians' Health Study, we prospectively examined the association of prediagnostic plasma ... -
A case-control study of GST polymorphisms and arsenic related skin lesions
(BMC, 2007)Background: Polymorphisms in GSTT1, GSTM1 and GSTP1 impact detoxification of carcinogens by GSTs and have been reported to increase susceptibility to environmentally related health outcomes. Individual factors in arsenic ... -
A Cohort Study of Tumoral LINE-1 Hypomethylation and Prognosis in Colon Cancer
(Oxford University Press, 2008)Genome-wide DNA hypomethylation plays has an important role in genomic instability and colorectal carcinogenesis. However, the relationship between cellular DNA methylation level and patient outcome remains uncertain. Using ... -
A Common 8q24 Variant in Prostate and Breast Cancer from a Large Nested Case-Control Study
(American Association for Cancer Research, 2007)Two recent studies independently identified polymorphisms in the 8q24 region, including a single nucleotide polymorphism (rsl447295), strongly associated with prostate cancer risk. Here, we replicate the overall association ... -
A Comparison of Different Methods for Evaluating Diet, Physical Activity, and Long-Term Weight Gain in 3 Prospective Cohort Studies
(Oxford University Press, 2015)Background: The insidious pace of long-term weight gain (similar to 1 lb/y or 0.45 kg/y) makes it difficult to study in trials; long-term prospective cohorts provide crucial evidence on its key contributors. Most previous ... -
A Comparison of the Clinical and Cost-Effectiveness of 3 Intervention Strategies for AIDS Wasting
(Lippincott, Williams & Wilkins, 2005)Objective: To compare oxandrolone (OX) or strength training with nutrition alone (NA) for AIDS wasting.Subjects: Fifty patients with AIDS; 47 completing the study. Interventions: Randomization to (1) NA with placebo pills, ... -
A Cost-Effectiveness Analysis of Folic Acid Fortification Policy in the United States
(Cambridge University Press, 2009)Objective: To quantity the health and economic Outcome, associated with changes in folic acid consumption following the fortification of enriched grain products in the USA. Design: Cost-effectiveness analysis. Setting: ...