Now showing items 1-10 of 11
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum
(BioMed Central, 2009)
Background: The identification of genetic changes that confer drug resistance or other phenotypic changes in pathogens can help optimize treatment strategies, support the development of new therapeutic agents, and provide ...
Student Behavior during a School Closure Caused by Pandemic Influenza A/H1N1
(Public Library of Science, 2010)
Background: Many schools were temporarily closed in response to outbreaks of the recently emerged pandemic influenza A/H1N1 virus. The effectiveness of closing schools to reduce transmission depends largely on student/family ...
Use of Cumulative Incidence of Novel Influenza A/H1N1 in Foreign Travelers to Estimate Lower Bounds on Cumulative Incidence in Mexico
(Public Library of Science, 2009)
Background: An accurate estimate of the total number of cases and severity of illness of an emerging infectious disease is required both to define the burden of the epidemic and to determine the severity of disease. When ...
Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues
(American Chemical Society (ACS), 2011)
Passage of environmental chemicals across the placenta has important toxicological consequences, as well as for choosing samples for analysis and for interpreting the results. To obtain systematic data, we collected in ...
Thyroid Dysfunction as a Mediator of Organochlorine Neurotoxicity in Preschool Children
(Environmental Health Perspectives, 2011)
Background: Exposure to organochlorine compounds (OCs) can alter thyroid function in humans, and hypothyroidism during early life can adversely affect a child’s neurodevelopment. Objectives: In this study we aimed to assess ...
Marine Food Pollutants as a Risk Factor for Hypoinsulinemia and Type 2 Diabetes
(Ovid Technologies (Wolters Kluwer Health), 2011)
Background: Some persistent environmental chemicals are suspected of causing an increased risk of type 2 diabetes mellitus, a disease particularly common after the age of 70. This concern was examined in a cross-sectional ...
Physician communication styles in initial consultations for hematological cancer
(Elsevier BV, 2013)
Objective To characterize practices in subspecialist physicians’ communication styles, and their potential effects on shared decision-making, in second-opinion consultations. Methods Theme-oriented discourse ...
Tumor dormancy and surgery-driven interruption of dormancy in breast cancer: learning from failures
(Nature Publishing Group, 2007)
Primary tumor removal, usually considered intrinsically beneficial, can perturb metastatic homeostasis, and for some patients results in the acceleration of metastatic cancer. The continuous-growth model is required to ...
Dormancy and surgery-driven escape from dormancy help explain some clinical features of breast cancer
To explain bimodal relapse patterns observed in breast cancer data, we have proposed that metastatic breast cancer growth commonly includes periods of temporary dormancy at both the single cell phase and the avascular ...
Increasing ambient temperature reduces emotional well-being
(Elsevier BV, 2016)