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Direct Assessment of Cumulative Aryl Hydrocarbon Receptor Agonist Activity in Sera from Experimentally Exposed Mice and Environmentally Exposed Humans
(National Institute of Environmental Health Sciences, 2009)
Background: Aryl hydrocarbon receptor (AhR) ligands adversely affect many biological processes. However, assessment of the significance of human exposures is hampered by an incomplete understanding of how complex mixtures ...
Serum polychlorinated biphenyl and organochlorine insecticide concentrations in a Faroese birth cohort
(Elsevier BV, 2006)
A prospective birth cohort of 1022 participants was established in the Faroe Islands over a 21-month period during 1986–1987. We collected questionnaire data on potential persistent organic pollutant (POP) concentration ...
Spermatogenic capacity in fertile men with elevated exposure to polychlorinated biphenyls
(Elsevier BV, 2015)
Background
Endocrine disrupting industrial chemicals, such as polychlorinated biphenyls (PCBs), are suspected to adversely affect male reproductive functions.
Objectives
The Faroe Islands community exhibits an ...
Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population
(Springer Nature, 2005)
Objective
The purpose of the study was to study the distribution of poor and extensive metabolizers of CYP2C19 and CYP2D6 and to genotype for CYP2C8 and CYP2C9 among 312 randomly selected Faroese.
Methods and ...
Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls
(Springer Nature, 2006)
Objective
To investigate the CYP1A2 phenotype distribution in a population with an increased exposure to polychlorinated biphenyls (PCBs) that would likely induce an increased activity of this enzyme. Further, to ...