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Airway Obstruction in Asthma: Does the Response to a Deep Inspiration Matter?
(BioMed Central, 2001)
Airway hyperresponsiveness in asthma may not be a problem of too much airway smooth muscle strength. Rather, it may be a problem of too little of the factors that oppose muscle shortening. The weight of available evidence ...
Childhood infections and asthma: at the crossroads of the hygiene and Barker hypotheses
(BioMed Central, 2001)
The hygiene hypothesis states that childhood asthma develops as a result of decreased exposure to infectious agents during infancy and early childhood. This results in the persistence of the neonatal T helper lymphocyte 2 ...
Epidemiologic Evidence of Cardiovascular Effects of Particulate Air Pollution
(National Institute of Environmental Health Sciences, 2001)
In the past decade researchers have developed a body of epidemiologic evidence showing increased daily cardiovascular mortality and morbidity associated with acute exposures to particulate air pollution. Associations have ...
Model-based Analysis of Oligonucleotide Arrays: Model Validation, Design Issues and Standard Error Application
(BioMed Central, 2001)
Background: A model-based analysis of oligonucleotide expression arrays we developed previously uses a probe-sensitivity index to capture the response characteristic of a specific probe pair and calculates model-based ...
Bayesian Analysis of Haplotypes for Linkage Disequilibrium Mapping
(Cold Spring Harbor Laboratory Press, 2001)
Haplotype analysis of disease chromosomes can help identify probable historical recombination events and localize disease mutations. Most available analyses use only marginal and pairwise allele frequency information. We ...
Intranasal Immunization with Killed Unencapsulated Whole Cells Prevents Colonization and Invasive Disease by Capsulated Pneumococci
(American Society for Microbiology, 2001)
A whole-cell killed unencapsulated pneumococcal vaccine given by the intranasal route with cholera toxin as an adjuvant was tested in two animal models. This vaccination was highly effective in preventing nasopharyngeal ...
Visualizing Pneumococcal Infections in the Lungs of Live Mice Using Bioluminescent Streptococcus pneumoniae Transformed with a Novel Gram-Positive lux Transposon
(American Society for Microbiology, 2001)
Animal studies with Streptococcus pneumoniae have provided valuable models for drug development. In order to monitor long-term pneumococcal infections noninvasively in living mice, a novel gram-positive lux transposon ...
Phylogenetic footprinting of transcription factor binding sites in proteobacterial genomes
(Oxford University Press (OUP), 2001)
Toward the goal of identifying complete sets of transcription factor (TF)-binding sites in the genomes of several gamma proteobacteria, and hence describing their transcription regulatory networks, we present a phylogenetic ...
Physical Activity and Television Watching in Relation to Risk for Type 2 Diabetes Mellitus in Men
(American Medical Association, 2001)
Background: Television (TV) watching, a major sedentary behavior in the United States, has been associated with obesity. We hypothesized that prolonged TV watching may increase risk for type 2 diabetes. Methods: In 1986, ...
Fruit, Vegetables, Dietary Fiber, and Risk of Colorectal Cancer
(Oxford University Press, 2001)