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Dose–Response Relationship of Prenatal Mercury Exposure and IQ: An Integrative Analysis of Epidemiologic Data
(National Institute of Environmental Health Sciences, 2007)
Background: Prenatal exposure to mercury has been associated with adverse childhood neurologic outcomes in epidemiologic studies. Dose–response information for this relationship is useful for estimating benefits of reduced ...
Transcriptional Biomarkers of Steroidogenesis and Trophoblast Differentiation in the Placenta in Relation to Prenatal Phthalate Exposure
(National Institute of Environmental Health Sciences, 2009)
Background: Phthalates can alter steroidogenesis and peroxisome proliferator–activated receptor gamma (PPARγ)–mediated transcription in rodent tissues. The placenta offers a rich source of biomarkers to study these ...
Exposure to Bisphenol A and Other Phenols in Neonatal Intensive Care Unit Premature Infants
(National Institute of Environmental Health Sciences, 2008)
Objective: We previously demonstrated that exposure to polyvinyl chloride plastic medical devices containing di(2-ethylhexyl) phthalate (DEHP) was associated with higher urinary concentrations of several DEHP metabolites ...
Fungal Levels in the Home and Allergic Rhinitis by 5 Years of Age
(National Institute of Environmental Health Sciences, 2005)
Studies have repeatedly demonstrated that sensitization to fungi, such as Alternaria, is strongly associated with allergic rhinitis and asthma in children. However, the role of exposure to fungi in the development of ...
Predictors of Serum Dioxins and PCBs among Peripubertal Russian Boys
(National Institute of Environmental Health Sciences, 2009)
Background: Although sources and routes of exposure to dioxins and polychlorinated biphenyls (PCBs) have been studied, information regarding exposure among children is limited. Breast-feeding and diet are two important ...
Urinary Phthalate Metabolites in Relation to Preterm Birth in Mexico City
(National Institute of Environmental Health Sciences, 2009)
Background: Rates of preterm birth have been rising over the past several decades. Factors contributing to this trend remain largely unclear, and exposure to environmental contaminants may play a role. Objective: We ...
Fetal Lead Exposure at Each Stage of Pregnancy as a Predictor of Infant Mental Development
(National Institute of Environmental Health Sciences, 2006)
Background: The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure. Objective: We ...
Variants in iron metabolism genes predict higher blood lead levels in young children
(National Institute of Environmental Health Sciences, 2008)
Background: Given the association between iron deficiency and lead absorption, we hypothesized that variants in iron metabolism genes would predict higher blood lead levels in young children. Objective: We examined the ...
Maternal Fish Consumption, Hair Mercury, and Infant Cognition in a U.S. Cohort
(National Institute of Environmental Health Sciences, 2005)
Fish and other seafood may contain organic mercury but also beneficial nutrients such as n-3 polyunsaturated fatty acids. We endeavored to study whether maternal fish consumption during pregnancy harms or benefits fetal ...
Use of di(2-ethylhexyl) phthalate–containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants
(National Institute of Environmental Health Sciences, 2005)
Objective: Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer used in medical products made with polyvinyl chloride (PVC) plastic and may be toxic to humans. DEHP is lipophilic and binds non-covalently to PVC, allowing it ...