Now showing items 2344-2363 of 6362

    • Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome 

      Machiela, Mitchell J.; Zhou, Weiyin; Karlins, Eric; Sampson, Joshua N.; Freedman, Neal D.; Yang, Qi; Hicks, Belynda; Dagnall, Casey; Hautman, Christopher; Jacobs, Kevin B.; Abnet, Christian C.; Aldrich, Melinda C.; Amos, Christopher; Amundadottir, Laufey T.; Arslan, Alan A.; Beane-Freeman, Laura E.; Berndt, Sonja I.; Black, Amanda; Blot, William J.; Bock, Cathryn H.; Bracci, Paige M.; Brinton, Louise A.; Bueno-de-Mesquita, H Bas; Burdett, Laurie; Buring, Julie E.; Butler, Mary A.; Canzian, Federico; Carreón, Tania; Chaffee, Kari G.; Chang, I-Shou; Chatterjee, Nilanjan; Chen, Chu; Chen, Constance; Chen, Kexin; Chung, Charles C.; Cook, Linda S.; Crous Bou, Marta; Cullen, Michael; Davis, Faith G.; De Vivo, Immaculata; Ding, Ti; Doherty, Jennifer; Duell, Eric J.; Epstein, Caroline G.; Fan, Jin-Hu; Figueroa, Jonine D.; Fraumeni, Joseph F.; Friedenreich, Christine M.; Fuchs, Charles S.; Gallinger, Steven; Gao, Yu-Tang; Gapstur, Susan M.; Garcia-Closas, Montserrat; Gaudet, Mia M.; Gaziano, J. Michael; Giles, Graham G.; Gillanders, Elizabeth M.; Giovannucci, Edward L.; Goldin, Lynn; Goldstein, Alisa M.; Haiman, Christopher A.; Hallmans, Goran; Hankinson, Susan E.; Harris, Curtis C.; Henriksson, Roger; Holly, Elizabeth A.; Hong, Yun-Chul; Hoover, Robert N.; Hsiung, Chao A.; Hu, Nan; Hu, Wei; Hunter, David J.; Hutchinson, Amy; Jenab, Mazda; Johansen, Christoffer; Khaw, Kay-Tee; Kim, Hee Nam; Kim, Yeul Hong; Kim, Young Tae; Klein, Alison P.; Klein, Robert; Koh, Woon-Puay; Kolonel, Laurence N.; Kooperberg, Charles; Kraft, Peter; Krogh, Vittorio; Kurtz, Robert C.; LaCroix, Andrea; Lan, Qing; Landi, Maria Teresa; Marchand, Loic Le; Li, Donghui; Liang, Xiaolin; Liao, Linda M.; Lin, Dongxin; Liu, Jianjun; Lissowska, Jolanta; Lu, Lingeng; Magliocco, Anthony M.; Malats, Nuria; Matsuo, Keitaro; McNeill, Lorna H.; McWilliams, Robert R.; Melin, Beatrice S.; Mirabello, Lisa; Moore, Lee; Olson, Sara H.; Orlow, Irene; Park, Jae Yong; Patiño-Garcia, Ana; Peplonska, Beata; Peters, Ulrike; Petersen, Gloria M.; Pooler, Loreall; Prescott, Jennifer; Prokunina-Olsson, Ludmila; Purdue, Mark P.; Qiao, You-Lin; Rajaraman, Preetha; Real, Francisco X.; Riboli, Elio; Risch, Harvey A.; Rodriguez-Santiago, Benjamin; Ruder, Avima M.; Savage, Sharon A.; Schumacher, Fredrick; Schwartz, Ann G.; Schwartz, Kendra L.; Seow, Adeline; Wendy Setiawan, Veronica; Severi, Gianluca; Shen, Hongbing; Sheng, Xin; Shin, Min-Ho; Shu, Xiao-Ou; Silverman, Debra T.; Spitz, Margaret R.; Stevens, Victoria L.; Stolzenberg-Solomon, Rachael; Stram, Daniel; Tang, Ze-Zhong; Taylor, Philip R.; Teras, Lauren R.; Tobias, Geoffrey S.; Van Den Berg, David; Visvanathan, Kala; Wacholder, Sholom; Wang, Jiu-Cun; Wang, Zhaoming; Wentzensen, Nicolas; Wheeler, William; White, Emily; Wiencke, John K.; Wolpin, Brian M.; Wong, Maria Pik; Wu, Chen; Wu, Tangchun; Wu, Xifeng; Wu, Yi-Long; Wunder, Jay S.; Xia, Lucy; Yang, Hannah P.; Yang, Pan-Chyr; Yu, Kai; Zanetti, Krista A.; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Zhou, Baosen; Ziegler, Regina G.; Perez-Jurado, Luis A.; Caporaso, Neil E.; Rothman, Nathaniel; Tucker, Margaret; Dean, Michael C.; Yeager, Meredith; Chanock, Stephen J. (Nature Publishing Group, 2016)
      To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected ...
    • Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target 

      Yang, Zhiping; Huang, Yuh-Chin T; Koziel, Henry; de Crom, Rini; Ruetten, Hartmut; Wohlfart, Paulus; Thomsen, Reimar W; Kahlert, Johnny A; Sørensen, Henrik Toft; Jozefowski, Szczepan; Colby, Amy; Kobzik, Lester (eLife Sciences Publications, Ltd, 2014)
      To identify new approaches to enhance innate immunity to bacterial pneumonia, we investigated the natural experiment of gender differences in resistance to infections. Female and estrogen-treated male mice show greater ...
    • Ferristatin II Promotes Degradation of Transferrin Receptor-1 In Vitro and In Vivo 

      Byrne, Shaina L.; Buckett, Peter D.; Kim, Jonghan; Luo, Flora; Sanford, Jack; Chen, Juxing; Enns, Caroline; Wessling-Resnick, Marianne (Public Library of Science, 2013)
      Previous studies have shown that the small molecule iron transport inhibitor ferristatin (NSC30611) acts by down-regulating transferrin receptor-1 (TfR1) via receptor degradation. In this investigation, we show that another ...
    • Fertility Therapies, Infertility and Autism Spectrum Disorders in the Nurses’ Health Study II 

      Lyall, Kristen; Pauls, David L.; Spiegelman, Donna; Santangelo, Susan L.; Ascherio, Alberto (Wiley, 2012)
      Background: An increasing number of women are utilizing fertility treatments, but little is known about their relation to autism spectrum disorders (ASD). Methods: To determine the association between maternal fertility ...
    • Fetal Exposure to Parental Smoking and the Risk of Type 2 Diabetes in Adult Women 

      Jaddoe, Vincent W. V.; de Jonge, Layla L.; van Dam, Rob M.; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Harris, Holly; Stampfer, Meir; Hu, Frank B.; Michels, Karin B. (American Diabetes Association, 2014)
      OBJECTIVE We evaluated the associations of both maternal and paternal smoking during pregnancy with the risk of type 2 diabetes in daughters and explored whether any association was explained by weight at birth or BMI ...
    • Fetal Lead Exposure at Each Stage of Pregnancy as a Predictor of Infant Mental Development 

      Hu, Howard; Téllez-Rojo, Martha María; Lamadrid-Figueroa, Héctor; Schnaas, Lourdes; Mercado-García, Adriana; Hernández-Avila, Mauricio; Bellinger, David C.; Smith, Donald; Ettinger, Adrienne S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2006)
      Background: The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure. Objective: We ...
    • Fetal Window of Vulnerability to Airborne Polycyclic Aromatic Hydrocarbons on Proportional Intrauterine Growth Restriction 

      Choi, Hyunok; Wang, Lu; Lin, Xihong; Spengler, John D.; Perera, Frederica P. (Public Library of Science, 2012)
      Background: Although the entire duration of fetal development is generally considered a highly susceptible period, it is of public health interest to determine a narrower window of heightened vulnerability to polycyclic ...
    • Fetuin-A and risk of coronary heart disease: a Mendelian randomization analysis and a pooled analysis of AHSG genetic variants in 7 prospective studies 

      Laugsand, Lars; Ix, Joachim; Bartz, Traci; Djousse, Luc; Kizer, Jorge; Tracy, Russell; Dehghan, Abbas; Rexrode, Kathryn; Lopez, Oscar; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Siscovick, David; O'Donnell, Christopher J.; Newman, Anne; Mukamal, Kenneth; Jensen, Majken (Elsevier, 2015)
      Background and aims: Fetuin-A has a plausible role in the inhibition of arterial calcification, but its association with risk of coronary heart disease (CHD) in the general population is unclear. We used two common genetic ...
    • Fetuin-A, Type 2 Diabetes, and Risk of Cardiovascular Disease in Older Adults: The Cardiovascular Health Study 

      Jensen, Majken K.; Bartz, Traci M.; Mukamal, Kenneth J.; Djoussé, Luc; Kizer, Jorge R.; Tracy, Russell P.; Zieman, Susan J.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Siscovick, David S.; Shlipak, Michael; Ix, Joachim H. (American Diabetes Association, 2013)
      OBJECTIVE-Fetuin-A, a hepatic secretory protein that simultaneously inhibits arterial calcification and insulin action, is associated with type 2 diabetes, but its association with cardiovascular disease (CVD) is uncertain. ...
    • Few changes in food security and dietary intake from short-term participation in the Supplemental Nutrition Assistance Program among low-income Massachusetts adults 

      Leung, Cindy W.; Cluggish, Sarah; Villamor, Eduardo; Catalano, Paul J.; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 (2014)
      Objective: To examine whether short-term participation in the Supplemental Nutrition Assistance Program (SNAP) affects food security and dietary quality among low-income adults recruited from a Massachusetts-wide emergency ...
    • FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder 

      Guancial, Elizabeth A; Werner, Lillian; Bellmunt, Joaquim; Bamias, Aristotle; Choueiri, Toni K; Ross, Robert; Schutz, Fabio A; Park, Rachel S; O'Brien, Robert J; Hirsch, Michelle S; Barletta, Justine A; Berman, David M; Lis, Rosina; Loda, Massimo; Stack, Edward C; Garraway, Levi A; Riester, Markus; Michor, Franziska; Kantoff, Philip W; Rosenberg, Jonathan E (BlackWell Publishing Ltd, 2014)
      While fibroblast growth factor receptor 3 (FGFR3) is frequently mutated or overexpressed in nonmuscle-invasive urothelial carcinoma (UC), the prevalence of FGFR3 protein expression and mutation remains unknown in muscle-invasive ...
    • Fibroblast Growth Factor–23 and Cardiac Structure and Function 

      Agarwal, Isha; Ide, Noriko; Ix, Joachim H.; Kestenbaum, Bryan; Lanske, Beate; Schiller, Nelson B.; Whooley, Mary A.; Mukamal, Kenneth J. (Blackwell Publishing Ltd, 2014)
      Background: Fibroblast growth factor–23 (FGF‐23) is a phosphaturic factor previously associated with left ventricular hypertrophy and systolic dysfunction among individuals with chronic kidney disease. Whether FGF‐23 acts ...
    • Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks 

      Kim, Hyungjun; Kim, Jieun; Loggia, Marco L.; Cahalan, Christine; Garcia, Ronald G.; Vangel, Mark G.; Wasan, Ajay D.; Edwards, Robert R.; Napadow, Vitaly (Elsevier, 2015)
      Altered brain morphometry has been widely acknowledged in chronic pain, and recent studies have implicated altered network dynamics, as opposed to properties of individual brain regions, in supporting persistent pain. ...
    • Fibrosis-Related Biomarkers and Incident Cardiovascular Disease in Older Adults: The Cardiovascular Health Study 

      Agarwal, Isha; Glazer, Nicole; Barasch, Eddy; Biggs, Mary; Djousse, Luc; Fitzpatrick, Annette; Gottdiener, John; Ix, Joachim; Kizer, Jorge; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Sicovick, David; Tracy, Russell; Mukamal, Kenneth (2014)
      Background-Fibrotic changes in the heart and arteries have been implicated in a diverse range of cardiovascular diseases (CVD), but whether circulating biomarkers that reflect fibrosis are associated with CVD is unknown.Methods ...
    • Fibrosis-Related Biomarkers and Large and Small Vessel Disease: The Cardiovascular Health Study 

      Agarwal, Isha; Arnold, Alice; Glazer, Nicole; Barasch, Eddy; Djousse, Luc; Fitzpatrick, Annette; Gottdiener, John; Ix, Joachim; Jensen, Richard; Kizer, Jorge; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Sicovick, David; Tracy, Russell; Wong, Tien; Mukamal, Kenneth (Elsevier, 2015)
      Objective: Fibrosis has been implicated in a number of pathological, organ-based conditions of the liver, kidney, heart, and lungs. The objective of this study was to determine whether biomarkers of fibrosis are associated ...
    • Fibrosis-Related Biomarkers and Risk of Total and Cause-Specific Mortality: The Cardiovascular Health Study 

      Agarwal, Isha; Glazer, Nicole L.; Barasch, Eddy; Biggs, Mary L.; Djoussé, Luc; Fitzpatrick, Annette L.; Gottdiener, John S.; Ix, Joachim H.; Kizer, Jorge R.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Siscovick, David S.; Tracy, Russell P.; Zieman, Susan J.; Mukamal, Kenneth J. (Oxford University Press, 2014)
      Fibrosis has been implicated in diverse diseases of the liver, kidney, lungs, and heart, but its importance as a risk factor for mortality remains unconfirmed. We determined the prospective associations of 2 complementary ...
    • Fifty-Year Fate and Impact of General Medical Journals 

      Ioannidis, John; Belbasis, Lazaros; Evangelou, Evangelos (Public Library of Science, 2010)
      Background: Influential medical journals shape medical science and practice and their prestige is usually appraised by citation impact metrics, such as the journal impact factor. However, how permanent are medical journals ...
    • The Financial Impact of the ‘Zero-Markup Policy for Essential Drugs’ on Patients in County Hospitals in Western Rural China 

      Zhou, Zhongliang; Su, Yanfang; Campbell, Benjamin; Zhou, Zhiying; Gao, Jianmin; Yu, Qiang; Chen, Jiuhao; Pan, Yishan (Public Library of Science, 2015)
      Objective: With a quasi-experimental design, this study aims to assess whether the Zero-markup Policy for Essential Drugs (ZPED) reduces the medical expense for patients at county hospitals, the major healthcare provider ...
    • Financial Incentives for Return of Service in Underserved Areas: a Systematic Review 

      Bärnighausen, Till; Bloom, David E. (BioMed Central, 2009)
      Background: In many geographic regions, both in developing and in developed countries, the number of health workers is insufficient to achieve population health goals. Financial incentives for return of service are intended ...
    • Financing Essential HIV Services: A New Economic Agenda 

      Vassall, Anna; Remme, Michelle; Watts, Charlotte; Hallett, Timothy; Siapka, Mariana; Vickerman, Peter; Terris-Prestholt, Fern; Haacker, Markus; Heise, Lori; Haines, Andy; Atun, Rifat; Piot, Peter (Public Library of Science, 2013)
      Anna Vassall and colleagues discuss the need for, and challenges facing, innovative and sustainable financing of the HIV response. Please see later in the article for the Editors' Summary