Browsing SPH Scholarly Articles by Title

Now showing items 2569-2588 of 6362

    • Genetic Variability of the mTOR Pathway and Prostate Cancer Risk in the European Prospective Investigation on Cancer (EPIC) 

      Campa, Daniele; Stein, Angelika; Dostal, Lucie; Boeing, Heiner; Pischon, Tobias; Roswall, Nina; Overvad, Kim; Barricarte, Aurelio; Khaw, Kay-Tee; Wareham, Nicholas; Travis, Ruth C.; Allen, Naomi E.; Trichopoulou, Antonia; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Sacerdote, Carlotta; van Kranen, Henk; Bueno-de-Mesquita, H. Bas; Johansson, Mattias; Romieu, Isabelle; Jenab, Mazda; Siddiq, Afshan; Riboli, Elio; Canzian, Federico; Kaaks, Rudolf; Agoulnik, Irina; Hüsing, Anna; Tjønnelan, Anne; Østergaard, Jane Nautrup; Rodríguez, Laudina; Sala, Núria; Sánchez, Maria-José; Larrañaga, Nerea; Huerta, José-Maria; Hallmans, Göran; Cox, David G.; Lagiou, Pagona; Trichopoulos, Dimitrios (Public Library of Science, 2011)
      The mTOR (mammalian target of rapamycin) signal transduction pathway integrates various signals, regulating ribosome biogenesis and protein synthesis as a function of available energy and amino acids, and assuring an ...

    • Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study 

      Fesinmeyer, Megan D; Meigs, James B; North, Kari E; Schumacher, Fredrick R; Bůžková, Petra; Franceschini, Nora; Haessler, Jeffrey; Goodloe, Robert; Spencer, Kylee L; Voruganti, Venkata Saroja; Howard, Barbara V; Jackson, Rebecca; Kolonel, Laurence N; Liu, Simin; Manson, JoAnn E; Monroe, Kristine R; Mukamal, Kenneth; Dilks, Holli H; Pendergrass, Sarah A; Nato, Andrew; Wan, Peggy; Wilkens, Lynne R; Marchand, Loic Le; Ambite, José Luis; Buyske, Steven; Florez, Jose C; Crawford, Dana C; Hindorff, Lucia A; Haiman, Christopher A; Peters, Ulrike; Pankow, James S (BioMed Central, 2013)
      Background: Multiple genome-wide association studies (GWAS) within European populations have implicated common genetic variants associated with insulin and glucose concentrations. In contrast, few studies have been conducted ...

    • Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses 

      Okbay, Aysu; Baselmans, Bart M.L.; De Neve, Jan-Emmanuel; Turley, Patrick; Nivard, Michel G.; Fontana, Mark Alan; Meddens, S. Fleur W.; Linnér, Richard Karlsson; Rietveld, Cornelius A.; Derringer, Jaime; Gratten, Jacob; Lee, James J.; Liu, Jimmy Z.; de Vlaming, Ronald; Ahluwalia, Tarunveer S.; Buchwald, Jadwiga; Cavadino, Alana; Frazier-Wood, Alexis C.; Furlotte, Nicholas A.; Garfield, Victoria; Geisel, Marie Henrike; Gonzalez, Juan R.; Haitjema, Saskia; Karlsson, Robert; van der Laan, Sander W.; Ladwig, Karl-Heinz; Lahti, Jari; van der Lee, Sven J.; Lind, Penelope A.; Liu, Tian; Matteson, Lindsay; Mihailov, Evelin; Miller, Michael B.; Minica, Camelia C.; Nolte, Ilja M.; Mook-Kanamori, Dennis; van der Most, Peter J.; Oldmeadow, Christopher; Qian, Yong; Raitakari, Olli; Rawal, Rajesh; Realo, Anu; Rueedi, Rico; Schmidt, Börge; Smith, Albert V.; Stergiakouli, Evie; Tanaka, Toshiko; Taylor, Kent; Wedenoja, Juho; Wellmann, Juergen; Westra, Harm-Jan; Willems, Sara M.; Zhao, Wei; Amin, Najaf; Bakshi, Andrew; Boyle, Patricia A.; Cherney, Samantha; Cox, Simon R.; Davies, Gail; Davis, Oliver S.P.; Ding, Jun; Direk, Nese; Eibich, Peter; Emeny, Rebecca T.; Fatemifar, Ghazaleh; Faul, Jessica D.; Ferrucci, Luigi; Forstner, Andreas; Gieger, Christian; Gupta, Richa; Harris, Tamara B.; Harris, Juliette M.; Holliday, Elizabeth G.; Hottenga, Jouke-Jan; De Jager, Philip L.; Kaakinen, Marika A.; Kajantie, Eero; Karhunen, Ville; Kolcic, Ivana; Kumari, Meena; Launer, Lenore J.; Franke, Lude; Li-Gao, Ruifang; Koini, Marisa; Loukola, Anu; Marques-Vidal, Pedro; Montgomery, Grant W.; Mosing, Miriam A.; Paternoster, Lavinia; Pattie, Alison; Petrovic, Katja E.; Pulkki-Råback, Laura; Quaye, Lydia; Räikkönen, Katri; Rudan, Igor; Scott, Rodney J.; Smith, Jennifer A.; Sutin, Angelina R.; Trzaskowski, Maciej; Vinkhuyzen, Anna E.; Yu, Lei; Zabaneh, Delilah; Attia, John R.; Bennett, David A.; Berger, Klaus; Bertram, Lars; Boomsma, Dorret I.; Snieder, Harold; Chang, Shun-Chiao; Cucca, Francesco; Deary, Ian J.; van Duijn, Cornelia M.; Eriksson, Johan G.; Bültmann, Ute; de Geus, Eco J.C.; Groenen, Patrick J.F.; Gudnason, Vilmundur; Hansen, Torben; Hartman, Catharine A.; Haworth, Claire M.A.; Hayward, Caroline; Heath, Andrew C.; Hinds, David A.; Hyppönen, Elina; Iacono, William G.; Järvelin, Marjo-Riitta; Jöckel, Karl-Heinz; Kaprio, Jaakko; Kardia, Sharon L.R.; Keltikangas-Järvinen, Liisa; Kraft, Peter; Kubzansky, Laura D.; Lehtimäki, Terho; Magnusson, Patrik K.E.; Martin, Nicholas G.; McGue, Matt; Metspalu, Andres; Mills, Melinda; de Mutsert, Renée; Oldehinkel, Albertine J.; Pasterkamp, Gerard; Pedersen, Nancy L.; Plomin, Robert; Polasek, Ozren; Power, Christine; Rich, Stephen S.; Rosendaal, Frits R.; den Ruijter, Hester M.; Schlessinger, David; Schmidt, Helena; Svento, Rauli; Schmidt, Reinhold; Alizadeh, Behrooz Z.; Sørensen, Thorkild I.A.; Spector, Tim D.; Steptoe, Andrew; Terracciano, Antonio; Thurik, A. Roy; Timpson, Nicholas J.; Tiemeier, Henning; Uitterlinden, André G.; Vollenweider, Peter; Wagner, Gert G.; Weir, David R.; Yang, Jian; Conley, Dalton C.; Smith, George Davey; Hofman, Albert; Johannesson, Magnus; Laibson, David I.; Medland, Sarah E.; Meyer, Michelle N.; Pickrell, Joseph K.; Esko, Tõnu; Krueger, Robert F.; Beauchamp, Jonathan P.; Koellinger, Philipp D.; Benjamin, Daniel J.; Bartels, Meike; Cesarini, David (2016)
      We conducted genome-wide association studies of three phenotypes: subjective well-being (N = 298,420), depressive symptoms (N = 161,460), and neuroticism (N = 170,910). We identified three variants associated with subjective ...

    • Genetic Variants at Newly Identified Lipid Loci Are Associated with Coronary Heart Disease in a Chinese Han Population 

      Zhou, Li; Ding, Hu; Zhang, Xiaomin; He, Meian; Huang, Suli; Xu, Yujun; Shi, Ying; Cui, Guanglin; Cheng, Longxian; Wang, Qing K.; Hu, Frank B.; Wang, Daowen; Wu, Tangchun; Qin, Gangjian (Public Library of Science, 2011)
      Background: Recent genome-wide association studies (GWAS) have mapped several novel loci influencing blood lipid levels in Caucasians. We sought to explore whether the genetic variants at newly identified lipid-associated ...

    • Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes 

      Qi, Lu; Cornelis, Marilyn C.; Kraft, Peter; Jensen, Majken; Dam, Rob van; Sun, Qi; Girman, Cynthia J.; Laurie, Cathy C.; Mirel, Daniel B.; Hunter, David J.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Hu, Frank B. (Oxford University Press, 2010)
      Blood soluble E-selectin (sE-selectin) levels have been related to various conditions such as type 2 diabetes. We performed a genome-wide association study among women of European ancestry from the Nurses' Health Study, ...

    • Genetic variants in CETP increase risk of intracerebral hemorrhage 

      Anderson, Christopher D.; Falcone, Guido J.; Phuah, Chia‐Ling; Radmanesh, Farid; Brouwers, H. Bart; Battey, Thomas W. K.; Biffi, Alessandro; Peloso, Gina M.; Liu, Dajiang J.; Ayres, Alison M.; Goldstein, Joshua N.; Viswanathan, Anand; Greenberg, Steven M.; Selim, Magdy; Meschia, James F.; Brown, Devin L.; Worrall, Bradford B.; Silliman, Scott L.; Tirschwell, David L.; Flaherty, Matthew L.; Kraft, Peter; Jagiella, Jeremiasz M.; Schmidt, Helena; Hansen, Björn M.; Jimenez‐Conde, Jordi; Giralt‐Steinhauer, Eva; Elosua, Roberto; Cuadrado‐Godia, Elisa; Soriano, Carolina; van Nieuwenhuizen, Koen M.; Klijn, Catharina J. M.; Rannikmae, Kristiina; Samarasekera, Neshika; Salman, Rustam Al‐Shahi; Sudlow, Catherine L.; Deary, Ian J.; Morotti, Andrea; Pezzini, Alessandro; Pera, Joanna; Urbanik, Andrzej; Pichler, Alexander; Enzinger, Christian; Norrving, Bo; Montaner, Joan; Fernandez‐Cadenas, Israel; Delgado, Pilar; Roquer, Jaume; Lindgren, Arne; Slowik, Agnieszka; Schmidt, Reinhold; Kidwell, Chelsea S.; Kittner, Steven J.; Waddy, Salina P.; Langefeld, Carl D.; Abecasis, Goncalo; Willer, Cristen J.; Kathiresan, Sekar; Woo, Daniel; Rosand, Jonathan (John Wiley and Sons Inc., 2016)
      Objective: In observational epidemiologic studies, higher plasma high‐density lipoprotein cholesterol (HDL‐C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease ...

    • Genetic Variants in FGFR2 and FGFR4 Genes and Skin Cancer Risk in the Nurses' Health Study 

      Nan, Hongmei; Qureshi, Abrar A; Hunter, David J.; Han, Jiali (BioMed Central, 2009)
      Background: The human fibroblast growth factor (FGF) and its receptor (FGFR) play an important role in tumorigenesis. Deregulation of the FGFR2 gene has been identified in a number of cancer sites. Overexpression of the ...

    • Genetic Variants in the UGT1A6 Enzyme, Aspirin Use, and the Risk of Colorectal Adenoma 

      Chan, A. T.; Tranah, G. J.; Giovannucci, E. L.; Hunter, D. J.; Fuchs, C. S. (Oxford University Press, 2005)
      Genetic variation in the uridine diphosphate glucuronosyltransferase 1A6 (UGT1A6) enzyme is associated with impaired metabolism of aspirin. To determine whether polymorphisms in the UGT1A6 enzyme modulate the protective ...

    • Genetic variants of adiponectin and risk of colorectal cancer 

      Song, Mingyang; Gong, Jian; Giovannucci, Edward; Berndt, Sonja; Brenner, Hermann; Chang-Claude, Jenny; Curtis, Keith; Harrison, Tabitha; Hoffmeister, Michael; Hsu, Li; Jiao, Shuo; Le Marchand, Loic; Potter, John; Schoen, Robert; Seminara, Daniela; Slattery, Martha; White, Emily; Wu, Kana; Ogino, Shuji; Fuchs, Charles; Hunter, David; Tworoger, Shelley; Hu, Frank; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Jensen, Majken; Peters, Ulrike; Chan, Andrew (Wiley, 2015)
      Circulating adiponectin has been associated with lower risk of colorectal cancer (CRC). Genome-wide association studies have identified several single-nucleotide polymorphisms (SNPs) associated with adiponectin levels. ...

    • Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets 

      Rahmioglu, Nilufer; Nyholt, Dale R.; Morris, Andrew P.; Missmer, Stacey A.; Montgomery, Grant W.; Zondervan, Krina T. (Oxford University Press, 2014)
      BACKGROUND Endometriosis is a heritable common gynaecological condition influenced by multiple genetic and environmental factors. Genome-wide association studies (GWASs) have proved successful in identifying common genetic ...

    • Genetic Variation across C-Reactive Protein and Risk of Prostate Cancer 

      Markt, Sarah; Rider, Jennifer; Penney, Kathryn; Schumacher, Fredrick; Epstein, Mara; Fall, Katja; Sesso, Howard; Stampfer, Meir; Mucci, Lorelei (Wiley, 2014)
      BACKGROUND. Inflammation has been hypothesized to play an important etiological role in the initiation or progression of prostate cancer. Circulating levels of the systemic inflammation marker C-reactive protein (CRP) have ...

    • Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study 

      Johnson, Nichola; Dudbridge, Frank; Orr, Nick; Gibson, Lorna; Jones, Michael E; Schoemaker, Minouk J; Folkerd, Elizabeth J; Haynes, Ben P; Hopper, John L; Southey, Melissa C; Dite, Gillian S; Apicella, Carmel; Schmidt, Marjanka K; Broeks, Annegien; Van’t Veer, Laura J; Atsma, Femke; Muir, Kenneth; Lophatananon, Artitaya; Fasching, Peter A; Beckmann, Matthias W; Ekici, Arif B; Renner, Stefan P; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael; Miller, Nicola; Burwinkel, Barbara; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Guénel, Pascal; Truong, Therese; Cordina, Emilie; Menegaux, Florence; Bojesen, Stig E; Nordestgaard, Børge G; Flyger, Henrik; Milne, Roger; Zamora, M Pilar; Arias Perez, Jose Ignacio; Benitez, Javier; Bernstein, Leslie; Anton-Culver, Hoda; Ziogas, Argyrios; Clarke Dur, Christina; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Dieffenbach, Aida Karina; Meindl, Alfons; Heil, Joerg; Bartram, Claus R; Schmutzler, Rita K; Brauch, Hiltrud; Justenhoven, Christina; Ko, Yon-Dschun; Nevanlinna, Heli; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Matsuo, Keitaro; Dörk, Thilo; Bogdanova, Natalia V; Antonenkova, Natalia N; Lindblom, Annika; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Chenevix-Trench, Georgia; Beesley, Jonathan; Wu, Anna H; Van den Berg, David; Tseng, Chiu-Chen; Lambrechts, Diether; Smeets, Dominiek; Neven, Patrick; Wildiers, Hans; Chang-Claude, Jenny; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Radice, Paolo; Peterlongo, Paolo; Bonanni, Bernardo; Pensotti, Valeria; Couch, Fergus J; Olson, Janet E; Wang, Xianshu; Fredericksen, Zachary; Pankratz, Vernon S; Giles, Graham G; Severi, Gianluca; Baglietto, Laura; Haiman, Chris; Simard, Jacques; Goldberg, Mark S; Labrèche, France; Dumont, Martine; Soucy, Penny; Teo, Soo; Yip, Cheng Har; Phuah, Sze Yee; Cornes, Belinda K; Kristensen, Vessela N; Grenaker Alnæs, Grethe; Børresen-Dale, Anne-Lise; Zheng, Wei; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Andrulis, Irene L; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Devillee, Peter; Figueroa, Jonine; Chanock, Stephen J; Lissowska, Jolanta; Sherman, Mark E; Hall, Per; Schoof, Nils; Hooning, Maartje; Hollestelle, Antoinette; Oldenburg, Rogier A; Tilanus-Linthorst, Madeleine; Liu, Jianjun; Cox, Angie; Brock, Ian W; Reed, Malcolm WR; Cross, Simon S; Blot, William; Signorello, Lisa B; Pharoah, Paul DP; Dunning, Alison M; Shah, Mitul; Kang, Daehee; Noh, Dong-Young; Park, Sue K; Choi, Ji-Yeob; Hartman, Mikael; Miao, Hui; Lim, Wei Yen; Tang, Anthony; Hamann, Ute; Försti, Asta; Rüdiger, Thomas; Ulmer, Hans Ulrich; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Slager, Susan; Toland, Amanda E; Vachon, Celine; Yannoukakos, Drakoulis; Shen, Chen-Yang; Yu, Jyh-Cherng; Huang, Chiun-Sheng; Hou, Ming-Feng; González-Neira, Anna; Tessier, Daniel C; Vincent, Daniel; Bacot, Francois; Luccarini, Craig; Dennis, Joe; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Jean; Easton, Douglas F; García-Closas, Montserrat; Dowsett, Mitch; Ashworth, Alan; Swerdlow, Anthony J; Peto, Julian; dos Santos Silva, Isabel; Fletcher, Olivia (BioMed Central, 2014)
      Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and ...

    • Genetic Variation in Alcohol Dehydrogenase and the Beneficial Effect of Moderate Alcohol Consumption on Myocardial Infarction 

      Hines, Lisa M.; Stampfer, Meir; Ma, Jing; Gaziano, J. Michael; Ridker, Paul M.; Hankinson, Susan E.; Sacks, Frank; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Hunter, David J. (Massachusetts Medical Society, 2001)
      Background: A polymorphism in the gene for alcohol dehydrogenase type 3 (ADH3) alters the rate of alcohol metabolism. We investigated the relation among the ADH3 polymorphism, the level of alcohol consumption, and the risk ...

    • Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome 

      Hall, Kathryn T.; Kossowsky, Joe; Oberlander, Tim F.; Kaptchuk, Ted J.; Saul, J. Philip; Wyller, Vegard Bruun; Fagermoen, Even; Sulheim, Dag; Gjerstad, Johannes; Winger, Anette; Mukamal, Kenneth J. (2016)
      Clonidine, an α2-adrenergic receptor agonist, decreases circulating norepinephrine and epinephrine, attenuating sympathetic activity. Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors ...

    • Genetic variation in fatty acid elongases is not associated with intermediate cardiovascular phenotypes or myocardial infarction 

      Aslibekyan, S.; Jensen, M. K.; Campos, H.; Linkletter, C. D.; Loucks, E. B.; Ordovas, J. M.; Deka, R.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Baylin, A. (2012)
      BACKGROUND/OBJECTIVES: Elongases 2, 4 and 5, encoded by genes ELOVL2, ELOVL4 and ELOVL5, have a key role in the biosynthesis of very long chain polyunsaturated fatty acids (PUFAs). To date, few studies have investigated ...

    • Genetic variation in RNASEL associated with prostate cancer risk and progression 

      Meyer, Mara S.; Penney, Kathryn L.; Stark, Jennifer R.; Schumacher, Fredrick R.; Sesso, Howard D.; Loda, Massimo; Fiorentino, Michelangelo; Finn, Stephen; Flavin, Richard J.; Kurth, Tobias; Price, Alkes L.; Giovannucci, Edward L.; Fall, Katja; Stampfer, Meir; Ma, Jing; Mucci, Lorelei A. (Oxford University Press, 2010)
      Variation in genes contributing to the host immune response may mediate the relationship between inflammation and prostate carcinogenesis. RNASEL at chromosome 1q25 encodes ribonuclease L, part of the interferon-mediated ...

    • Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women 

      Lin, Jennifer; Zee, Robert Y. L.; Liu, Kuang-Yu; Zhang, Shumin M.; Lee, I-Min; Manson, JoAnn E.; Giovannucci, Edward; Buring, Julie E.; Cook, Nancy R. (Springer (part of Springer Nature), 2010)
      Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which sex hormones affect colorectal cancer development remain unknown. We sought ...

    • Genetic Variation in the Base Excision Repair Pathway, Environmental Risk Factors, and Colorectal Adenoma Risk 

      Corral, Roman; Lewinger, Juan Pablo; Joshi, Amit D.; Levine, A. Joan; Vandenberg, David J.; Haile, Robert W.; Stern, Mariana C. (Public Library of Science, 2013)
      Cigarette smoking, high alcohol intake, and low dietary folate levels are risk factors for colorectal adenomas. Oxidative damage caused by these three factors can be repaired through the base excision repair pathway (BER). ...

    • Genetic Variation in the Estrogen Metabolic Pathway and Mammographic Density as an Intermediate Phenotype of Breast Cancer 

      Li, Jingmei; Eriksson, Louise; Humphreys, Keith; Czene, Kamila; Liu, Jianjun; Lindström, Sara; Vachon, Celine M; Couch, Fergus J; Scott, Christopher G; Hall, Per; Tamimi, Rulla May; Hunter, David J.; Lagiou, Pagona (BioMed Central, 2010)
      Introduction: Several studies have examined the effect of genetic variants in genes involved in the estrogen metabolic pathway on mammographic density, but the number of loci studied and the sample sizes evaluated have ...

    • Genetic variation in the Toll-Like Receptor 4 and prostate cancer incidence and mortality 

      Shui, Irene M.; Stark, Jennifer R.; Penney, Kathryn L.; Schumacher, Fredrick R.; Epstein, Mara M.; Pitt, Michael J.; Stampfer, Meir; Tamimi, Rulla M.; Lindstrom, Sara; Sesso, Howard D.; Fall, Katja; Ma, Jing; Kraft, Peter; Giovannucci, Edward; Mucci, Lorelei A. (Wiley, 2012)
      BACKGROUND Common genetic variants in the Toll-like receptor 4 (TLR4), which is involved in inflammation and immune response pathways, may be important for prostate cancer.METHODS. In a large nested case-control study of ...