Browsing SPH Scholarly Articles by Title

Now showing items 2652-2671 of 6362

    • A genome-wide association study of marginal zone lymphoma shows association to the HLA region 

      Vijai, Joseph; Wang, Zhaoming; Berndt, Sonja I.; Skibola, Christine F.; Slager, Susan L.; de Sanjose, Silvia; Melbye, Mads; Glimelius, Bengt; Bracci, Paige M.; Conde, Lucia; Birmann, Brenda M.; Wang, Sophia S.; Brooks-Wilson, Angela R.; Lan, Qing; de Bakker, Paul I. W.; Vermeulen, Roel C. H.; Portlock, Carol; Ansell, Stephen M.; Link, Brian K.; Riby, Jacques; North, Kari E.; Gu, Jian; Hjalgrim, Henrik; Cozen, Wendy; Becker, Nikolaus; Teras, Lauren R.; Spinelli, John J.; Turner, Jenny; Zhang, Yawei; Purdue, Mark P.; Giles, Graham G.; Kelly, Rachel S.; Zeleniuch-Jacquotte, Anne; Ennas, Maria Grazia; Monnereau, Alain; Bertrand, Kimberly A.; Albanes, Demetrius; Lightfoot, Tracy; Yeager, Meredith; Chung, Charles C.; Burdett, Laurie; Hutchinson, Amy; Lawrence, Charles; Montalvan, Rebecca; Liang, Liming; Huang, Jinyan; Ma, Baoshan; Villano, Danylo J.; Maria, Ann; Corines, Marina; Thomas, Tinu; Novak, Anne J.; Dogan, Ahmet; Liebow, Mark; Thompson, Carrie A.; Witzig, Thomas E.; Habermann, Thomas M.; Weiner, George J.; Smith, Martyn T.; Holly, Elizabeth A.; Jackson, Rebecca D.; Tinker, Lesley F.; Ye, Yuanqing; Adami, Hans-Olov; Smedby, Karin E.; De Roos, Anneclaire J.; Hartge, Patricia; Morton, Lindsay M.; Severson, Richard K.; Benavente, Yolanda; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; McKay, James; Staines, Anthony; Diver, W. Ryan; Vajdic, Claire M.; Armstrong, Bruce K.; Kricker, Anne; Zheng, Tongzhang; Holford, Theodore R.; Severi, Gianluca; Vineis, Paolo; Ferri, Giovanni M.; Ricco, Rosalia; Miligi, Lucia; Clavel, Jacqueline; Giovannucci, Edward; Kraft, Peter; Virtamo, Jarmo; Smith, Alex; Kane, Eleanor; Roman, Eve; Chiu, Brian C. H.; Fraumeni, Joseph F.; Wu, Xifeng; Cerhan, James R.; Offit, Kenneth; Chanock, Stephen J.; Rothman, Nathaniel; Nieters, Alexandra (Nature Pub. Group, 2015)
      Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci ...

    • A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study 

      Granada, Mark; Wilk, Jemma; Tuzova, Marina; Strachan, David P.; Weidinger, Stephan; Albrecht, Eva; Gieger, Christian; Heinrich, Joachim; Himes, Blanca; Hunninghake, Gary Matthew; Celedón, Juan C.; Weiss, Scott Tillman; Cruikshank, William W.; Farrer, Lindsay A.; Center, David M.; O'Connor, George T. (Elsevier BV, 2012)
      Background— Atopy and plasma IgE concentration are genetically complex traits, and the specific genetic risk factors that lead to IgE dysregulation and clinical atopy are an area of active investigation. Objective— To ...

    • Genome-wide Association Study of Prostate Cancer Mortality 

      Penney, Kathryn L.; Pyne, Saumyadipta; Schumacher, Fredrick R.; Sinnott, Jennifer A.; Mucci, Lorelei A.; Kraft, Peter; Ma, Jing; Oh, William K.; Kurth, Tobias; Kantoff, Philip W.; Giovannucci, Edward L.; Stampfer, Meir; Hunter, David J.; Freedman, Matthew L. (American Association for Cancer Research, 2010)
      Background: A pressing clinical issue in prostate cancer is to distinguish which men will have an indolent or aggressive course of disease. Clinical variables such as Gleason grade and stage are useful predictors of lethal ...

    • Genome-wide association study of prostate cancer-specific survival 

      Szulkin, Robert; Karlsson, Robert; Whitington, Thomas; Aly, Markus; Gronberg, Henrik; Eeles, Rosalind; Easton, Douglas; Kote-Jarai, Zsofia; Olama, Ali Amin Al; Benlloch, Sara; Muir, Kenneth; Giles, Graham; Southey, Melissa; FitzGerald, Liesel; Henderson, Brian; Schumacher, Fredrick; Haiman, Christopher; Sipeky, Csilla; Tammela, Teuvo L. J.; Nordestgaard, Børge G.; Key, Timothy; Travis, Ruth; Neal, David; Donovan, Jenny; Hamdy, Freddie; Pharoah, Paul D. P.; Pashayan, Nora; Khaw, Kay-Tee; Stanford, Janet; Thibodeau, Stephen; McDonnell, Shannon; Schaid, Daniel; Maier, Christiane; Vogel, Walther; Luedeke, Manuel; Herkommer, Kathleen; Kibel, Adam; Cybulski, Cezary; Lubiński, Jan; Kluźniak, Wojciech; Cannon-Albright, Lisa; Brenner, Hermann; Herrmann, Volker; Holleczek, Bernd; Park, Jong; Sellers, Thomas; Lim, Hui-Yi; Slavov, Chavdar; Kaneva, Radka; Mitev, Vanio; Spurdle, Amanda; Teixeira, Manuel; Paulo, Paula; Maia, Sofia; Pandha, Hardev; Michael, Agnieszka; Kierzek, Andrzej; Batra, Jyotsna; Clements, Judith; Albanes, Demetrius; Andriole, Gerald; Berndt, Sonja; Chanock, Stephen; Gapstur, Susan; Giovannucci, Edward; Hunter, David; Kraft, Peter; Le Marchand, Loic; Ma, Jing; Mondul, Alison; Penney, Kathryn; Stampfer, Meir; Stevens, Victoria; Weinstein, Stephanie; Trichopoulou, Antonia; Bueno-de-Mesquita, Bas; Tjonneland, Anne; Cox, David; Maehle, Lovise; Schleutker, Johanna; Lindström, Sara; Wiklund, Fredrik (American Association for Cancer Research, 2015)
      Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: ...

    • A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study 

      Walter, Robert E.; Nagle, Michael W.; Brandler, Brian J.; Borecki, Ingrid B.; O'Connor, George T.; McCarthy, Mark I.; Wilk, Jemma B; Chen, Ting-Hsu; Gottlieb, Daniel J; Myers, Richard Hepworth; Silverman, Edwin Kepner; Weiss, Scott Tillman (Public Library of Science, 2009)
      The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a measure used to diagnose airflow obstruction and is highly heritable. We performed a genome-wide association study in 7,691 ...

    • Genome-wide association study of selenium concentrations 

      Cornelis, Marilyn; Fornage, Myriam; Foy, Millennia; Xun, Pengcheng; Gladyshev, Vadim; Morris, Steve; Chasman, Daniel; Hu, Frank; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Kraft, Peter; Jordan, Joanne; Mozaffarian, Dariush; He, Ka (Oxford University Press, 2015)
      Selenium (Se) is an essential trace element in human nutrition, but its role in certain health conditions, particularly among Se sufficient populations, is controversial. A genome-wide association study (GWAS) of blood Se ...

    • Genome-Wide Association Study of Survival in Patients with Pancreatic Adenocarcinoma 

      Wu, Chen; Kraft, Peter; Stolzenberg-Solomon, Rachael; Steplowski, Emily; Brotzman, Michelle; Xu, Mousheng; Mudgal, Poorva; Amundadottir, Laufey; Arslan, Alan A.; Bueno-de-Mesquita, H. Bas; Gross, Myron; Helzlsouer, Kathy; Jacobs, Eric J.; Kooperberg, Charles; Petersen, Gloria M.; Zheng, Wei; Albanes, Demetrius; Boutron-Ruault, Marie-Christine; Buring, Julie E.; Canzian, Federico; Cao, Guangwen; Duell, Eric J.; Elena, Joanne L.; Gaziano, J. Michael; Giovannucci, Edward L.; Hallmans, Göran; Hutchinson, Amy; Hunter, David J.; Jenab, Mazda; Jiang, Guoliang; Khaw, Kay-Tee; LaCroix, Andrea; Li, Zhaoshen; Mendelsohn, Julie B.; Panico, Salvatore; Patel, Alpa V.; Qian, Zhirong; Sesso, Howard; Shen, Hongbing; Shu, Xiao-Ou; Tjonneland, Anne; Tobias, Geoffrey S.; Trichopoulos, Dimitrios; Virtamo, Jarmo; Visvanathan, Kala; Wactawski-Wende, Jean; Wang, Chengfeng; Yu, Kai; Zeleniuch-Jacquotte, Anne; Chanock, Stephen; Hoover, Robert; Hartge, Patricia; Fuchs, Charles S.; Lin, Dongxin; Wolpin, Brian M. (BMJ Publishing Group, 2014)
      Background: and objective Survival of patients with pancreatic adenocarcinoma is limited and few prognostic factors are known. We conducted a two-stage genome-wide association study (GWAS) to identify germline variants ...

    • Genome-wide association study of susceptibility loci for breast cancer in Sardinian population 

      Palomba, Grazia; Loi, Angela; Porcu, Eleonora; Cossu, Antonio; Zara, Ilenia; Budroni, Mario; Dei, Mariano; Lai, Sandra; Mulas, Antonella; Olmeo, Nina; Ionta, Maria Teresa; Atzori, Francesco; Cuccuru, Gianmauro; Pitzalis, Maristella; Zoledziewska, Magdalena; Olla, Nazario; Lovicu, Mario; Pisano, Marina; Abecasis, Gonçalo R.; Uda, Manuela; Tanda, Francesco; Michailidou, Kyriaki; Easton, Douglas F.; Chanock, Stephen J.; Hoover, Robert N.; Hunter, David J.; Schlessinger, David; Sanna, Serena; Crisponi, Laura; Palmieri, Giuseppe (BioMed Central, 2015)
      Background: Despite progress in identifying genes associated with breast cancer, many more risk loci exist. Genome-wide association analyses in genetically-homogeneous populations, such as that of Sardinia (Italy), could ...

    • Genome-wide association study of the age of onset of childhood asthma 

      Forno, Erick; Lasky-Su, Jessica A. Lasky; Himes, Blanca; Howrylak, Judie; Ramsey, Clare; Brehm, John; Klanderman, Barbara; Ziniti, John; Melén, Erik; Pershagen, Goran; Wickman, Magnus; Martinez, Fernando; Mauger, Dave; Sorkness, Christine; Tantisira, Kelan; Raby, Benjamin Alexander; Weiss, Scott Tillman; Celedón, Juan C. (Elsevier BV, 2012)
      BACKGROUND: Childhood asthma is a complex disease with known heritability and phenotypic diversity. Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study ...

    • Genome-wide association study of Tourette Syndrome 

      Scharf, Jeremiah M.; Yu, Dongmei; Mathews, Carol A.; Neale, Benjamin M.; Stewart, S. Evelyn; Fagerness, Jesen A; Evans, Patrick; Gamazon, Eric; Edlund, Christopher K.; Service, Susan; Tikhomirov, Anna; Osiecki, Lisa; Illmann, Cornelia; Pluzhnikov, Anna; Konkashbaev, Anuar; Davis, Lea K; Han, Buhm; Crane, Jacquelyn; Moorjani, Priya; Crenshaw, Andrew T.; Parkin, Melissa A.; Reus, Victor I.; Lowe, Thomas L.; Rangel-Lugo, Martha; Chouinard, Sylvain; Dion, Yves; Girard, Simon; Cath, Danielle C; Smit, Jan H; King, Robert A.; Fernandez, Thomas; Leckman, James F.; Kidd, Kenneth K.; Kidd, Judith R.; Pakstis, Andrew J.; State, Matthew; Herrera, Luis Diego; Romero, Roxana; Fournier, Eduardo; Sandor, Paul; Barr, Cathy L; Phan, Nam; Gross-Tsur, Varda; Benarroch, Fortu; Pollak, Yehuda; Budman, Cathy L.; Bruun, Ruth D.; Erenberg, Gerald; Naarden, Allan L; Lee, Paul C; Weiss, Nicholas; Kremeyer, Barbara; Berrío, Gabriel Bedoya; Campbell, Desmond; Silgado, Julio C. Cardona; Ochoa, William Cornejo; Restrepo, Sandra C. Mesa; Muller, Heike; Duarte, Ana V. Valencia; Lyon, Gholson J; Leppert, Mark; Morgan, Jubel; Weiss, Robert; Grados, Marco A.; Anderson, Kelley; Davarya, Sarah; Singer, Harvey; Walkup, John; Jankovic, Joseph; Tischfield, Jay A.; Heiman, Gary A.; Gilbert, Donald L.; Hoekstra, Pieter J.; Robertson, Mary M.; Kurlan, Roger; Liu, Chunyu; Gibbs, J. Raphael; Singleton, Andrew; Hardy, John; Strengman, Eric; Ophoff, Roel; Wagner, Michael; Moessner, Rainald; Mirel, Daniel B.; Posthuma, Danielle; Sabatti, Chiara; Eskin, Eleazar; Conti, David V.; Knowles, James A.; Ruiz-Linares, Andres; Rouleau, Guy A.; Purcell, Shaun; Heutink, Peter; Oostra, Ben A.; McMahon, William; Freimer, Nelson; Cox, Nancy J.; Pauls, David L. (2012)
      Tourette Syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility ...

    • A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium 

      McKay, James D.; Truong, Therese; Gaborieau, Valerie; Chabrier, Amelie; Chuang, Shu-Chun; Byrnes, Graham; Zaridze, David; Shangina, Oxana; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Bucur, Alexandru; Bencko, Vladimir; Holcatova, Ivana; Janout, Vladimir; Foretova, Lenka; Benhamou, Simone; Bouchardy, Christine; Ahrens, Wolfgang; Merletti, Franco; Richiardi, Lorenzo; Talamini, Renato; Barzan, Luigi; Kjaerheim, Kristina; Macfarlane, Gary J.; Macfarlane, Tatiana V.; Simonato, Lorenzo; Canova, Cristina; Agudo, Antonio; Lowry, Ray; Conway, David I.; McKinney, Patricia A.; Toner, Mary E.; Znaor, Ariana; Curado, Maria Paula; Koifman, Sergio; Menezes, Ana; Boccia, Stefania; Cadoni, Gabriella; Arzani, Dario; Olshan, Andrew F.; Weissler, Mark C.; Funkhouser, William K.; Luo, Jingchun; Trubicka, Joanna; Lener, Marcin; Oszutowska, Dorota; Schwartz, Stephen M.; Fish, Sherianne; Doody, David R.; Muscat, Joshua E.; Lazarus, Philip; Gallagher, Carla J.; Chang, Shen-Chih; Zhang, Zuo-Feng; Wei, Qingyi; Sturgis, Erich M.; Wang, Li-E; Franceschi, Silvia; Herrero, Rolando; Kelsey, Karl T.; McClean, Michael D.; Marsit, Carmen J.; Nelson, Heather H.; Romkes, Marjorie; Buch, Shama; Nukui, Tomoko; Zhong, Shilong; Lacko, Martin; Manni, Johannes J.; Peters, Wilbert H. M.; Hung, Rayjean J.; Goodman, Gary E.; Liloglou, Triantafillos; Vineis, Paolo; Clavel-Chapelon, Francoise; Palli, Domenico; Tumino, Rosario; Krogh, Vittorio; Panico, Salvatore; Navarro, Carmen; Ardanaz, Eva; Khaw, Kay-Tee; Key, Timothy; Bueno-de-Mesquita, H. Bas; Peeters, Petra H. M.; Trichopoulou, Antonia; Linseisen, Jakob; Boeing, Heiner; Overvad, Kim; Kumle, Merethe; Riboli, Elio; Metspalu, Andres; Zelenika, Diana; Boland, Anne; Delepine, Marc; Foglio, Mario; Lechner, Doris; Gut, Ivo G.; Galan, Pilar; Heath, Simon; Hashibe, Mia; Hayes, Richard B.; Lathrop, Mark; Brennan, Paul; Horwitz, Marshall S.; Lagiou, Pagona; Trichopoulos, Dimitrios; Castellsagué, Xavier; Wünsch-Filho, Victor; Neto, José Eluf; Garrote, Leticia Fernández; Lubiński, Jan; Chen, Chu; McLaughin, John; Vatten, Lars Johan; Njølstad, Inger; Field, John K; González, Carlos A; Quirós, J. Ramón; Martínez, Carmen; Larrañaga, Nerea; Hallmans, Göran; Tjønneland, Anne; Välk, Kristjan; Vooder, Tõnu; Blanché, Hélène; Boffetta, Paolo (Public Library of Science, 2011)
      Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation ...

    • Genome-wide association study on serum alkaline phosphatase levels in a Chinese population 

      Li, Jun; Gui, Lixuan; Wu, Chen; He, Yunfeng; Zhou, Li; Guo, Huan; Yuan, Jing; Yang, Binyao; Dai, Xiayun; Deng, Qifei; Huang, Suli; Guan, Lei; Hu, Die; Deng, Siyun; Wang, Tian; Zhu, Jiang; Min, Xinwen; Lang, Mingjian; Li, Dongfeng; Yang, Handong; Hu, Frank B; Lin, Dongxin; Wu, Tangchun; He, Meian (BioMed Central, 2013)
      Background: Serum alkaline phosphatase (ALP) is a complex phenotype influenced by both genetic and environmental factors. Recent Genome-Wide Association Studies (GWAS) have identified several loci affecting ALP levels; ...

    • Genome-wide association study reveals class I MHC–restricted T cell–associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations 

      Du, Rose; Litonjua, Augusto Ampil; Tantisira, Kelan; Lasky-Su, Jessica A. Lasky; Sunyaev, Shamil R.; Klanderman, Barbara; Celedón, Juan C.; Avila, Lydiana; Soto-Quiros, Manuel E.; Weiss, Scott Tillman (Elsevier BV, 2012)
      Background— It has recently been shown that vitamin D deficiency can increase asthma development and severity and that variations in vitamin D receptor genes are associated with asthma susceptibility. Objective— We sought ...

    • Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia 

      Legge, Sophie E; Hamshere, Marian L; Ripke, Stephan; Pardinas, Antonio F; Goldstein, Jacqueline I; Rees, Elliott; Richards, Alexander L; Leonenko, Ganna; Jorskog, L Fredrik; Chambert, Kimberly D; Collier, David A; Genovese, Giulio; Giegling, Ina; Holmans, Peter; Jonasdottir, Adalbjorg; Kirov, George; McCarroll, Steven A; MacCabe, James H; Mantripragada, Kiran; Moran, Jennifer L; Neale, Benjamin M; Stefansson, Hreinn; Rujescu, Dan; Daly, Mark J; Sullivan, Patrick F; Owen, Michael J; O’Donovan, Michael C; Walters, James T R (2016)
      The antipsychotic clozapine is uniquely effective in the management of schizophrenia, but its use is limited by its potential to induce agranulocytosis. The causes of this, and of its precursor neutropenia, are largely ...

    • A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases 

      Zhu, Zhaozhong; Lee, Phil Hyoun; Chaffin, Mark; Chung, Wonil; Loh, Po-Ru; Lu, Quan; Christiani, David Christopher; Liang, Liming (Springer Science and Business Media LLC, 2018-05-21)
      Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma and allergic diseases in 33,593 cases and ...

    • Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer 

      Figueiredo, Jane C.; Hsu, Li; Hutter, Carolyn M.; Lin, Yi; Campbell, Peter T.; Baron, John A.; Berndt, Sonja I.; Jiao, Shuo; Casey, Graham; Fortini, Barbara; Chan, Andrew T.; Cotterchio, Michelle; Lemire, Mathieu; Gallinger, Steven; Harrison, Tabitha A.; Le Marchand, Loic; Newcomb, Polly A.; Slattery, Martha L.; Caan, Bette J.; Carlson, Christopher S.; Zanke, Brent W.; Rosse, Stephanie A.; Brenner, Hermann; Giovannucci, Edward L.; Wu, Kana; Chang-Claude, Jenny; Chanock, Stephen J.; Curtis, Keith R.; Duggan, David; Gong, Jian; Haile, Robert W.; Hayes, Richard B.; Hoffmeister, Michael; Hopper, John L.; Jenkins, Mark A.; Kolonel, Laurence N.; Qu, Conghui; Rudolph, Anja; Schoen, Robert E.; Schumacher, Fredrick R.; Seminara, Daniela; Stelling, Deanna L.; Thibodeau, Stephen N.; Thornquist, Mark; Warnick, Greg S.; Henderson, Brian E.; Ulrich, Cornelia M.; Gauderman, W. James; Potter, John D.; White, Emily; Peters, Ulrike (Public Library of Science, 2014)
      Dietary factors, including meat, fruits, vegetables and fiber, are associated with colorectal cancer; however, there is limited information as to whether these dietary factors interact with genetic variants to modify risk ...

    • Genome-Wide Diversity in the Levant Reveals Recent Structuring by Culture 

      Haber, Marc; Gauguier, Dominique; Youhanna, Sonia; Patterson, Nick; Moorjani, Priya; Botigué, Laura R.; Platt, Daniel E.; Matisoo-Smith, Elizabeth; Soria-Hernanz, David F.; Wells, R. Spencer; Bertranpetit, Jaume; Tyler-Smith, Chris; Comas, David; Zalloua, Pierre A. (Public Library of Science, 2013)
      The Levant is a region in the Near East with an impressive record of continuous human existence and major cultural developments since the Paleolithic period. Genetic and archeological studies present solid evidence placing ...

    • Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci 

      Rahmioglu, Nilufer; Macgregor, Stuart; Drong, Alexander W.; Hedman, Åsa K.; Harris, Holly R.; Randall, Joshua C.; Prokopenko, Inga; Nyholt, Dale R.; Morris, Andrew P.; Montgomery, Grant W.; Missmer, Stacey A.; Lindgren, Cecilia M.; Zondervan, Krina T. (2015)
      Endometriosis is a chronic inflammatory condition in women that results in pelvic pain and subfertility, and has been associated with decreased body mass index (BMI). Genetic variants contributing to the heritable component ...

    • Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity 

      Sordillo, Joanne; Kelly, Roxanne; Bunyavanich, Supinda; McGeachie, Michael John; Qiu, Weiliang; Croteau-Chonka, Damien C; Soto-Quiros, Manuel; Avila, Lydiana; Celedón, Juan C.; Brehm, John M.; Weiss, Scott Tillman; Gold, Diane R.; Litonjua, Augusto Ampil (Elsevier BV, 2015)
      Background: Gene by environment interaction (G × E) studies utilizing GWAS data are often underpowered after adjustment for multiple comparisons. Differential gene expression, in response to the exposure of interest, may ...

    • Genome-wide identification of microRNA-related variants associated with risk of Alzheimer’s disease 

      Ghanbari, Mohsen; Ikram, M. Arfan; de Looper, Hans W. J.; Hofman, Albert; Erkeland, Stefan J.; Franco, Oscar H.; Dehghan, Abbas (Nature Publishing Group, 2016)
      MicroRNAs (miRNAs) serve as key post-transcriptional regulators of gene expression. Genetic variation in miRNAs and miRNA-binding sites may affect miRNA function and contribute to disease risk. Here, we investigated the ...