Browsing SPH Scholarly Articles by Title
Now showing items 2670-2689 of 6362
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Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity
(Elsevier BV, 2015)Background: Gene by environment interaction (G × E) studies utilizing GWAS data are often underpowered after adjustment for multiple comparisons. Differential gene expression, in response to the exposure of interest, may ... -
Genome-wide identification of microRNA-related variants associated with risk of Alzheimer’s disease
(Nature Publishing Group, 2016)MicroRNAs (miRNAs) serve as key post-transcriptional regulators of gene expression. Genetic variation in miRNAs and miRNA-binding sites may affect miRNA function and contribute to disease risk. Here, we investigated the ... -
Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer
(Public Library of Science, 2016)Genome-wide association studies (GWAS) have identified many genetic susceptibility loci for colorectal cancer (CRC). However, variants in these loci explain only a small proportion of familial aggregation, and there are ... -
Genome-wide interaction study of smoking and bladder cancer risk
(Oxford University Press, 2014)Bladder cancer is a complex disease with known environmental and genetic risk factors. We performed a genome-wide interaction study (GWAS) of smoking and bladder cancer risk based on primary scan data from 3002 cases and ... -
Genome-Wide Interrogation of Longitudinal FEV 1 in Children With Asthma
(American Thoracic Society, 2014)Rationale: Most genomic studies of lung function have used phenotypic data derived from a single time-point (e.g., presence/absence of disease) without considering the dynamic progression of a chronic disease. Objectives: ... -
Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
(Public Library of Science, 2012)Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second \((FEV_1)\), and its ratio to forced vital capacity \((FEV_1/FVC)\). ... -
Genome-Wide Linkage Analysis of Longitudinal Phenotypes Using σ2A Random Effects (SSARs) Fitted By Gibbs Sampling
(BioMed Central, 2003)The study of change in intermediate phenotypes over time is important in genetics. In this paper we explore a new approach to phenotype definition in the genetic analysis of longitudinal phenotypes. We utilized data from ... -
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
(2014)Approaches exploiting extremes of the trait distribution may reveal novel loci for common traits, but it is unknown whether such loci are generalizable to the general population. In a genome-wide search for loci associated ... -
Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption
(Public Library of Science, 2011)We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted ... -
Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption
(Public Library of Science, 2011)We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted ... -
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
(Nature Publishing Group, 2016)Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe ... -
Genome-wide polygenic scoring for a 14-year long-term average depression phenotype
(Wiley Periodicals, Inc., 2014)Background: Despite moderate heritability estimates for depression-related phenotypes, few robust genetic predictors have been identified. Potential explanations for this discrepancy include the use of phenotypic measures ... -
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages
(National Academy of Sciences, 2005)Macrophages are central to host defense against microbes, but intracellular pathogens have evolved to evade their antimicrobial functions. Mycobacterium tuberculosis (MTB) has successfully exploited macrophages as its ... -
Genome-Wide RNAi Screen in \(IFN-\gamma-Treated\) Human Macrophages Identifies Genes Mediating Resistance to the Intracellular Pathogen Francisella tularensis
(Public Library of Science, 2012)Interferon-gamma \((IFN-\gamma)\) inhibits intracellular replication of Francisella tularensis in human monocyte-derived macrophages (HMDM) and in mice, but the mechanisms of this protective effect are poorly characterized. ... -
Genome-wide significant risk associations for mucinous ovarian carcinoma
(Nature Publishing Group, 2015)Genome-wide association studies have identified several risk associations for ovarian carcinomas but not for mucinous ovarian carcinomas (MOCs). Our analysis of 1,644 MOC cases and 21,693 controls with imputation identified ... -
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
(2016)The activities and genome-wide specificities of CRISPR-Cas Cpf1 nucleases1 are not well defined. We show that two Cpf1 nucleases from Acidaminococcus sp. BV3L6 and Lachnospiraceae bacterium ND2006 (AsCpf1 and LbCpf1, ... -
A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes
(Elsevier BV, 2014)Background: Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes ... -
A Genome-Wide “Pleiotropy Scan” Does Not Identify New Susceptibility Loci for Estrogen Receptor Negative Breast Cancer
(Public Library of Science, 2014)Approximately 15–30% of all breast cancer tumors are estrogen receptor negative (ER−). Compared with ER-positive (ER+) disease they have an earlier age at onset and worse prognosis. Despite the vast number of risk variants ... -
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma
(New England Journal of Medicine (NEJM/MMS), 2011)Background: The response to treatment for asthma is characterized by wide interindividual variability, with a significant number of patients who have no response. We hypothesized that a genomewide association study would ... -
Genomewide Association Study for Determinants of HIV-1 Acquisition and Viral Set Point in HIV-1 Serodiscordant Couples with Quantified Virus Exposure
(Public Library of Science (PLoS), 2011)BACKGROUND: Host genetic factors may be important determinants of HIV-1 sexual acquisition. We performed a genome-wide association study (GWAS) for host genetic variants modifying HIV-1 acquisition and viral control in the ...