Browsing SPH Scholarly Articles by Title

Now showing items 2783-2802 of 6362

    • Gut Microbiota Metabolites of Dietary Lignans and Risk of Type 2 Diabetes: A Prospective Investigation in Two Cohorts of U.S. Women 

      Sun, Qi; Wedick, Nicole; Pan, An; Townsend, Mary; Cassidy, Aedin; Franke, Adrian; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Hu, Frank; van Dam, Rob M. (American Diabetes Association, 2014)
      OBJECTIVE To examine urinary levels of enterolactone and enterodiol, intestinal microbial metabolites of dietary lignans, in relation to type 2 diabetes (T2D) risk. RESEARCH DESIGN AND METHODS Urinary concentrations of the ...

    • Gut-Microbiome-Related LCT Genotype and 2-Year Changes in Body Composition and Fat Distribution: The POUNDS Lost Trial 

      Heianza, Yoriko; Sun, Dianjianyi; Ma, Wenjie; Zheng, Yan; Champagne, Catherine M.; Bray, George A.; Sacks, Frank; Qi, Lu (Springer Science and Business Media LLC, 2018-02-26)
      Background/Objectives Gut microbiome regulates host energy metabolism and adiposity. A recent study identified a genome-wide significant variant in the lactase (LCT) gene that determines gut microbiome abundance. We ...

    • GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer 

      Pharoah, Paul D. P.; Tsai, Ya-Yu; Ramus, Susan J.; Phelan, Catherine M.; Goode, Ellen L.; Lawrenson, Kate; Price, Melissa; Fridley, Brooke L.; Tyrer, Jonathan P.; Shen, Howard; Weber, Rachel; Karevan, Rod; Larson, Melissa C.; Song, Honglin; Tessier, Daniel C.; Bacot, François; Vincent, Daniel; Cunningham, Julie M.; Dennis, Joe; Dicks, Ed; Aben, Katja K.; Anton-Culver, Hoda; Antonenkova, Natalia; Armasu, Sebastian M.; Baglietto, Laura; Bandera, Elisa V.; Beckmann, Matthias W.; Birrer, Michael J.; Bloom, Greg; Bogdanova, Natalia; Brenton, James D.; Brinton, Louise A.; Brooks-Wilson, Angela; Brown, Robert; Butzow, Ralf; Campbell, Ian; Carney, Michael E; Carvalho, Renato S.; Chang-Claude, Jenny; Chen, Y. Anne; Chen, Zhihua; Chow, Wong-Ho; Cicek, Mine S.; Coetzee, Gerhard; Cook, Linda S.; Cramer, Daniel W.; Cybulski, Cezary; Dansonka-Mieszkowska, Agnieszka; Despierre, Evelyn; Doherty, Jennifer A; Dörk, Thilo; du Bois, Andreas; Dürst, Matthias; Eccles, Diana; Edwards, Robert; Ekici, Arif B.; Fasching, Peter A.; Fenstermacher, David; Flanagan, James; Gao, Yu-Tang; Garcia-Closas, Montserrat; Gentry-Maharaj, Aleksandra; Giles, Graham; Gjyshi, Anxhela; Gore, Martin; Gronwald, Jacek; Guo, Qi; Halle, Mari K; Harter, Philipp; Hein, Alexander; Heitz, Florian; Hillemanns, Peter; Hoatlin, Maureen; Høgdall, Estrid; Høgdall, Claus K.; Hosono, Satoyo; Jakubowska, Anna; Jensen, Allan; Kalli, Kimberly R.; Karlan, Beth Y.; Kelemen, Linda E.; Kiemeney, Lambertus A.; Kjaer, Susanne Krüger; Konecny, Gottfried E.; Krakstad, Camilla; Kupryjanczyk, Jolanta; Lambrechts, Diether; Lambrechts, Sandrina; Le, Nhu D.; Lee, Nathan; Lee, Janet; Leminen, Arto; Lim, Boon Kiong; Lissowska, Jolanta; Lubiński, Jan; Lundvall, Lene; Lurie, Galina; Massuger, Leon F.A.G.; Matsuo, Keitaro; McGuire, Valerie; McLaughlin, John R; Menon, Usha; Modugno, Francesmary; Moysich, Kirsten B.; Nakanishi, Toru; Narod, Steven A.; Ness, Roberta B.; Nevanlinna, Heli; Nickels, Stefan; Noushmehr, Houtan; Odunsi, Kunle; Olson, Sara; Orlow, Irene; Paul, James; Pejovic, Tanja; Pelttari, Liisa M; Permuth-Wey, Jenny; Pike, Malcolm C; Poole, Elizabeth M; Qu, Xiaotao; Risch, Harvey A.; Rodriguez-Rodriguez, Lorna; Rossing, Mary Anne; Rudolph, Anja; Runnebaum, Ingo; Rzepecka, Iwona K; Salvesen, Helga B.; Schwaab, Ira; Severi, Gianluca; Shen, Hui; Shridhar, Vijayalakshmi; Shu, Xiao-Ou; Sieh, Weiva; Southey, Melissa C.; Spellman, Paul; Tajima, Kazuo; Teo, Soo-Hwang; Terry, Kathryn L.; Thompson, Pamela J; Timorek, Agnieszka; Tworoger, Shelley S.; van Altena, Anne M.; Berg, David Van Den; Vergote, Ignace; Vierkant, Robert A.; Vitonis, Allison F.; Wang-Gohrke, Shan; Wentzensen, Nicolas; Whittemore, Alice S.; Wik, Elisabeth; Winterhoff, Boris; Woo, Yin Ling; Wu, Anna H; Yang, Hannah P.; Zheng, Wei; Ziogas, Argyrios; Zulkifli, Famida; Goodman, Marc T.; Hall, Per; Easton, Douglas F; Pearce, Celeste L; Berchuck, Andrew; Chenevix-Trench, Georgia; Iversen, Edwin; Monteiro, Alvaro N.A.; Gayther, Simon A.; Schildkraut, Joellen M.; Sellers, Thomas A. (2013)
      Genome wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC) with another two loci being close to genome-wide significance. We pooled data from a GWAS conducted in ...

    • GWAS of Follicular Lymphoma Reveals Allelic Heterogeneity at 6p21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-Cell Lymphoma 

      Smedby, Karin E.; Foo, Jia Nee; Skibola, Christine F.; Darabi, Hatef; Conde, Lucia; Hjalgrim, Henrik; Kumar, Vikrant; Chang, Ellen T.; Rothman, Nathaniel; Cerhan, James R.; Brooks-Wilson, Angela R.; Rehnberg, Emil; Irwan, Ishak D.; Ryder, Lars P.; Bracci, Paige M.; Agana, Luz; Riby, Jacques; Cozen, Wendy; Hartge, Patricia; Morton, Lindsay M.; Severson, Richard K.; Slager, Susan L.; Fredericksen, Zachary S.; Novak, Anne J.; Kay, Neil E.; Habermann, Thomas M.; Armstrong, Bruce; Kricker, Anne; Milliken, Sam; Purdue, Mark P.; Vajdic, Claire M.; Boyle, Peter; Lan, Qing; Zahm, Shelia H.; Zhang, Yawei; Zheng, Tongzhang; Leach, Stephen; Spinelli, John J.; Smith, Martyn T.; Chanock, Stephen J.; Padyukov, Leonid; Alfredsson, Lars; Klareskog, Lars; Glimelius, Bengt; Melbye, Mads; Liu, Edison T.; Humphreys, Keith; Liu, Jianjun; Gibson, Greg; Brown, Peter N.; Davis, Scott; Wang, Sophia S.; Adami, Hans-Olov (Public Library of Science, 2011)
      Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 ...

    • The H1N1 pandemic: media frames, stigmatization and coping 

      McCauley, Michael; Minsky, Sara; Viswanath, Kasisomayajula (BioMed Central, 2013)
      Background: Throughout history, people have soothed their fear of disease outbreaks by searching for someone to blame. Such was the case with the April 2009 H1N1 flu outbreak. Mexicans and other Latinos living in the US ...

    • H1N1 vaccination and adults with underlying health conditions in the US 

      Goldstein, Edward; Lipsitch, Marc (Public Library of Science (PLoS), 2009)
      65% of fatalities from pH1N1 infections in a large US case series occur in adults with underlying health conditions other than pregnancy, but it appears that only relatively few high-risk adults will get vaccinated during ...

    • Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men12 

      Cassidy, Aedín; Bertoia, Monica; Chiuve, Stephanie; Flint, Alan; Forman, John; Rimm, Eric B (American Society for Nutrition, 2016)
      Background: Although increased fruit intake reduces cardiovascular disease (CVD) risk, which fruits are most beneficial and what key constituents are responsible are unclear. Habitual intakes of flavonoids, specifically ...

    • Habitual intake of dietary flavonoids and risk of Parkinson disease 

      Gao, X.; Cassidy, A.; Schwarzschild, M. A.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Ascherio, A. (2012)
      Objective: To prospectively examine whether higher intakes of total flavonoids and their subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, and polymers) were associated with a lower risk of developing ...

    • Habitual intake of flavonoid subclasses and incident hypertension in adults 

      Cassidy, Aedín; O'Reilly, Éilis J.; Kay, Colin; Sampson, Laura; Franz, Mary; Forman, J. P.; Curhan, Gary; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 (Oxford University Press, 2011)
      Background: Dietary flavonoids have beneficial effects on blood pressure in intervention settings, but there is limited information on habitual intake and risk of hypertension in population-based studies. Objective: We ...

    • Habitual intake of flavonoid subclasses and risk of colorectal cancer in 2 large prospective cohorts12 

      Nimptsch, Katharina; Zhang, Xuehong; Cassidy, Aedín; Song, Mingyang; O’Reilly, Éilis J; Lin, Jennifer H; Pischon, Tobias; Rimm, Eric B; Willett, Walter C; Fuchs, Charles S; Ogino, Shuji; Chan, Andrew T; Giovannucci, Edward L; Wu, Kana (American Society for Nutrition, 2016)
      Background: Flavonoids inhibit the growth of colon cancer cells in vitro. In a secondary analysis of a randomized controlled trial, the Polyp Prevention Trial, a higher intake of one subclass, flavonols, was statistically ...

    • Haematological Safety of Perinatal Zidovudine in Pregnant HIV-1–Infected Women in Thailand: Secondary Analysis of a Randomized Trial 

      Briand, Nelly; Lallemant, Marc Jean; Jourdain, Gonzague Joseph Albert; Techapalokul, Somnuek; Tunthanathip, Preecha; Suphanich, Surachet; Chanpoo, Truengta; Traisathit, Patrinee; McIntosh, Kenneth; Coeur, Sophie Le (Public Library of Science, 2007)
      Objectives: To respond to the primary safety objective of the Perinatal HIV Prevention Trial 1 (PHPT-1) by studying the evolution of haematological parameters according to zidovudine exposure duration in HIV-1−infected ...

    • Hair Manganese and Hyperactive Behaviors: Pilot Study of School-Age Children Exposed through Tap Water 

      Bouchard, Maryse; Laforest, François; Vandelac, Louise; Bellinger, David C.; Mergler, Donna (National Institute of Environmental Health Sciences, 2006)
      Background: Neurotoxic effects are known to occur with inhalation of manganese particulates, but very few data are available on exposure to Mn in water. We undertook a pilot study in a community in Québec (Canada) where ...

    • Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation 

      Tomasetti, Cristian; Vogelstein, Bert; Parmigiani, Giovanni (National Academy of Sciences, 2013)
      Although it has been hypothesized that some of the somatic mutations found in tumors may occur before tumor initiation, there is little experimental or conceptual data on this topic. To gain insights into this fundamental ...

    • Hallux valgus and plantar pressure loading: the Framingham foot study 

      Galica, Andrew M; Hagedorn, Thomas J; Dufour, Alyssa B; Riskowski, Jody L; Hillstrom, Howard J; Casey, Virginia A; Hannan, Marian T (BioMed Central, 2013)
      Background: Hallux valgus (HV), a common structural foot deformity, can cause foot pain and lead to limited mobility. The purpose of this study was to evaluate differences in plantar pressure and force during gait by HV ...

    • Halo effect of a weight-loss trial on spouses: the DIRECT-Spouse study 

      Golan, Rachel; Schwarzfuchs, Dan; Stampfer, Meir; Shai, Iris (Cambridge University Press, 2010)
      Objective: We examined the halo effect of a 2-year weight-loss diet trial, the Dietary Intervention Randomized Controlled Trial (DIRECT), on the weight and nutritional patterns of participants' spouses. Design: DIRECT ...

    • Handling random errors and biases in methods used for short-term dietary assessment 

      Rossato, Sinara L; Fuchs, Sandra C (Faculdade de Saúde Pública da Universidade de São Paulo, 2014)
      Epidemiological studies have shown the effect of diet on the incidence of chronic diseases; however, proper planning, designing, and statistical modeling are necessary to obtain precise and accurate food consumption data. ...

    • Handling the data management needs of high-throughput sequencing data: SpeedGene, a compression algorithm for the efficient storage of genetic data 

      Qiao, Dandi; Yip, Wai-Ki; Lange, Christoph (BioMed Central, 2012)
      Background: As Next-Generation Sequencing data becomes available, existing hardware environments do not provide sufficient storage space and computational power to store and process the data due to their enormous size. ...

    • Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring 

      Lao, Taotao; Glass, Kimberly; Qiu, Weiliang; Polverino, Francesca; Gupta, Kushagra; Morrow, Jarrett; Mancini, John Dominic; Vuong, Linh; Perrella, Mark A; Hersh, Craig P; Owen, Caroline A; Quackenbush, John; Yuan, Guo-Cheng; Silverman, Edwin K; Zhou, Xiaobo (BioMed Central, 2015)
      Background: The HHIP gene, encoding Hedgehog interacting protein, has been implicated in chronic obstructive pulmonary disease (COPD) by genome-wide association studies (GWAS), and our subsequent studies identified a ...

    • Haplotype Block Partitioning and Tag SNP Selection Using Genotype Data and Their Applications to Association Studies 

      Zhang, Kui; Qin, Zhaohui S.; Liu, Jun; Chen, Ting; Waterman, Michael S.; Sun, Fengzhu (Cold Spring Harbor Laboratory Press, 2004)
      Recent studies have revealed that linkage disequilibrium (LD) patterns vary across the human genome with some regions of high LD interspersed by regions of low LD. A small fraction of SNPs (tag SNPs) is sufficient to capture ...

    • Haplotype Information and Linkage Disequilibrium Mapping for Single Nucleotide Polymorphisms 

      Lu, Xin; Niu, Tianhua; Liu, Jun (Cold Spring Harbor Laboratory Press, 2003)
      Single nucleotide polymorphisms in the human genome have become an increasingly popular topic in that their analyses promise to be a key step toward personalized medicine. We investigate two related questions, how much the ...