Browsing SPH Scholarly Articles by Title

Now showing items 4109-4128 of 6362

    • NEST 2014: Views from the Trainees—Talking About What Matters in Efforts to Diversify the STEM Workforce 

      Campbell, Andrew G.; Skvirsky, Rachel; Wortis, Henry; Thomas, Sheila; Kawachi, Ichiro; Hohmann, Christine (American Society for Cell Biology, 2014)
      This paper summarizes the outcomes of a retreat designed to cultivate interactions between trainees at various training levels and provide them opportunities to share their training perspectives and expectations. Retreat ...

    • A Nested Case–Control Study of Metabolically Defined Body Size Phenotypes and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) 

      Murphy, Neil; Cross, Amanda J.; Abubakar, Mustapha; Jenab, Mazda; Aleksandrova, Krasimira; Boutron-Ruault, Marie-Christine; Dossus, Laure; Racine, Antoine; Kühn, Tilman; Katzke, Verena A.; Tjønneland, Anne; Petersen, Kristina E. N.; Overvad, Kim; Quirós, J. Ramón; Jakszyn, Paula; Molina-Montes, Esther; Dorronsoro, Miren; Huerta, José-María; Barricarte, Aurelio; Khaw, Kay-Tee; Wareham, Nick; Travis, Ruth C.; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Masala, Giovanna; Krogh, Vittorio; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Siersema, Peter D.; Peeters, Petra H.; Ohlsson, Bodil; Ericson, Ulrika; Palmqvist, Richard; Nyström, Hanna; Weiderpass, Elisabete; Skeie, Guri; Freisling, Heinz; Kong, So Yeon; Tsilidis, Kostas; Muller, David C.; Riboli, Elio; Gunter, Marc J (Public Library of Science, 2016)
      Background: Obesity is positively associated with colorectal cancer. Recently, body size subtypes categorised by the prevalence of hyperinsulinaemia have been defined, and metabolically healthy overweight/obese individuals ...

    • Network analysis of gene essentiality in functional genomics experiments 

      Jiang, Peng; Wang, Hongfang; Li, Wei; Zang, Chongzhi; Li, Bo; Wong, Yinling J.; Meyer, Cliff; Liu, Jun S.; Aster, Jon C.; Liu, X. Shirley (BioMed Central, 2015)
      Many genomic techniques have been developed to study gene essentiality genome-wide, such as CRISPR and shRNA screens. Our analyses of public CRISPR screens suggest protein interaction networks, when integrated with gene ...

    • A Network Approach to Analyzing Highly Recombinant Malaria Parasite Genes 

      Larremore, Daniel B.; Clauset, Aaron; Buckee, Caroline O. (Public Library of Science, 2013)
      The var genes of the human malaria parasite Plasmodium falciparum present a challenge to population geneticists due to their extreme diversity, which is generated by high rates of recombination. These genes encode a primary ...

    • A network model for angiogenesis in ovarian cancer 

      Glass, Kimberly; Quackenbush, John; Spentzos, Dimitrios; Haibe-Kains, Benjamin; Yuan, Guo-Cheng (BioMed Central, 2015)
      Background: We recently identified two robust ovarian cancer subtypes, defined by the expression of genes involved in angiogenesis, with significant differences in clinical outcome. To identify potential regulatory mechanisms ...

    • A Network of Epigenetic Regulators Guide Developmental Hematopoiesis In Vivo 

      Huang, Hsuan-Ting; Kathrein, Katie L.; Barton, Abby; Gitlin, Zachary; Huang, Yue-Hua; Ward, Thomas P.; Hofmann, Oliver; Dibiase, Anthony; Song, Anhua; Tyekucheva, Svitlana; Hide, Winston; Zhou, Yi; Zon, Leonard I. (2013)
      The initiation of cellular programs is orchestrated by key transcription factors and chromatin regulators that activate or inhibit target gene expression. To generate a compendium of chromatin factors that establish the ...

    • Network-based social capital and capacity-building programs: an example from Ethiopia 

      Ramanadhan, Shoba; Kebede, Sosena; Mantopoulos, Jeannie; Bradley, Elizabeth (Springer Nature, 2010)
      Introduction Capacity-building programs are vital for healthcare workforce development in low- and middle-income countries. In addition to increasing human capital, participation in such programs may lead to new professional ...

    • Network-Level Structural Abnormalities of Cerebral Cortex in Type 1 Diabetes Mellitus 

      Lyoo, In Kyoon; Yoon, Sujung; Renshaw, Perry F.; Hwang, Jaeuk; Bae, Sujin; Musen, Gail; Kim, Jieun E.; Bolo, Nicolas; Jeong, Hyeonseok S.; Simonson, Donald C.; Lee, Sun Hea; Weinger, Katie; Jung, Jiyoung J.; Ryan, Christopher M.; Choi, Yera; Jacobson, Alan M. (Public Library of Science, 2013)
      Type 1 diabetes mellitus (T1DM) usually begins in childhood and adolescence and causes lifelong damage to several major organs including the brain. Despite increasing evidence of T1DM-induced structural deficits in cortical ...

    • Neural stem cells respond to stress hormones: distinguishing beneficial from detrimental stress 

      Koutmani, Yassemi; Karalis, Katia P. (Frontiers Media S.A., 2015)
      Neural stem cells (NSCs), the progenitors of the nervous system, control distinct, position-specific functions and are critically involved in the maintenance of homeostasis in the brain. The responses of these cells to ...

    • Neurobehavioral and neurodevelopmental effects of pesticide exposures 

      London, Leslie; Beseler, Cheryl; Bouchard, Maryse F.; Bellinger, David C.; Colosio, Claudio; Grandjean, Philippe; Harari, Raul; Kootbodien, Tahira; Kromhout, Hans; Little, Francesca; Meijster, Tim; Moretto, Angelo; Rohlman, Diane S.; Stallones, Lorann (Elsevier BV, 2012)
      The association between pesticide exposure and neurobehavioral and neurodevelopmental effects is an area of increasing concern. This symposium brought together participants to explore the neurotoxic effects of pesticides ...

    • Neurobehavioral Deficits and Increased Blood Pressure in School-Age Children Prenatally Exposed to Pesticides 

      Harari, Raul; Julvez, Jordi; Murata, Katsuyuki; Barr, Dana; Bellinger, David C.; Debes, Frodi; Grandjean, Philippe (National Institute of Environmental Health Sciences, 2010)
      Background: The long-term neurotoxicity risks caused by prenatal exposures to pesticides are unclear, but a previous pilot study of Ecuadorian school children suggested that blood pressure and visuospatial processing may ...

    • Neurobehavioral deficits at age 7years associated with prenatal exposure to toxicants from maternal seafood diet 

      Grandjean, Philippe; Weihe, Pal; Nielsen, Flemming; Heinzow, Birger; Debes, Frodi; Budtz-Jørgensen, Esben (Elsevier BV, 2012)
      To determine the possible neurotoxic impact of prenatal exposure to polychlorinated biphenyls (PCBs), we analyzed banked cord blood from a Faroese birth cohort for PCBs. The subjects were born in 1986–1987, and 917 cohort ...

    • Neurobehavioral Deficits, Diseases, and Associated Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union 

      Bellanger, Martine; Demeneix, Barbara; Grandjean, Philippe; Zoeller, R. Thomas; Trasande, Leonardo (The Endocrine Society, 2015)
      Context: Epidemiological studies and animal models demonstrate that endocrine disrupting chemicals (EDCs) contribute to cognitive deficits and neurodevelopmental disabilities.Objective: To estimate neurodevelopmental ...

    • Neurobehavioral epidemiology: application in risk assessment 

      Grandjean, Philippe; White, RF; Weihe, Pal (National Institute of Environmental Health Sciences, 1996)
      Neurobehavioral epidemiology may contribute information to risk assessment in relation to a) characterization of neurotoxicity and its time course; b) the dose-effect relationship; c) the dose-response relationship; and ...

    • Neurobehavioral Function in School-Age Children Exposed to Manganese in Drinking Water 

      Oulhote, Youssef; Mergler, Donna; Barbeau, Benoit; Bellinger, David C.; Bouffard, Thérèse; Brodeur, Marie-Ève; Saint-Amour, Dave; Legrand, Melissa; Sauvé, Sébastien; Bouchard, Maryse F. (NLM-Export, 2014)
      Background: Manganese neurotoxicity is well documented in individuals occupationally exposed to airborne particulates, but few data are available on risks from drinking-water exposure. Objective: We examined associations ...

    • Neurobehavioral performance of Inuit children with increased prenatal exposure to methylmercury 

      Weihe, Pal; Hansen, Jens C.; Murata, Katsuyuki; Debes, Frodi; Jorgensen, Poul J.; Steuerwald, Ulrike; White, Roberta F; Grandjean, Philippe (Taylor & Francis Open, 2002)
      Exposure to methylmercury from marine mammals and other seafood may affect the development of the central nervous system. In a traditional Inuit community in Qaanaaq, Greenland, mercury concentrations in cord blood and ...

    • Neurobehavioural effects of developmental toxicity 

      Grandjean, Philippe; Landrigan, Philip J. (Elsevier BV, 2014)
      Neurodevelopmental disabilities, including autism, attention-deficit hyperactivity disorder, dyslexia, and other cognitive impairments, affect millions of children worldwide, and some diagnoses seem to be increasing in ...

    • Neurodevelopmental outcome at two years of age after general and awake-regional anaesthesia in infancy: a randomised controlled trial 

      Davidson, Andrew J.; Disma, Nicola; de Graaff, Jurgen C.; Withington, Davinia E.; Dorris, Liam; Bell, Graham; Stargatt, Robyn; Bellinger, David C.; Schuster, Tibor; Arnup, Sarah J.; Hardy, Pollyanna; Hunt, Rodney W.; Takagi, Michael J.; Giribaldi, Gaia; Hartmann, Penelope L.; Salvo, Ida; Morton, Neil S.; von Ungern Sternberg, Britta S; Locatelli, Bruno Guido; Wilton, Niall; Lynn, Anne; Thomas, Joss J.; Polaner, David; Bagshaw, Oliver; Szmuk, Peter; Absalom, Anthony R.; Frawley, Geoff; Berde, Charles; Ormond, Gillian D; Marmor, Jacki; Ellen, Mary (2016)
      Summary Background: There is pre-clinical evidence that general anaesthetics affect brain development. There is mixed evidence from cohort studies that young children exposed to anaesthesia may have an increased risk of ...

    • Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water 

      Rodrigues, Ema G.; Bellinger, David C.; Valeri, Linda; Hasan, Md Omar Sharif Ibne; Quamruzzaman, Quazi; Golam, Mostofa; Kile, Molly L.; Christiani, David C.; Wright, Robert O.; Mazumdar, Maitreyi (BioMed Central, 2016)
      Background: The people of Bangladesh are currently exposed to high concentrations of arsenic and manganese in drinking water, as well as elevated lead in many regions. The objective of this study was to investigate ...

    • Neurological and neuropsychological functions in adults with a history of developmental arsenic poisoning from contaminated milk powder 

      Yorifuji, Takashi; Kato, Tsuguhiko; Ohta, Hitoshi; Bellinger, David C; Matsuoka, Kenichi; Grandjean, Philippe (Elsevier BV, 2016)
      During the summer of 1955, mass arsenic poisoning of bottle-fed infants occurred in the western part of Japan due to contaminated milk powder, and more than 100 died; some childhood victims were later found to suffer from ...