Now showing items 21-40 of 6362

    • Viral dynamics and duration of PCR positivity of the SARS-CoV-2 Omicron variant 

      Hay, James; Kissler, Stephen; Fauver, Joseph R.; Mack, Christina; Tai, Caroline G.; Samant, Radhika M.; Connelly, Sarah; Anderson, Deverick J.; Khullar, Gaurav; MacKay, Matthew; Patel, Miral; Kelly, Shannan; Manhertz, April; Eiter, Isaac; Salgado, Daisy; Baker, Tim; Dudley, Joel T.; Mason, Christopher E.; Ho, David D.; Grubaugh, Nathan D.; Grad, Yonatan (2022)
      Background: The Omicron SARS-CoV-2 variant is responsible for a major wave of COVID-19, with record case counts reflecting high transmissibility and escape from prior immunity. Defining the time course of Omicron viral ...
    • A hormone complex of FABP4 and nucleoside kinases regulates islet function 

      Prentice, Kacey J.; Saksi, Jani Pertti Kristian; Robertson, Lauren T.; Lee, Grace Y.; Inouye, Karen; Eguchi, Kosei; Lee, Alexandra; Cakici, Ozgur; Otterbeck, Emily; Cedillo, Paulina; Achenbach, Peter; Ziegler, Anette-Gabriele; Calay, Ediz; Engin, Feyza; Hotamisligil, Gökhan S.; Hotamisligil, Gokhan (Springer Science and Business Media LLC, 2021-12-08)
      Liberation of energy stores from adipocytes is critical to support survival in times of energy deficit, however, uncontrolled or chronic lipolysis associated with insulin resistance and/or insulin insufficiency, disrupts ...
    • Anemia Etiology in Ethiopia: Assessment of Nutritional, Infectious Disease, and Other Risk Factors in a Population-based Cross-sectional Survey of Women, Men, and Children 

      Andersen, Christopher; Tadesse, Amare; Bromage, Sabri; Fekadu, Habtamu; Hemler, Elena; Passarelli, Simone; Spiegelman, Donna; Sudfeld, Christopher; Worku, Alemayehu; Berhane, Yemane; Fawzi, Wafaie (Oxford University Press (OUP), 2021-10-14)
      Background: While the causes of anemia at an individual level (such as certain nutritional deficiencies, infections, and genetic disorders) are well defined, there is limited understanding of the relative burden of anemia ...
    • Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data 

      Zhang, Jinye; Hou, Kangcheng; Dey, Kushal; Sakaue, Saori; Jagadeesh, Karthik; Weinand, Kathryn; Taychameekiatchai, Aris; Rao, Poorvi; Pisco, Angela; Zou, James; Wang, Bruce; Gandal, Michael; Raychaudhuri, Soumya; Pasaniuc, Bogdan; Price, Alkes (Research Square Platform LLC, 2021-10-05)
      Gene expression at the individual cell-level resolution, as quantified by single-cell RNA-sequencing (scRNA-seq), can provide unique insights into the pathology and cellular origin of diseases and complex traits. Here, we ...
    • When Disaster Management Agencies Create Disaster Risk: A Case Study of the US's Federal Emergency Management Agency 

      Clark-Ginsberg, Aaron; Easton-Calabria, Lena C.; Patel, Sonny; Balagna, Jay; Payne, Leslie A. (Emerald, 2021-09-28)
      Purpose – Disaster management agencies are mandated to reduce risk for the populations that they serve. Yet, inequities in how they function may result in their activities creating disaster risk, particularly for already ...
    • A finding of sex similarities rather than differences in COVID-19 outcomes 

      Shattuck-Heidorn, Heather; Danielsen, Ann Caroline; Gompers, Annika; Bruch, Joseph Dov; Zhao, Helen; Boulicault, Marion; Marsella, Jamie; Richardson, Sarah S. (Springer Science and Business Media LLC, 2021-09-22)
      The sex disparity in COVID-19 mortality varies widely and is of uncertain origin. In their recent Nature paper “Sex differences in immune responses that underlie COVID-19 disease outcomes," Takahashi et al. assess immune ...
    • Aquatic foods to nourish nations 

      Golden, Christopher; Koehn, J. Zachary; Shepon, Alon; Passarelli, Simone; Free, Christopher M.; Viana, Daniel; Matthey, Holger; Eurich, Jacob G.; Gephart, Jessica A.; Fluet-Chouinard, Etienne; Nyboer, Elizabeth A.; Lynch, Abigail J.; Kjellevold, Marian; Bromage, Sabri; Charlebois, Pierre; Barange, Manuel; Vannuccini, Stefania; Cao, Ling; Kleisner, Kristin M.; Rimm, Eric B.; Danaei, Goodarz; DeSisto, Camille; Kelahan, Heather; Fiorella, Kathryn J.; Little, David C.; Allison, Edward H.; Fanzo, Jessica; Thilsted, Shakuntala H. (Springer Science and Business Media LLC, 2021-09-15)
      Despite contributing to healthy diets for billions of people, aquatic foods are often undervalued as a nutritional solution because their diversity is often reduced to the protein and energy value of a single food type ...
    • Harnessing the diversity of small-scale actors is key to the future of aquatic food systems 

      Short, Rebecca E.; Gelcich, Stefan; Little, David C.; Micheli, Fiorenza; Allison, Edward H.; Basurto, Xavier; Belton, Ben; Brugere, Cecile; Bush, Simon R.; Cao, Ling; Crona, Beatrice; Cohen, Philippa J.; Defeo, Omar; Edwards, Peter; Ferguson, Caroline E.; Franz, Nicole; Golden, Christopher; Halpern, Benjamin S.; Hazen, Lucie; Hicks, Christina; Johnson, Derek; Kaminski, Alexander M.; Mangubhai, Sangeeta; Naylor, Rosamond L.; Reantaso, Melba; Sumaila, U. Rashid; Thilsted, Shakuntala H.; Tigchelaar, Michelle; Wabnitz, Colette C. C.; Zhang, Wenbo (Springer Science and Business Media LLC, 2021-09-15)
    • Compound climate risks threaten aquatic food system benefits 

      Tigchelaar, Michelle; Cheung, William W. L.; Mohammed, Essam Yassin; Phillips, Michael J.; Payne, Hanna J.; Selig, Elizabeth R.; Wabnitz, Colette C. C.; Oyinlola, Muhammed A.; Frölicher, Thomas L.; Gephart, Jessica A.; Golden, Christopher D.; Allison, Edward H.; Bennett, Abigail; Cao, Ling; Fanzo, Jessica; Halpern, Benjamin S.; Lam, Vicky W. Y.; Micheli, Fiorenza; Naylor, Rosamond L.; Sumaila, U. Rashid; Tagliabue, Alessandro; Troell, Max (Springer Science and Business Media LLC, 2021-09-15)
    • Federated learning for predicting clinical outcomes in patients with COVID-19 

      Dayan, Ittai; Roth, Holger R.; Zhong, Aoxiao; Harouni, Ahmed; Gentili, Amilcare; Abidin, Anas Z.; Liu, Andrew; Costa, Anthony Beardsworth; Wood, Bradford J.; Tsai, Chien-Sung; Wang, Chih-Hung; Hsu, Chun-Nan; Lee, C. K.; Ruan, Peiying; Xu, Daguang; Wu, Dufan; Huang, Eddie; Kitamura, Felipe Campos; Lacey, Griffin; de Antônio Corradi, Gustavo César; Nino, Gustavo; Shin, Hao-Hsin; Obinata, Hirofumi; Ren, Hui; Crane, Jason C.; Tetreault, Jesse; Guan, Jiahui; Garrett, John W.; Kaggie, Joshua D.; Park, Jung Gil; Dreyer, Keith; Juluru, Krishna; Kersten, Kristopher; Rockenbach, Marcio Aloisio Bezerra Cavalcanti; Linguraru, Marius George; Haider, Masoom A.; AbdelMaseeh, Meena; Rieke, Nicola; Damasceno, Pablo F.; e Silva, Pedro Mario Cruz; Wang, Pochuan; Xu, Sheng; Kawano, Shuichi; Sriswasdi, Sira; Park, Soo Young; Grist, Thomas M.; Buch, Varun; Jantarabenjakul, Watsamon; Wang, Weichung; Tak, Won Young; Li, Xiang; Lin, Xihong; Kwon, Young Joon; Quraini, Abood; Feng, Andrew; Priest, Andrew N.; Turkbey, Baris; Glicksberg, Benjamin; Bizzo, Bernardo; Kim, Byung Seok; Tor-Díez, Carlos; Lee, Chia-Cheng; Hsu, Chia-Jung; Lin, Chin; Lai, Chiu-Ling; Hess, Christopher P.; Compas, Colin; Bhatia, Deepeksha; Oermann, Eric K.; Leibovitz, Evan; Sasaki, Hisashi; Mori, Hitoshi; Yang, Isaac; Sohn, Jae Ho; Murthy, Krishna Nand Keshava; Fu, Li-Chen; de Mendonça, Matheus Ribeiro Furtado; Fralick, Mike; Kang, Min Kyu; Adil, Mohammad; Gangai, Natalie; Vateekul, Peerapon; Elnajjar, Pierre; Hickman, Sarah; Majumdar, Sharmila; McLeod, Shelley L.; Reed, Sheridan; Gräf, Stefan; Harmon, Stephanie; Kodama, Tatsuya; Puthanakit, Thanyawee; Mazzulli, Tony; de Lavor, Vitor Lima; Rakvongthai, Yothin; Lee, Yu Rim; Wen, Yuhong; Gilbert, Fiona J.; Flores, Mona G.; Li, Quanzheng (Springer Science and Business Media LLC, 2021-09-15)
    • Effectiveness of the BNT162b2 mRNA COVID-19 Vaccine in Pregnancy 

      Dagan, Noa; Barda, Noam; Biron-Shental, Tal; Makov-Assif, Maya; Key, Calanit; Kohane, Isaac; Hernán, Miguel A.; Lipsitch, Marc; Hernandez-Diaz, Sonia; Reis, Ben; Balicer, Ran D. (Nature, 2021-09-07)
      To evaluate the effectiveness of the BNT162b2 mRNA vaccine among pregnant women, we conducted an observational cohort study of pregnant women 16 years or older, with no history of SARS-CoV-2, who were vaccinated between ...
    • Rethinking Malaria in the Context to COVID-19 

      Unknown author (The Defeating Malaria Initiative, 2021-09)
    • Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation 

      Min, Josine L.; Hemani, Gibran; Hannon, Eilis; Dekkers, Koen F.; Castillo-Fernandez, Juan; Luijk, René; Carnero-Montoro, Elena; Lawson, Daniel J.; Burrows, Kimberley; Suderman, Matthew; Bretherick, Andrew D.; Richardson, Tom G.; Klughammer, Johanna; Iotchkova, Valentina; Sharp, Gemma; Al Khleifat, Ahmad; Shatunov, Aleksey; Iacoangeli, Alfredo; McArdle, Wendy L.; Ho, Karen M.; Kumar, Ashish; Söderhäll, Cilla; Soriano-Tárraga, Carolina; Giralt-Steinhauer, Eva; Kazmi, Nabila; Mason, Dan; McRae, Allan F.; Corcoran, David L.; Sugden, Karen; Kasela, Silva; Cardona, Alexia; Day, Felix R.; Cugliari, Giovanni; Viberti, Clara; Guarrera, Simonetta; Lerro, Michael; Gupta, Richa; Bollepalli, Sailalitha; Mandaviya, Pooja; Zeng, Yanni; Clarke, Toni-Kim; Walker, Rosie M.; Schmoll, Vanessa; Czamara, Darina; Ruiz-Arenas, Carlos; Rezwan, Faisal I.; Marioni, Riccardo E.; Lin, Tian; Awaloff, Yvonne; Germain, Marine; Aïssi, Dylan; Zwamborn, Ramona; van Eijk, Kristel; Dekker, Annelot; van Dongen, Jenny; Hottenga, Jouke-Jan; Willemsen, Gonneke; Xu, Cheng-Jian; Barturen, Guillermo; Català-Moll, Francesc; Kerick, Martin; Wang, Carol; Melton, Phillip; Elliott, Hannah R.; Shin, Jean; Bernard, Manon; Yet, Idil; Smart, Melissa; Gorrie-Stone, Tyler; Shaw, Chris; Al Chalabi, Ammar; Ring, Susan M.; Pershagen, Göran; Melén, Erik; Jiménez-Conde, Jordi; Roquer, Jaume; Lawlor, Deborah A.; Wright, John; Martin, Nicholas G.; Montgomery, Grant W.; Moffitt, Terrie E.; Poulton, Richie; Esko, Tõnu; Milani, Lili; Metspalu, Andres; Perry, John R. B.; Ong, Ken K.; Wareham, Nicholas J.; Matullo, Giuseppe; Sacerdote, Carlotta; Panico, Salvatore; Caspi, Avshalom; Arseneault, Louise; Gagnon, France; Ollikainen, Miina; Kaprio, Jaakko; Felix, Janine F.; Rivadeneira, Fernando; Tiemeier, Henning; van IJzendoorn, Marinus H.; Uitterlinden, André G.; Jaddoe, Vincent W. V.; Haley, Chris; McIntosh, Andrew M.; Evans, Kathryn L.; Murray, Alison; Räikkönen, Katri; Lahti, Jari; Nohr, Ellen A.; Sørensen, Thorkild I. A.; Hansen, Torben; Morgen, Camilla S.; Binder, Elisabeth B.; Lucae, Susanne; Gonzalez, Juan Ramon; Bustamante, Mariona; Sunyer, Jordi; Holloway, John W.; Karmaus, Wilfried; Zhang, Hongmei; Deary, Ian J.; Wray, Naomi R.; Starr, John M.; Beekman, Marian; van Heemst, Diana; Slagboom, P. Eline; Morange, Pierre-Emmanuel; Trégouët, David-Alexandre; Veldink, Jan H.; Davies, Gareth E.; de Geus, Eco J. C.; Boomsma, Dorret I.; Vonk, Judith M.; Brunekreef, Bert; Koppelman, Gerard H.; Alarcón-Riquelme, Marta E.; Huang, Rae-Chi; Pennell, Craig E.; van Meurs, Joyce; Ikram, M. Arfan; Hughes, Alun D.; Tillin, Therese; Chaturvedi, Nish; Pausova, Zdenka; Paus, Tomas; Spector, Timothy D.; Kumari, Meena; Schalkwyk, Leonard C.; Visscher, Peter M.; Davey Smith, George; Bock, Christoph; Gaunt, Tom R.; Bell, Jordana T.; Heijmans, Bastiaan T.; Mill, Jonathan; Relton, Caroline L. (Springer Science and Business Media LLC, 2021-09)
      Characterising genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. Here we describe results of DNA methylation-quantitative trait loci ...
    • Augmenting and Directing Robust, Long-Range CRISPR-Mediated Activation in Human Cells 

      Tak, Y. Esther; Horng, Joy E.; Perry, Nicholas T.; Schultz, Hayley; Iyer, Sowmya; Yao, Qiuming; Zou, Luli S.; Aryee, Martin; Pinello, Luca; Joung, Keith (Springer Science and Business Media LLC, 2021-08-05)
      Epigenetic editing is an emerging technology that uses artificial transcription factors (aTFs) to regulate expression of a target gene. Although human genes can be robustly upregulated by targeting aTFs to promoters, the ...
    • Genetic Insights Into Biological Mechanisms Governing Human Ovarian Ageing 

      Ruth, Katherine S.; Day, Felix R.; Hussain, Jazib; Martínez-Marchal, Ana; Aiken, Catherine E.; Azad, Ajuna; Thompson, Deborah J.; Knoblochova, Lucie; Abe, Hironori; Tarry-Adkins, Jane L.; Martin-Gonzalez, Javier; Fontanillas, Pierre; Claringbould, Annique; Bakker, Olivier B.; Sulem, Patrick; Walters, Robin G.; Terao, Chikashi; Turon, Sandra; Horikoshi, Momoko; Lin, Kuang; Onland-Moret, N. Charlotte; Sankar, Aditya; Hertz, Emil Peter Thrane; Timshel, Pascal N.; Perry, John R.B. (Ovid Technologies (Wolters Kluwer Health), 2021-08-04)
      Reproductive longevity is critical for fertility and impacts healthy ageing in women, yet insights into the underlying biological mechanisms and treatments to preserve it are limited. Here, we identify 290 genetic determinants ...
    • Abstract 129: An integrated multi-omic cellular atlas of human breast cancers 

      Wu, Sunny Z.; Al-Eryani, Ghamdan; Roden, Daniel; Junankar, Simon; Harvey, Kate; Andersson, Alma; Thennavan, Aatish; Wang, Chenfei; Torpy, James; Bartonicek, Nenad; Wang, Taopeng; Larsson, Ludvig; Kaczorowski, Dominik; Weisenfeld, Neil I.; Uytingco, Cedric R.; Chew, Jennifer G.; Bent, Zachary W.; Chan, Chia-Ling; Gnanasambandapillai, Vikkitharan; Dutertre, Charles-Antoine; Gluch, Laurence; Hui, Mun N.; Beith, Jane; Parker, Andrew; Robbins, Elizabeth; Segara, Davendra; Mak, Cindy; Cooper, Caroline; Chan, Belinda; Warrier, Sanjay; Ginhoux, Florent; Millar, Ewan; Powell, Joseph E.; Williams, Stephen R.; Liu, X. Shirley; O'Toole, Sandra; Lim, Elgene; Lundeberg, Joakim; Perou, Charles M.; Swarbrick, Alexander (American Association for Cancer Research (AACR), 2021-07-01)
      Breast cancers are complex cellular ecosystems where heterotypic interactions play central roles in disease progression and response to therapy. However, our knowledge of the cellular composition and organization of breast ...
    • Rebooting consent in the digital age: a governance framework for health data exchange 

      Saksena, Nivedita; Matthan, Rahul; Bhan, Anant; Balsari, Satchit (BMJ, 2021-07)
      In August 2020, India announced its vision for the National Digital Health Mission (NDHM), a federated national digital health exchange where digitised data generated by healthcare providers will be exported via Application ...
    • Reduction in life expectancy in Brazil after COVID-19 

      Castro, Marcia; Gurzenda, Susan; Turra, Cassio M.; Kim, Sun; Andrasfay, Theresa; Goldman, Noreen; Goldman (Springer Science and Business Media LLC, 2021-06-29)
      Brazil has been heavily impacted by COVID-19. We use data on reported total deaths in 2020 and in Jan-Apr 2021 to measure and compare the death toll across states. We estimate a decline in 2020 life expectancy at birth ...
    • TRUST4: Immune Repertoire Reconstruction From Bulk and Single-Cell RNA-Seq Data 

      Song, Li; Cohen, David; Ouyang, Zhangyi; Cao, Yang; Hu, Xihao; Liu, Xiaole (Springer Science and Business Media LLC, 2021-06)
      We introduce the TRUST4 open-source algorithm for reconstruction of immune receptor repertoires in αβ/γδ T cells and B cells from RNA-sequencing (RNA-seq) data. Compared with competing methods, TRUST4 supports both FASTQ ...
    • Measuring the Scope of Prior Authorization Policies: Applying Private Insurer Rules to Medicare Part B 

      Schwartz, Aaron; Brennan, Troyen; Verbrugge, Dorothea; Newhouse, Joseph (American Medical Association (AMA), 2021-05-28)
      Importance: Health insurers use prior authorization to evaluate the medical necessity of planned medical services. Data challenges have precluded measuring the frequency with which medical services can require prior ...