Browsing SPH Scholarly Articles by Title

Now showing items 1807-1826 of 6362

    • Dysfunctional HDL and progression of atherosclerosis in HIV-1-infected and -uninfected adults 

      Kelesidis, Theodoros; Yang, Otto O; Kendall, Michelle Anne; Hodis, Howard N; Currier, Judith S (BioMed Central, 2013)
      Background: HDL function rather than absolute level may be a more accurate indicator for risk of developing atherosclerosis. Dysfunctional HDL has increased redox activity and reduced antioxidant properties, but it is ...

    • Dyslipidemia and the Risk of Incident Hypertension in Men 

      Halperin, R. O.; Sesso, H. D.; Ma, J.; Buring, J. E.; Stampfer, Meir; Michael Gaziano, J. (American Heart Association, 2005)
      Evidence suggests that hypertension may share a similar pathophysiology with cardiovascular disease (CVD). Thus, dyslipidemia, a strong predictor of CVD, may also predict incident hypertension. We analyzed 3110 men free ...

    • Dyslipidemia in an HIV-Positive Antiretroviral Treatment-Naive Population in Dar es Salaam, Tanzania 

      Armstrong, Catharina; Liu, Enju; Okuma, James; Spiegelman, Donna Lynn; Guerino, Chalamilla; Njelekela, Marina Alois; Grinspoon, Steven Kyle; Fawzi, Wafaie W.; Hawkins, Claudia (Ovid Technologies (Wolters Kluwer Health), 2011)
      Limited data are available on dyslipidemia in HIV-infected patients in resource-limited settings (RLS). We performed a cross-sectional analysis in ART-naïve, non-fasting HIV-infected patients in Tanzania between November ...

    • The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids 

      Hoxhaj, Gerta; Caddye, Edward; Najafov, Ayaz; Houde, Vanessa P; Johnson, Catherine; Dissanayake, Kumara; Toth, Rachel; Campbell, David G; Prescott, Alan R; MacKintosh, Carol (eLife Sciences Publications, Ltd, 2016)
      The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase). The membrane-associated ...

    • Early Adoption of Dabigatran and Its Dosing in US Patients With Atrial Fibrillation: Results From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation 

      Steinberg, Benjamin A.; Holmes, DaJuanicia N.; Piccini, Jonathan P.; Ansell, Jack; Chang, Paul; Fonarow, Gregg C.; Gersh, Bernard; Mahaffey, Kenneth W.; Kowey, Peter R.; Ezekowitz, Michael D.; Singer, Daniel E.; Thomas, Laine; Peterson, Eric D.; Hylek, Elaine M. (Blackwell Publishing Ltd, 2013)
      Background: Dabigatran is a novel oral anticoagulant approved for thromboprophylaxis in atrial fibrillation. Adoption patterns of this new agent in community practice are unknown. Methods and Results: We studied patterns ...

    • Early Antiretroviral Therapy Reduces AIDS Progression/Death in Individuals with Acute Opportunistic Infections: A Multicenter Randomized Strategy Trial 

      Zolopa, Andrew R.; Andersen, Janet W.; Komarow, Lauren Hope; Sanne, Ian; Sanchez, Alejandro; Hogg, Evelyn; Suckow, Carol; Powderly, William (Public Library of Science, 2009)
      Background: Optimal timing of ART initiation for individuals presenting with AIDS-related OIs has not been defined. Methods and Findings: A5164 was a randomized strategy trial of ‘‘early ART’’ - given within 14 days of ...

    • Early Blood Gas Predictors of Bronchopulmonary Dysplasia in Extremely Low Gestational Age Newborns 

      Sriram, Sudhir; Condie, Joy; Schreiber, Michael D.; Batton, Daniel G.; Shah, Bhavesh; Bose, Carl; Laughon, Matthew; Van Marter, Linda J.; Allred, Elizabeth N.; Leviton, Alan (Hindawi Publishing Corporation, 2014)
      Aim. To determine among infants born before the 28th week of gestation to what extent blood gas abnormalities during the first three postnatal days provide information about the risk of bronchopulmonary dysplasia (BPD). ...

    • Early child care and obesity at 12 months of age in the Danish National Birth Cohort 

      Neelon, Sara E Benjamin; Andersen, Camilla Schou; Morgen, Camilla Schmidt; Kamper-Jørgensen, Mads; Oken, Emily; Gillman, Matthew W; Sørensen, Thorkild IA (2014)
      Background/Objectives Evidence suggests that the child care environment may be more obesogenic than the family home, and previous studies have found that child care use may be associated with obesity in children. Few ...

    • Early Childhood Development and Schooling Attainment: Longitudinal Evidence from British, Finnish and Philippine Birth Cohorts 

      Peet, Evan D.; McCoy, Dana C.; Danaei, Goodarz; Ezzati, Majid; Fawzi, Wafaie; Jarvelin, Marjo-Riitta; Pillas, Demetris; Fink, Günther (Public Library of Science, 2015)
      Background: While recent literature has highlighted the importance of early childhood development for later life outcomes, comparatively little is known regarding the relative importance of early physical and cognitive ...

    • Early Childhood Developmental Status in Low- and Middle-Income Countries: National, Regional, and Global Prevalence Estimates Using Predictive Modeling 

      McCoy, Dana Charles; Peet, Evan D.; Ezzati, Majid; Danaei, Goodarz; Black, Maureen M.; Sudfeld, Christopher R.; Fawzi, Wafaie; Fink, Günther (Public Library of Science, 2016)
      Background: The development of cognitive and socioemotional skills early in life influences later health and well-being. Existing estimates of unmet developmental potential in low- and middle-income countries (LMICs) are ...

    • Early developmental trajectories associated with ASD in infants with tuberous sclerosis complex 

      Jeste, S. S.; Wu, Joyce Y.; Senturk, D.; Varcin, Kandice; Ko, J.; McCarthy, B.; Shimizu, C.; Dies, Kira Astrida; Vogel-Farley, V.; Sahin, Mustafa; Nelson, Charles A. (Ovid Technologies (Wolters Kluwer Health), 2014)
      OBJECTIVE: We performed a longitudinal cohort study of infants with tuberous sclerosis complex (TSC), with the overarching goal of defining early clinical, behavioral, and biological markers of autism spectrum disorder ...

    • Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE 

      Nguyen, H. Bryant; Jaehne, Anja Kathrin; Jayaprakash, Namita; Semler, Matthew W.; Hegab, Sara; Yataco, Angel Coz; Tatem, Geneva; Salem, Dhafer; Moore, Steven; Boka, Kamran; Gill, Jasreen Kaur; Gardner-Gray, Jayna; Pflaum, Jacqueline; Domecq, Juan Pablo; Hurst, Gina; Belsky, Justin B.; Fowkes, Raymond; Elkin, Ronald B.; Simpson, Steven Q.; Falk, Jay L.; Singer, Daniel J.; Rivers, Emanuel P. (BioMed Central, 2016)
      Prior to 2001 there was no standard for early management of severe sepsis and septic shock in the emergency department. In the presence of standard or usual care, the prevailing mortality was over 40-50 %. In response, a ...

    • Early life body fatness and risk of colorectal cancer in US women and men – results from two large cohort studies 

      Zhang, Xuehong; Wu, Kana; Giovannucci, Edward; Ma, Jing; Colditz, Graham; Fuchs, Charles; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Stampfer, Meir; Nimptsch, Katharina; Ogino, Shuji; Wei, Esther (American Association for Cancer Research, 2015)
      Background: The association between body fatness before adulthood and later risk of colorectal cancer remains unclear. We hypothesized that, independent of adult body fatness, early life body fatness would be associated ...

    • Early life environment and natural history of inflammatory bowel diseases 

      Guo, Abra Y; Stevens, Betsy W; Wilson, Robin G; Russell, Caitlin N; Cohen, Melissa A; Sturgeon, Holly C; Thornton, Anna; Giallourakis, Cosmas; Khalili, Hamed; Nguyen, Deanna D; Sauk, Jenny; Yajnik, Vijay; Xavier, Ramnik J; Ananthakrishnan, Ashwin N (BioMed Central, 2014)
      Background: Early life exposures may modify risk of inflammatory bowel diseases (IBD; Crohn’s disease (CD), ulcerative colitis (UC)). However, the relationship between early life exposures and natural history of IBD has ...

    • Early life-course socioeconomic position, adult work-related factors and oral health disparities: cross-sectional analysis of the J-SHINE study 

      Tsuboya, Toru; Aida, Jun; Kawachi, Ichiro; Katase, Kazuo; Osaka, Ken (BMJ Publishing Group, 2014)
      Objectives: We examined the association between socioeconomic position (SEP) and oral health, and the associations of economic difficulties in childhood and workplace-related factors on these parameters. Design: Cross-sectional ...

    • Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants 

      Morrow, Ardythe L; Lagomarcino, Anne J; Schibler, Kurt R; Taft, Diana H; Yu, Zhuoteng; Wang, Bo; Altaye, Mekibib; Wagner, Michael; Gevers, Dirk; Ward, Doyle V; Kennedy, Michael A; Huttenhower, Curtis; Newburg, David S (BioMed Central, 2013)
      Background: Necrotizing enterocolitis (NEC) is a devastating intestinal disease that afflicts 10% of extremely preterm infants. The contribution of early intestinal colonization to NEC onset is not understood, and predictive ...

    • Early Nutrition and Weight Gain in Preterm Newborns and the Risk of Retinopathy of Prematurity 

      VanderVeen, Deborah K.; Martin, Camilia R.; Mehendale, Reshma; Allred, Elizabeth N.; Dammann, Olaf; Leviton, Alan (Public Library of Science, 2013)
      Objective: To identify nutritional and weight gain limitations associated with retinopathy of prematurity (ROP) severity among very preterm newborns. Patients and Methods 1180 infants <28 weeks GA at birth with ROP examination ...

    • Early origins of inflammation: an examination of prenatal and childhood social adversity in a prospective cohort study 

      Slopen, Natalie; Loucks, Eric; Appleton, Allison; Kawachi, Ichiro; Kubzansky, Laura; Non, Amy; Buka, Stephen; Gilman, Stephen (2015)
      Background: Children exposed to social adversity carry a greater risk of poor physical and mental health into adulthood. This increased risk is thought to be due, in part, to inflammatory processes associated with early ...

    • Early Pregnancy Maternal Hepatocyte Growth Factor and Risk of Gestational Diabetes 

      Dishi, Michal; Hevner, Karin; Qiu, Chunfang; Fida, Neway G.; Abetew, Dejene F.; Williams, Michelle A.; Enquobahrie, Daniel A. (2016)
      Aims We investigated associations of serum hepatocyte growth factor (HGF) with risk of gestational diabetes mellitus (GDM). We also examined whether pre-pregnancy overweight/obesity status or leisure-time physical activity ...

    • Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study 

      Messinger, Daniel S.; Young, Gregory S.; Webb, Sara Jane; Ozonoff, Sally; Bryson, Susan E.; Carter, Alice; Carver, Leslie; Charman, Tony; Chawarska, Katarzyna; Curtin, Suzanne; Dobkins, Karen; Hertz-Picciotto, Irva; Hutman, Ted; Iverson, Jana M.; Landa, Rebecca; Nelson, Charles A.; Stone, Wendy L.; Tager-Flusberg, Helen; Zwaigenbaum, Lonnie (BioMed Central, 2015)
      Background: The increased male prevalence of autism spectrum disorder (ASD) may be mirrored by the early emergence of sex differences in ASD symptoms and cognitive functioning. The female protective effect hypothesis posits ...