Browsing SPH Scholarly Articles by Title

Now showing items 3064-3083 of 6362

    • An ignored risk factor in toxicology: The total imprecision of exposure assessment 

      Grandjean, Philippe; Budtz-Jørgensen, Esben (Walter de Gruyter GmbH, 2010)
      Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. ...

    • IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation 

      Mayo, Lior; Cunha, Andre Pires Da; Madi, Asaf; Beynon, Vanessa; Yang, Zhiping; Alvarez, Jorge I.; Prat, Alexandre; Sobel, Raymond A.; Kobzik, Lester; Lassmann, Hans; Quintana, Francisco J.; Weiner, Howard L. (Oxford University Press, 2016)
      See Winger and Zamvil (doi:10.1093/brain/aww121) for a scientific commentary on this article. The innate immune system plays a central role in the chronic central nervous system inflammation that drives neurological ...

    • IL-16 Promotes Leukotriene C4 and IL-4 Release from Human Eosinophils via CD4- and Autocrine CCR3-Chemokine-Mediated Signaling 

      Bandeira-Melo, C.; Sugiyama, K.; Woods, L. J.; Phoofolo, M.; Center, D. M.; Cruikshank, W. W.; Weller, Peter (The American Association of Immunologists, 2002)
      Human eosinophils are potential sources of inflammatory and immunomodulatory mediators, including cysteinyl leukotrienes, chemokines, and cytokines, which are pertinent to allergic inflammation. We evaluated the means by ...

    • IL-17 producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity 

      Kim, Hye Young; Lee, Hyun Jun; Chang, Ya-Jen; Pichavant, Muriel; Shore, Stephanie A.; Fitzgerald, Katherine A.; Iwakura, Yoichiro; Israel, Elliot; Bolger, Kenneth; Faul, John; DeKruyff, Rosemarie H.; Umetsu, Dale T. (2014)
      Obesity is associated with the development of asthma and considerable asthma-related healthcare utilization. To understand the immunological pathways that lead to obesity-associated asthma, we fed mice a high fat diet for ...

    • IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection 

      Adoro, Stanley; Cubillos-Ruiz, Juan R.; Chen, Xi; Deruaz, Maud; Vrbanac, Vladimir; Song, Minkyung; Park, Suna; Murooka, Thomas T.; Dudek, Timothy E.; Luster, Andrew D.; Tager, Andrew M.; Streeck, Hendrik; Bowman, Brittany; Walker, Bruce D.; Kwon, Douglas S.; Lazarevic, Vanja; Glimcher, Laurie H. (Nature Pub. Group, 2015)
      Initial events after exposure determine HIV-1 disease progression, underscoring a critical need to understand host mechanisms that interfere with initial viral replication. Although associated with chronic HIV-1 control, ...

    • Image-guided Coring for Large-scale Studies in Molecular Pathology 

      Montaser-Kouhsari, Laleh; Knoblauch, Nicholas W.; Oh, Eun-Yeong; Baker, Gabrielle; Christensen, Stephen; Hazra, Aditi; Tamimi, Rulla M.; Beck, Andrew H. (Lippincott Williams & Wilkins, 2016)
      Sampling of formalin-fixed paraffin-embedded (FFPE) tissue blocks is a critical initial step in molecular pathology. Image-guided coring (IGC) is a new method for using digital pathology images to guide tissue block coring ...

    • Imaging Lipid Bodies Within Leukocytes with Different Light Microscopy Techniques 

      Melo, Rossana C.N.; D’Ávila, Heloisa; Bozza, Patricia T.; Weller, Peter Fahey (Springer Science + Business Media, 2010)
      Lipid bodies, also known as lipid droplets, are present in most eukaryotic cells. In leukocytes, lipid bodies are functionally active organelles with central roles in inflammation and are considered structural markers of ...

    • Imaging Phenotype of Occupational Endotoxin-Related Lung Function Decline 

      Lai, Peggy S.; Hang, Jing-qing; Zhang, Feng-ying; Sun, J.; Zheng, Bu-Yong; Su, Li; Washko, George R.; Christiani, David C. (National Institute of Environmental Health Sciences, 2016)
      Background: Although occupational exposures contribute to a significant proportion of obstructive lung disease, the phenotype of obstructive lung disease associated with work-related organic dust exposure independent of ...

    • Immediate Risk for Cardiovascular Events and Suicide Following a Prostate Cancer Diagnosis: Prospective Cohort Study 

      Ye, Weimin; Andrén, Ove; Johansson, Jan-Erik; Andersson, Swen-Olof; Sparén, Pär; Klein, Georg; Valdimarsdóttir, Unnur; Franco, Eduardo L.; Fall, Katja; Fang, Fang; Mucci, Lorelei Ann; Stampfer, Meir; Adami, Hans-Olov (Public Library of Science, 2009)
      Background: Stressful life events have been shown to be associated with altered risk of various health consequences. The aim of the present study was to investigate whether the emotional stress evoked by a prostate cancer ...

    • Immediate Risk of Suicide and Cardiovascular Death After a Prostate Cancer Diagnosis: Cohort Study in the United States 

      Fang, Fang; Keating, Nancy L.; Mucci, Lorelei A.; Adami, Hans-Olov; Stampfer, Meir; Valdimarsdóttir, Unnur; Fall, Katja (Oxford University Press, 2010)
      Background Receiving a cancer diagnosis is a stressful event that may increase risks of suicide and cardiovascular death, especially soon after diagnosis.Methods We conducted a cohort study of 342 497 patients diagnosed ...

    • Immune Activation Markers in Peripartum Women in Botswana: Association with Feeding Strategy and Maternal Morbidity 

      Russell, Elizabeth S.; Mohammed, Terence; Smeaton, Laura Marie; Jorowe, Baitshepi; MacLeod, Iain James; Hoffman, Risa M.; Currier, Judith S.; Moyo, Sikhulile; Essex, Max; Lockman, Shahin (Public Library of Science (PLoS), 2014)
      Hormone levels shift the immune state in HIV-uninfected pregnant and breastfeeding women away from Th1 responses and toward regulation to permit fetal tolerance. Limited data exist on inflammation during pregnancy or ...

    • Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial 

      Gandhi, Rajesh T.; Kwon, Douglas S.; Macklin, Eric A.; Shopis, Janet R.; McLean, Anna P.; McBrine, Nicole; Flynn, Theresa; Peter, Lauren; Sbrolla, Amy; Kaufmann, Daniel E.; Porichis, Filippos; Walker, Bruce D.; Bhardwaj, Nina; Barouch, Dan H.; Kavanagh, Daniel G. (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2015)
      Background: HIV-1 eradication may require reactivation of latent virus along with stimulation of HIV-1-specific immune responses to clear infected cells. Immunization with autologous dendritic cells (DCs) transfected with ...

    • Immunocompromised Travelers: Demographic Characteristics, Travel Destinations, and Pretravel Health Care from the U.S. Global TravEpiNet Consortium 

      Schwartz, Brian S.; Rosen, Jessica; Han, Pauline V.; Hynes, Noreen A.; Hagmann, Stefan H.; Rao, Sowmya R.; Jentes, Emily S.; Ryan, Edward T.; LaRocque, Regina C. (The American Society of Tropical Medicine and Hygiene, 2015)
      An increasing number of immunocompromised individuals are pursuing international travel, and a better understanding of their international travel patterns and pretravel health care is needed. We evaluated the clinical ...

    • Immunodominant HIV-1 Cd4+ T Cell Epitopes in Chronic Untreated Clade C HIV-1 Infection 

      Ramduth, Danni; Day, Cheryl L.; Thobakgale, Christina F.; Mkhwanazi, Nompumelelo P.; de Pierres, Chantal; Reddy, Sharon; van der Stok, Mary; Mncube, Zenele; Nair, Kriebashne; Moodley, Eshia S.; Coovadia, Hoosen M.; Kiepiela, Photini; Kaufmann, Daniel; Streeck, Hendrik; Goulder, Philip J.; Walker, Bruce David (Public Library of Science, 2009)
      Background: A dominance of Gag-specific CD8+ T cell responses is significantly associated with a lower viral load in individuals with chronic, untreated clade C human immunodeficiency virus type 1 (HIV-1) infection. This ...

    • Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality 

      Mkhwanazi, Nompumelelo; Thobakgale, Christina F.; van der Stok, Mary; Reddy, Shabashini; Mncube, Zenele; Chonco, Fundisiwe; Walker, Bruce David; Altfeld, Marcus; Goulder, Philip J.; Ndung'u, Thumbi (Academic Press, 2010)
      HIV-1 specific HLA-B-restricted CD8+ T cell responses differ from HLA-C-restricted responses in antiviral effectiveness. To investigate possible reasons for these differences, we characterized the frequency and polyfunctionality ...

    • Immunogenicity of a Killed Bivalent (O1 and O139) Whole Cell Oral Cholera Vaccine, Shanchol, in Haiti 

      Charles, Richelle C.; Hilaire, Isabelle J.; Mayo-Smith, Leslie M.; Teng, Jessica E.; Jerome, J. Gregory; Franke, Molly F.; Saha, Amit; Yu, Yanan; Kováč, Paul; Calderwood, Stephen B.; Ryan, Edward T.; LaRocque, Regina C.; Almazor, Charles P.; Qadri, Firdausi; Ivers, Louise C.; Harris, Jason B. (Public Library of Science, 2014)
      Background: Studies of the immunogenicity of the killed bivalent whole cell oral cholera vaccine, Shanchol, have been performed in historically cholera-endemic areas of Asia. There is a need to assess the immunogenicity ...

    • Immunohaematological reference values for HIV-negative healthy adults in Botswana 

      Mine, Madisa; Moyo, Sikhulile; Stevens, Penny; Michael, Kurt; Novitsky, Vladimir A.; Makhaola, Kgomotso; Asmelash, Aida; Molefhabangwe, S’khatele; Woldegabriel, Elias; Mothowaeng, Gaseboloke; Maruta, Talkmore; Kamhukamwe, Charity; Mangwendeza, Phibeon M.; Holmes-Pretorius, Molly; Mtoni, Isaac; Motswaledi, Modisa; Musonda, Rosemary Mubanga; Ndwapi, Ndwapi; Makhema, Joseph Moeketsi; Marlink, Richard G.; Seipone, Khumo; Gaolathe, Tendani; Essex, Myron Elmer (AOSIS, 2011)
      BACKGROUND: Clinical laboratories in Botswana have relied entirely on the reference intervals for normal immunohaematological values provided by manufacturers' kits and textbooks. OBJECTIVES: The aim of this study was to ...

    • Immunohistochemical expression of BRCA1 and lethal prostate cancer 

      Fiorentino, Michelangelo; Judson, Gregory; Penney, Kathryn; Flavin, Richard; Stark, Jennifer; Fiore, Christopher; Fall, Katja; Martin, Neil; Ma, Jing; Sinnott, Jennifer; Giovannucci, Edward; Stampfer, Meir; Sesso, Howard D.; Kantoff, Philip W.; Finn, Stephen; Loda, Massimo; Mucci, Lorelei (American Association for Cancer Research, 2010)
      BRCA1 functions as a tumor suppressor; recent work suggests that BRCA1 may also induce cell cycle arrest to allow for DNA repair. We hypothesized that BRCA1 expression in prostate tumor tissue may be associated with prostate ...

    • Immunologic Responses to Vibrio cholerae in Patients Co-Infected with Intestinal Parasites in Bangladesh 

      Bhuiyan, Taufiqur R.; Chowdhury, Fahima; Khan, Ashraful I.; Logvinenko, Tanya; Kendall, Jennifer; Faruque, Abu S. G.; Nagler, Cathryn R.; Qadri, Firdausi; Harris, Jason B.; Podolsky, Michael Jeffrey; Larocque, Regina Celes; Ryan, Edward Thomas; Calderwood, Stephen Beaven (Public Library of Science, 2009)
      Background: Infection with intestinal helminths is common and may contribute to the decreased efficacy of Vibrio cholerae vaccines in endemic compared to non-endemic areas. However, the immunomodulatory effects of concomitant ...

    • Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways 

      Bhargava, Prerna; Li, Changlin; Stanya, Kristopher J; Jacobi, David; Dai, Lingling; Liu, Sihao; Gangl, Matthew; Harn, Donald A.; Lee, Chih-Hao (2012)
      Parasitic worms express host-like glycans to attenuate the immune response of human hosts. The therapeutic potential of this immunomodulatory mechanism in controlling metabolic dysfunction associated with chronic inflammation ...