Browsing SPH Scholarly Articles by Title

Now showing items 3904-3923 of 6362

    • MethylPurify: tumor purity deconvolution and differential methylation detection from single tumor DNA methylomes 

      Zheng, Xiaoqi; Zhao, Qian; Wu, Hua-Jun; Li, Wei; Wang, Haiyun; Meyer, Clifford A; Qin, Qian Alvin; Xu, Han; Zang, Chongzhi; Jiang, Peng; Li, Fuqiang; Hou, Yong; He, Jianxing; Wang, Jun; Zhang, Peng; Zhang, Yong; Liu, Xiaole Shirley (BioMed Central, 2014)
      We propose a statistical algorithm MethylPurify that uses regions with bisulfite reads showing discordant methylation levels to infer tumor purity from tumor samples alone. MethylPurify can identify differentially methylated ...

    • Metronomic Chemotherapy Was Originally Designed and First Used in 1994 for Early Stage Cancer -- Why Is It Taking So Long to Proceed? 

      Retsky, Michael W. (OMICS Publishing Group, 2011)
      This is a personal case history from a researcher who was studying tumor growth when diagnosed in 1994 with stage IIIc colon cancer. The risk of relapse was 80% without therapy and 50% with conventional therapy. However ...

    • MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers 

      Shima, Kaori; Morikawa, Teppei; Baba, Yoshifumi; Nosho, Katsuhiko; Suzuki, Maiko; Yamauchi, Mai; Hayashi, Marika; Giovannucci, Edward; Fuchs, Charles S.; Ogino, Shuji (Springer (part of Springer Nature), 2011)
      O (6)-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme. MGMT promoter hypermethylation and epigenetic silencing often occur as early events in carcinogenesis. However, prognostic significance of MGMT ...

    • Microbial Co-occurrence Relationships in the Human Microbiome 

      Faust, Karoline; Sathirapongsasuti, Jarupon Fah; Izard, Jacques Georges; Segata, Nicola; Gevers, Dirk; Raes, Jeroen; Huttenhower, Curtis (Public Library of Science, 2012)
      The healthy microbiota show remarkable variability within and among individuals. In addition to external exposures, ecological relationships (both oppositional and symbiotic) between microbial inhabitants are important ...

    • Microbial Community Function and Biomarker Discovery in the Human Microbiome 

      Abubucker, Sahar; Goll, Johannes; Schubert, Alyxandria M; Cantarel, Brandi L; Rodriguez-Mueller, Beltran; Thiagarajan, Mathangi; Henrissat, Bernard; White, Owen; Kelley, Scott T; Methé, Barbara; Schloss, Patrick D; Gevers, Dirk; Mitreva, Makedonka; Izard, Jacques Georges; Waldron, Levi D.; Zucker, Jeremy Daniel Hofeld; Garrett, Wendy S.; Huttenhower, Curtis; Segata, Nicola (BioMed Central, 2011)

    • The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis 

      Smith, Patrick M.; Howitt, Michael; Panikov, Nicolai; Michaud, Monia; Gallini, Carey Ann; Bohlooly-Y, Mohammad; Glickman, Jonathan Neil; Garrett, Wendy S. (American Association for the Advancement of Science (AAAS), 2013)
      Regulatory T cells (Tregs) that express the transcription factor Foxp3 are critical for regulating intestinal inflammation. Candidate microbe approaches have identified bacterial species and strain-specific molecules that ...

    • Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals 

      Asnicar, Francesco; Berry, Sarah E.; Valdes, Ana M.; Nguyen, Long; Piccinno, Gianmarco; Drew, David; Leeming, Emily; Gibson, Rachel; Le Roy, Caroline; Al Khatib, Haya; Francis, Lucy; Mazidi, Mohsen; Mompeo, Olatz; Valles-Colomer, Mireia; Tett, Adrian; Beghini, Francesco; Dubois, Léonard; Bazzani, Davide; Thomas, Andrew Maltez; Mirzayi, Chloe; Khleborodova, Asya; Oh, Sehyun; Hine, Rachel; Bonnett, Christopher; Capdevila, Joan; Danzanvilliers, Serge; Giordano, Francesca; Geistlinger, Ludwig; Waldron, Levi; Davies, Richard; Hadjigeorgiou, George; Wolf, Jonathan; Ordovás, José M.; Gardner, Christopher D.; Franks, Paul; Chan, Andrew; Huttenhower, Curtis; Spector, Tim D.; Segata, Nicola (Springer Science and Business Media LLC, 2021-01-11)
      The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 ...

    • The microbiome quality control project: baseline study design and future directions 

      Sinha, Rashmi; Abnet, Christian C.; White, Owen; Knight, Rob; Huttenhower, Curtis (BioMed Central, 2015)
      Microbiome research has grown exponentially over the past several years, but studies have been difficult to reproduce across investigations. Relevant variation in measurements between laboratories, from a variety of sources, ...

    • A Microchip CD4 Counting Method for HIV Monitoring in Resource-Poor Settings 

      Christodoulides, Nicolaos; Floriano, Pierre N; Graham, Susan; Mohanty, Sanghamitra; Dixon, Meredith; Hsiang, Mina; Peter, Trevor; Zavahir, Shabnam; Romanovicz, Dwight; Bernard, Bruce; Goodey, Adrian P; McDevitt, John T; Rodriguez, William Richard; Thior, Ibou; Walker, Bruce David (Public Library of Science, 2005)
      Background: More than 35 million people in developing countries are living with HIV infection. An enormous global effort is now underway to bring antiretroviral treatment to at least 3 million of those infected. While drug ...

    • Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania 

      Kawai, K.; Meydani, S. N.; Urassa, W.; Wu, D.; Mugusi, F. M.; Saathoff, E.; Bosch, R. J.; Villamor, E.; Spiegelman, D.; Fawzi, W. W. (Cambridge University Press, 2014)
      Limited studies exist regarding whether incorporating micronutrient supplements during tuberculosis (TB) treatment may improve cell-mediated immune response. We examined the effect of micronutrient supplementation on ...

    • MicroRNA Related Polymorphisms and Breast Cancer Risk 

      Khan, Sofia; Greco, Dario; Michailidou, Kyriaki; Milne, Roger L.; Muranen, Taru A.; Heikkinen, Tuomas; Aaltonen, Kirsimari; Dennis, Joe; Bolla, Manjeet K.; Liu, Jianjun; Hall, Per; Irwanto, Astrid; Humphreys, Keith; Li, Jingmei; Czene, Kamila; Chang-Claude, Jenny; Hein, Rebecca; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Fletcher, Olivia; Peto, Julian; dos Santos Silva, Isabel; Johnson, Nichola; Gibson, Lorna; Aitken, Zoe; Hopper, John L.; Tsimiklis, Helen; Bui, Minh; Makalic, Enes; Schmidt, Daniel F.; Southey, Melissa C.; Apicella, Carmel; Stone, Jennifer; Waisfisz, Quinten; Meijers-Heijboer, Hanne; Adank, Muriel A.; van der Luijt, Rob B.; Meindl, Alfons; Schmutzler, Rita K.; Müller-Myhsok, Bertram; Lichtner, Peter; Turnbull, Clare; Rahman, Nazneen; Chanock, Stephen J.; Hunter, David J.; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Schmidt, Marjanka K.; Broeks, Annegien; Veer, Laura J. V. a. n't.; Hogervorst, Frans B.; Fasching, Peter A.; Schrauder, Michael G.; Ekici, Arif B.; Beckmann, Matthias W.; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Benitez, Javier; Zamora, Pilar M.; Perez, Jose I. A.; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Pharoah, Paul D. P.; Dunning, Alison M.; Shah, Mitul; Luben, Robert; Brown, Judith; Couch, Fergus J.; Wang, Xianshu; Vachon, Celine; Olson, Janet E.; Lambrechts, Diether; Moisse, Matthieu; Paridaens, Robert; Christiaens, Marie-Rose; Guénel, Pascal; Truong, Thérèse; Laurent-Puig, Pierre; Mulot, Claire; Marme, Frederick; Burwinkel, Barbara; Schneeweiss, Andreas; Sohn, Christof; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Andrulis, Irene L.; Knight, Julia A.; Tchatchou, Sandrine; Mulligan, Anna Marie; Dörk, Thilo; Bogdanova, Natalia V.; Antonenkova, Natalia N.; Anton-Culver, Hoda; Darabi, Hatef; Eriksson, Mikael; Garcia-Closas, Montserrat; Figueroa, Jonine; Lissowska, Jolanta; Brinton, Louise; Devilee, Peter; Tollenaar, Robert A. E. M.; Seynaeve, Caroline; van Asperen, Christi J.; Kristensen, Vessela N.; Slager, Susan; Toland, Amanda E.; Ambrosone, Christine B.; Yannoukakos, Drakoulis; Lindblom, Annika; Margolin, Sara; Radice, Paolo; Peterlongo, Paolo; Barile, Monica; Mariani, Paolo; Hooning, Maartje J.; Martens, John W. M.; Collée, J. Margriet; Jager, Agnes; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Giles, Graham G.; McLean, Catriona; Brauch, Hiltrud; Brüning, Thomas; Ko, Yon-Dschun; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Stegmaier, Christa; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Jones, Michael; Simard, Jacques; Goldberg, Mark S.; Labrèche, France; Dumont, Martine; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Mannermaa, Arto; Hamann, Ute; Chenevix-Trench, Georgia; Blomqvist, Carl; Aittomäki, Kristiina; Easton, Douglas F.; Nevanlinna, Heli (Public Library of Science, 2014)
      Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or in the miRNA binding sites may affect the miRNA dependent gene expression regulation, which has been implicated in various cancers, ...

    • MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability 

      Choi, Young Eun; Pan, Yunfeng; Park, Eunmi; Konstantinopoulos, Panagiotis; De, Subhajyoti; D'Andrea, Alan; Chowdhury, Dipanjan (eLife Sciences Publications, Ltd, 2014)
      Homologous recombination (HR)-mediated repair of DNA double-strand break (DSB)s is restricted to the post-replicative phases of the cell cycle. Initiation of HR in the G1 phase blocks non-homologous end joining (NHEJ) ...

    • Microvesicle-associated microRNA expression is altered upon particulate matter exposure in healthy workers and in A549 cells 

      Bollati, Valentina; Angelici, Laura; Rizzo, Giovanna; Pergoli, Laura; Rota, Federica; Hoxha, Mirjam; Nordio, Francesco; Bonzini, Matteo; Tarantini, Letizia; Cantone, Laura; Pesatori, Angela C; Apostoli, Pietro; Baccarelli, Andrea A; Bertazzi, Pier Alberto (BlackWell Publishing Ltd, 2014)
      Cardiovascular disease risk has been consistently linked with particulate matter (PM) exposure. Cell-derived microvesicles (MVs) are released into plasma and transfer microRNAs (miRNAs) between tissues. MVs can be produced ...

    • Migraine and Cognitive Decline Among Women: Prospective Cohort Study 

      Rist, Pamela Marie; Kang, Jae Hee Hee; Buring, Julie Elizabeth; Glymour, Maria Lee; Grodstein, Francine; Kurth, Tobias (BMJ Publishing Group Ltd., 2012)
      Objective: To evaluate the association between migraine and cognitive decline among women. Design Prospective cohort study. Setting Women’s Health Study, United States. Participants 6349 women aged 65 or older enrolled in ...

    • Migraine and risk of cardiovascular disease in women: prospective cohort study 

      Kurth, Tobias; Winter, Anke C.; Eliassen, A. Heather; Dushkes, Rimma; Mukamal, Kenneth J.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Manson, JoAnn E.; Rexrode, Kathryn M. (2016)
      OBJECTIVE To evaluate the association between migraine and incident cardiovascular disease and cardiovascular mortality in women.DESIGN Prospective cohort study among Nurses' Health Study II participants, with follow-up ...

    • Migraine and risk of haemorrhagic stroke in women: prospective cohort study 

      Kurth, Tobias; Kase, Carlos S; Schürks, Markus; Tzourio, Christophe; Buring, Julie Elizabeth (BMJ Publishing Group Ltd., 2010)
      Objectives: To examine the association between migraine and migraine aura status with risk of haemorrhagic stroke. Design: Prospective cohort study. Setting: Women’s Health Study, United States. Participants: 27 860 women ...

    • Migraine, Vascular Risk, and Cardiovascular Events in Women: Prospective Cohort Study 

      Schürks, Markus; Logroscino, Giancarlo; Kurth, Tobias; Gaziano, John Michael; Buring, Julie Elizabeth (BMJ Publishing Group, 2008)
      Objectives: To evaluate whether the association between migraine with aura and increased risk of cardiovascular disease is modified by vascular risk groups as measured by the Framingham risk score for coronary heart disease. ...

    • Migraine-Asthma Comorbidity and Risk of Hypertensive Disorders of Pregnancy 

      Czerwinski, Stefanie; Gollero, Jolana; Qiu, Chunfang; Sorensen, Tanya K.; Williams, Michelle A. (Hindawi Publishing Corporation, 2012)
      Background: To evaluate the association of migraine and asthma and to estimate the risk of hypertensive disorders of pregnancy in relation to maternal comorbid migraine and asthma. Methods: Reproductive age women (N = ...

    • Milestones and Impact Factors 

      Ozonoff, David M.; Grandjean, Philippe (BioMed Central, 2010)
      Environmental Health has just received its first Impact Factor by Thomson ISI. At a level of 2.48, this achievement is quite satisfactory and places Environmental Health in the top 25% of environmental science journals. ...

    • Military Service and Amyotrophic Lateral Sclerosis in a Population-based Cohort 

      Weisskopf, Marc G.; Cudkowicz, Merit E.; Johnson, Norman (Lippincott Williams & Wilkins, 2015)
      Background: Military service has been suggested to be associated with an increased risk of amyotrophic lateral sclerosis (ALS), but only one prospective study—of a volunteer cohort—has examined this question. Methods: We ...