Browsing SPH Scholarly Articles by Title

Now showing items 4162-4181 of 6362

    • No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis 

      Loley, Christina; Alver, Maris; Assimes, Themistocles L.; Bjonnes, Andrew; Goel, Anuj; Gustafsson, Stefan; Hernesniemi, Jussi; Hopewell, Jemma C.; Kanoni, Stavroula; Kleber, Marcus E.; Lau, King Wai; Lu, Yingchang; Lyytikäinen, Leo-Pekka; Nelson, Christopher P.; Nikpay, Majid; Qu, Liming; Salfati, Elias; Scholz, Markus; Tukiainen, Taru; Willenborg, Christina; Won, Hong-Hee; Zeng, Lingyao; Zhang, Weihua; Anand, Sonia S.; Beutner, Frank; Bottinger, Erwin P.; Clarke, Robert; Dedoussis, George; Do, Ron; Esko, Tõnu; Eskola, Markku; Farrall, Martin; Gauguier, Dominique; Giedraitis, Vilmantas; Granger, Christopher B.; Hall, Alistair S.; Hamsten, Anders; Hazen, Stanley L.; Huang, Jie; Kähönen, Mika; Kyriakou, Theodosios; Laaksonen, Reijo; Lind, Lars; Lindgren, Cecilia; Magnusson, Patrik K. E.; Marouli, Eirini; Mihailov, Evelin; Morris, Andrew P.; Nikus, Kjell; Pedersen, Nancy; Rallidis, Loukianos; Salomaa, Veikko; Shah, Svati H.; Stewart, Alexandre F. R.; Thompson, John R.; Zalloua, Pierre A.; Chambers, John C.; Collins, Rory; Ingelsson, Erik; Iribarren, Carlos; Karhunen, Pekka J.; Kooner, Jaspal S.; Lehtimäki, Terho; Loos, Ruth J. F.; März, Winfried; McPherson, Ruth; Metspalu, Andres; Reilly, Muredach P.; Ripatti, Samuli; Sanghera, Dharambir K.; Thiery, Joachim; Watkins, Hugh; Deloukas, Panos; Kathiresan, Sekar; Samani, Nilesh J.; Schunkert, Heribert; Erdmann, Jeanette; König, Inke R. (Nature Publishing Group, 2016)
      In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been ...

    • No changes in lymphocyte muscarinic receptors and platelet monoamine oxidase-B examined as surrogate central nervous system biomarkers in a Faroese children cohort prenatally exposed to methylmercury and polychlorinated biphenyls 

      Coccini, Teresa; Manzo, Luigi; Debes, Frodi; Steuerwald, Ulrike; Weihe, Pal; Grandjean, Philippe (Informa UK Limited, 2009)
      Experimental evidence suggests that monoamine oxidase B (MAO-B) and muscarinic cholinergic receptors (mAChRs) are involved in the pathogenesis of neurotoxicity caused by methylmercury and polychlorinated biphenyls (PCBs). ...

    • No coexistence for free: Neutral null models for multistrain pathogens 

      Lipsitch, Marc; Colijn, Caroline; Cohen, Ted; Hanage, William P.; Fraser, Christophe (Elsevier BV, 2009)
      In most pathogens, multiple strains are maintained within host populations. Quantifying the mechanisms underlying strain coexistence would aid public health planning and improve understanding of disease dynamics. We argue ...

    • No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects 

      Baumert, Jens; Huang, Jie; McKnight, Barbara; Sabater-Lleal, Maria; Steri, Maristella; Chu, Audrey Y.; Trompet, Stella; Lopez, Lorna M.; Fornage, Myriam; Teumer, Alexander; Tang, Weihong; Rudnicka, Alicja R.; Mälarstig, Anders; Hottenga, Jouke-Jan; Kavousi, Maryam; Lahti, Jari; Tanaka, Toshiko; Hayward, Caroline; Huffman, Jennifer E.; Morange, Pierre-Emmanuel; Rose, Lynda M.; Basu, Saonli; Rumley, Ann; Stott, David J.; Buckley, Brendan M.; de Craen, Anton J. M.; Sanna, Serena; Masala, Marco; Biffar, Reiner; Homuth, Georg; Silveira, Angela; Sennblad, Bengt; Goel, Anuj; Watkins, Hugh; Müller-Nurasyid, Martina; Rückerl, Regina; Taylor, Kent; Chen, Ming-Huei; de Geus, Eco J. C.; Hofman, Albert; Witteman, Jacqueline C. M.; de Maat, Moniek P. M.; Palotie, Aarno; Davies, Gail; Siscovick, David S.; Kolcic, Ivana; Wild, Sarah H.; Song, Jaejoon; McArdle, Wendy L.; Ford, Ian; Sattar, Naveed; Schlessinger, David; Grotevendt, Anne; Franzosi, Maria Grazia; Illig, Thomas; Waldenberger, Melanie; Lumley, Thomas; Tofler, Geoffrey H.; Willemsen, Gonneke; Uitterlinden, André G.; Rivadeneira, Fernando; Räikkönen, Katri; Chasman, Daniel I.; Folsom, Aaron R.; Lowe, Gordon D.; Westendorp, Rudi G. J.; Slagboom, P. Eline; Cucca, Francesco; Wallaschofski, Henri; Strawbridge, Rona J.; Seedorf, Udo; Koenig, Wolfgang; Bis, Joshua C.; Mukamal, Kenneth J.; van Dongen, Jenny; Widen, Elisabeth; Franco, Oscar H.; Starr, John M.; Liu, Kiang; Ferrucci, Luigi; Polasek, Ozren; Wilson, James F.; Oudot-Mellakh, Tiphaine; Campbell, Harry; Navarro, Pau; Bandinelli, Stefania; Eriksson, Johan; Boomsma, Dorret I.; Dehghan, Abbas; Clarke, Robert; Hamsten, Anders; Boerwinkle, Eric; Jukema, J. Wouter; Naitza, Silvia; Ridker, Paul M.; Völzke, Henry; Deary, Ian J.; Reiner, Alexander P.; Trégouët, David-Alexandre; O'Donnell, Christopher J.; Strachan, David P.; Peters, Annette; Smith, Nicholas L. (Public Library of Science, 2014)
      Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies ...

    • No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels 

      Scott, Robert A.; Chu, Audrey Yu-lei; Grarup, Niels; Manning, Alisa K.; Hivert, Marie-France; Shungin, Dmitry; Tönjes, Anke; Yesupriya, Ajay; Barnes, Daniel; Bouatia-Naji, Nabila; Glazer, Nicole L.; Jackson, Anne U.; Kutalik, Zoltán; Lagou, Vasiliki; Marek, Diana; Rasmussen-Torvik, Laura J.; Stringham, Heather M.; Tanaka, Toshiko; Aadahl, Mette; Arking, Dan E.; Bergmann, Sven; Boerwinkle, Eric; Bonnycastle, Lori L.; Bornstein, Stefan R.; Brunner, Eric; Bumpstead, Suzannah J.; Brage, Soren; Carlson, Olga D.; Chen, Han; Chen, Yii-Der Ida; Chines, Peter S.; Collins, Francis S.; Couper, David J.; Dennison, Elaine M.; Dowling, Nicole F.; Egan, Josephine S.; Ekelund, Ulf; Erdos, Michael R.; Forouhi, Nita G.; Fox, Caroline; Goodarzi, Mark O.; Grässler, Jürgen; Gustafsson, Stefan; Hallmans, Göran; Hansen, Torben; Hingorani, Aroon; Holloway, John W.; Hu, Frank B.; Isomaa, Bo; Jameson, Karen A.; Johansson, Ingegerd; Jonsson, Anna; Jørgensen, Torben; Kivimaki, Mika; Kovacs, Peter; Kumari, Meena; Kuusisto, Johanna; Laakso, Markku; Lecoeur, Cécile; Lévy-Marchal, Claire; Li, Guo; Loos, Ruth J.F.; Lyssenko, Valeri; Marmot, Michael; Marques-Vidal, Pedro; Morken, Mario A.; Müller, Gabriele; North, Kari E.; Pankow, James S.; Payne, Felicity; Prokopenko, Inga; Psaty, Bruce M.; Renström, Frida; Rice, Ken; Rotter, Jerome I.; Rybin, Denis; Sandholt, Camilla H.; Sayer, Avan A.; Shrader, Peter; Schwarz, Peter E.H.; Siscovick, David S.; Stančáková, Alena; Stumvoll, Michael; Teslovich, Tanya M.; Waeber, Gérard; Williams, Gordon Harold; Witte, Daniel R.; Wood, Andrew R.; Xie, Weijia; Boehnke, Michael; Cooper, Cyrus; Ferrucci, Luigi; Froguel, Philippe; Groop, Leif; Kao, W.H. Linda; Vollenweider, Peter; Walker, Mark; Watanabe, Richard M.; Pedersen, Oluf; Meigs, James Benjamin; Ingelsson, Erik; Barroso, Inês; Florez, Jose Carlos; Franks, Paul W.; Dupuis, Josée; Wareham, Nicholas J.; Langenberg, Claudia (American Diabetes Association, 2012)
      Gene–lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both ...

    • No sweat: African American adolescent girls’ opinions of hairstyle choices and physical activity 

      Woolford, Susan J.; Woolford-Hunt, Carole J.; Sami, Areej; Blake, Natalie; Williams, David R. (BioMed Central, 2016)
      Background: Obesity prevalence is higher among African American adolescent (AAA) girls than among non-black girls. Lower levels of physical activity (PA) likely contribute to this disparity; this may be impacted by hairstyle ...

    • NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis 

      Pandey, Amit K.; Yang, Yibin; Jiang, Zhaozhao; Fortune, Sarah Merritt; Coulombe, Francois; Behr, Marcel A.; Fitzgerald, Katherine A.; Sassetti, Christopher M.; Kelliher, Michelle A. (Public Library of Science, 2009)
      While the recognition of microbial infection often occurs at the cell surface via Toll-like receptors, the cytosol of the cell is also under surveillance for microbial products that breach the cell membrane. An important ...

    • Non-cell autonomous tumor-growth driving supports sub-clonal heterogeneity 

      Marusyk, Andriy; Tabassum, Doris P.; Altrock, Philipp M.; Almendro, Vanessa; Michor, Franziska; Polyak, Kornelia (2014)
      SUMMARY Cancers arise through a process of somatic evolution that can result in substantial sub-clonal heterogeneity within tumors. The mechanisms responsible for the coexistence of distinct sub-clones and the biological ...

    • Non-communicable diseases in sub-Saharan Africa: the case for cohort studies 

      Holmes, Michelle D.; Dalal, Shona; Volmink, Jimmy; Adebamowo, Clement Adebayo; Njelekela, Marina; Fawzi, Wafaie W.; Willett, Walter C.; Adami, Hans-Olov (Public Library of Science, 2010)
      Michelle Holmes and colleagues argue that there is an urgent need for longitudinal cohorts based in sub-Saharan Africa to address the growing burden of noncommunicable diseases in the region.

    • Non-HDL Cholesterol and Apolipoprotein B Predict Cardiovascular Disease Events Among Men with Type 2 Diabetes 

      Jiang, R.; Schulze, M. B.; Li, T.; Rifai, N.; Stampfer, Meir; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Hu, F. B. (American Diabetes Association, 2004)

    • Non-High-Density Lipoprotein Cholesterol on the Risks of Stroke: A Result from the Kailuan Study 

      Wu, Jianwei; Chen, Shengyun; Zhou, Yong; Wang, Chunxue; Wang, Anxin; Zhang, Qian; Gao, Xiang; Hu, Haitao; Wu, Shouling; Zhao, Xingquan (Public Library of Science, 2013)
      Aims To prospectively explore the association between non-high-density lipoprotein cholesterol (non-HDLC) and the risks of stroke and its subtypes. Methods: A total of 95,916 participants (18-98 years old; 76,354 men and ...

    • Non-Immunogenicity of Overlapping Gag Peptides Pulsed on Autologous Cells after Vaccination of HIV Infected Individuals 

      Kløverpris, Henrik N.; Jackson, Akil; Handley, Amanda; Hayes, Peter; Gilmour, Jill; Riddell, Lynn; Chen, Fabian; Atkins, Mark; Boffito, Marta; Walker, Bruce D.; Ackland, Jim; Sullivan, Mark; Goulder, Philip (Public Library of Science, 2013)
      Background: HIV Gag-specific CD4+ and CD8+ T-cell responses are important for HIV immune control. Pulsing overlapping Gag peptides on autologous lymphocytes (OPAL) has proven immunogenic and effective in reducing viral ...

    • The Non-Linear Risk of Mortality by Income Level in a Healthy Population: US National Health and Nutrition Examination Survey mortality Follow-up Cohort, 1988-2001 

      Rehkopf, David H; Berkman, Lisa; Coull, Brent; Krieger, Nancy (BioMed Central, 2008)
      Background: An examination of where in the income distribution income is most strongly associated with risk of mortality will provide guidance for identifying the most critical pathways underlying the connections between ...

    • Non-Narcotic Analgesic Dose and Risk of Incident Hypertension in US Women 

      Forman, J. P.; Stampfer, Meir; Curhan, G. C. (American Heart Association, 2005)
      Acetaminophen, ibuprofen, and aspirin are the most commonly used drugs in the United States. Although the frequency of their use has been associated with hypertension, prospective data examining the dose of these drugs and ...

    • Non-precautionary aspects of toxicology 

      Grandjean, Philippe (Elsevier BV, 2005)
      Empirical studies in toxicology aim at deciphering complex causal relationships, especially in regard to human disease etiologies. Several scientific traditions limit the usefulness of documentation from current toxicological ...

    • Non-surgical interventions for pelvic organ prolapse in rural Nepal: a prospective monitoring and evaluation study 

      Fitchett, Joseph R; Bhatta, Surya; Sherpa, Tenzing Y; Malla, Bishwo S; A Fitchett, Elizabeth J; Samen, Arlene; Kristensen, Sibylle (SAGE Publications, 2015)
      Objectives: Pelvic organ prolapse (POP) is a major cause of morbidity in Nepal, particularly affecting women in the rural communities. Women with POP in Nepal may suffer from symptoms for decades. At present, the Government ...

    • Nonalcoholic Fatty Liver Disease: Cytokine-Adipokine Interplay and Regulation of Insulin Resistance 

      Tilg, Herbert; Hotamisligil, Gokhan (Elsevier BV, 2006-09)

    • Nondense Mammographic Area and Risk of Breast Cancer 

      Pettersson, Andreas; Hankinson, Susan Elizabeth; Willett, Walter C.; Lagiou, Pagona; Trichopoulos, Dimitrios; Tamimi, Rulla May (BioMed Central, 2011)
      Introduction: The mechanisms underlying the strong association between percentage dense area on a mammogram and the risk of breast cancer are unknown. We investigated separately the absolute dense area and the absolute ...

    • Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor 

      Trujillo, J. R.; Rogers, Rick A.; Molina, Ramon M.; Dangond, F; McLane, Mary Frances; Essex, Myron Elmer; Brain, Joseph David (Proceedings of the National Academy of Sciences, 2007)
      Although protein receptors on the plasma membrane involved in the initial steps of productive HIV-1 infection have been well characterized, little is known about interactions between cellular carbohydrate receptors and ...

    • Nonnarcotic Analgesic Use and the Risk of Hypertension in US Women 

      Dedier, J.; Stampfer, Meir; Hankinson, S. E.; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Speizer, F. E.; Curhan, G. C. (American Heart Association, 2002)
      Acetaminophen, aspirin, and other nonsteroidal anti-inflammatory drugs (NSAIDs) are widely consumed. Each is theoretically capable of elevating blood pressure by altering prostaglandin homeostasis; however, there is little ...