Now showing items 44-63 of 6224

    • A novel fatty acid lipophilic index and risk of CHD in US men: the Health Professionals Follow-Up Study 

      Wu, Hongyu; Ding, Eric L.; Toledo, Estefanía T.; Campos, Hannia; Baylin, Ana; Hu, Frank B.; Sun, Qi (Cambridge University Press, 2013)
      Few epidemiological studies have examined the association between an overall fatty acid (FA) profile and CHD risk. The aim of the present study was to examine a novel index that summarises individual FA levels based on FA ...
    • A Novel Two-Stage, Transdisciplinary Study Identifies Digoxin as a Possible Drug for Prostate Cancer Treatment 

      Platz, Elizabeth A.; Yegnasubramanian, Srinivasan; Liu, Jun O.; Chong, Curtis R.; Shim, Joong Sup; Kenfield, Stacey A.; Stampfer, Meir; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Giovannucci, Edward; Nelson, William G. (American Association for Cancer Research, 2011)
      Identification of novel indications for commonly prescribed drugs could accelerate translation of therapies. We investigated whether any clinically used drugs might be useful in treating prostate cancer by coupling an ...
    • A Pooled Analysis of 14 Cohort Studies of Anthropometric Factors and Pancreatic Cancer Risk 

      Genkinger, Jeanine M.; Spiegelman, Donna; Anderson, Kristin E.; Bernstein, Leslie; Brandt, Piet den; Calle, Eugenia E.; English, Dallas R.; Folsom, Aaron R.; Freudenheim, Jo L.; Fuchs, Charles S.; Giles, Graham G.; Giovannucci, Edward; Horn-Ross, Pamela L.; Larsson, Susanna C.; Leitzmann, Michael; Männistö, Satu; Marshall, James R.; Miller, Anthony B.; Patel, Alpa V.; Rohan, Thomas E.; Stolzenberg-Solomon, Rachael Z.; Verhage, Bas A. J.; Virtamo, Jarmo; Willcox, Bradley J.; Wolk, Alicja; Ziegler, Regina G.; Smith-Warner, Stephanie A. (Wiley, 2011)
      Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. ...
    • A profile of impaired insulin degradation in relation to late-life cognitive decline: A preliminary investigation 

      Okereke, Olivia I.; Selkoe, Dennis J.; Pollak, Michael N.; Stampfer, Meir; Hu, Frank B.; Hankinson, Susan E.; Grodstein, Francine (Wiley, 2009)
      Objective Insulin degradation pathways may be related to Alzheimer's disease pathology. In preliminary analyses, we considered the relation of combined lower insulin secretion (c-peptide) and higher insulin-possibly a ...
    • A prospective analysis of blood donation history and risk of non-Hodgkin lymphoma 

      Ishii, Kazusa; Birmann, Brenda; Zhang, Xuehong; Giovannucci, Edward; Bertrand, Kimberly (Taylor & Francis, 2016)
      Blood donation may influence subsequent NHL development via temporary immune system alterations. To test the hypothesis that frequent blood donation is associated with an increased risk of NHL and its most common histologic ...
    • A prospective cohort study of endometriosis and subsequent risk of infertility 

      Prescott, J.; Farland, L. V.; Tobias, D. K.; Gaskins, A. J.; Spiegelman, D.; Chavarro, J. E.; Rich-Edwards, J. W.; Barbieri, R. L.; Missmer, S. A. (Oxford University Press, 2016)
      STUDY QUESTION: Is there a temporal relationship between endometriosis and infertility? SUMMARY ANSWER: Endometriosis is associated with a higher risk of subsequent infertility, but only among women age <35 years. WHAT ...
    • A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers 

      Nosho, Katsuhiko; Kure, Shoko; Irahara, Natsumi; Shima, Kaori; Baba, Yoshifumi; Spiegelman, Donna; Meyerhardt, Jeffrey A.; Giovannucci, Edward L.; Fuchs, Charles S.; Ogino, Shuji (Elsevier, 2009)
      BACKGROUND and AIMS: Synchronous colorectal neoplasias (2 or more primary carcinomas identified in the same patient) are caused by common generic and environmental factors and can be used to study the field effect. Synchronous ...
    • A Prospective Investigation of PTEN Loss and ERG Expression in Lethal Prostate Cancer 

      Ahearn, Thomas; Pettersson, Andreas; Ebot, Ericka; Gerke, Travis; Graff, Rebecca; Morais, Carlos; Hicks, Jessica; Wilson, Kathryn; Rider, Jennifer; Sesso, Howard; Fiorentino, Michelangelo; Flavin, Richard; Finn, Stephen; Giovannucci, Edward; Loda, Massimo; Stampfer, Meir; De Marzo, Angelo M.; Mucci, Lorelei; Lotan, Tamara (Oxford University Press, 2016)
      Background: PTEN is a tumor suppressor frequently deleted in prostate cancer that may be a useful prognostic biomarker. However, the association of PTEN loss with lethal disease has not been tested in a large, predominantly ...
    • A Prospective Study of Age and Lifestyle Factors in Relation to Community-Acquired Pneumonia in US Men and Women 

      Baik, Inkyung; Curhan, Gary C.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Bendich, Adrianne; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Fawzi, Wafaie W. (American Medical Association, 2000)
    • A Prospective Study of Aspirin Use and the Risk of Pancreatic Cancer in Women 

      Schernhammer, E. S.; Kang, J.-H.; Chan, A. T.; Michaud, D. S.; Skinner, H. G.; Giovannucci, E.; Colditz, G. A.; Fuchs, C. S. (Oxford University Press, 2004)
      Background: In vitro experiments and limited animal studies suggest that aspirin and nonsteroidal anti-inflammatory drugs may inhibit pancreatic carcinogenesis. Because few studies have examined the association between ...
    • A Prospective Study of Breakfast Eating and Incident Coronary Heart Disease in a Cohort of Male U.S. Health Professionals 

      Cahill, Leah E.; Chiuve, Stephanie E.; Mekary, Rania A.; Jensen, Majken K.; Flint, Alan J.; Hu, Frank B.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600 (American Heart Association, 2013)
      Background: Among adults, skipping meals is associated with excess body weight, hypertension, insulin resistance, and elevated fasting lipid concentrations. However, it remains unknown whether specific eating habits ...
    • A prospective study of calcium intake from diet and supplements and risk of ischemic heart disease among men 

      Al-Delaimy, Wael K.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Stampfer, Meir; Hu, Frank B. (Oxford University Press, 2003)
      Background: Calcium intake is thought to have a protective effect on the risk of developing ischemic heart disease (IHD), but the existing data are inconsistent. Objective: The objective was to assess the relation between ...
    • A prospective study of carotenoid intake and risk of cataract extraction in US men 

      Brown, L.; Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600; Seddon, J. M.; Giovannucci, E. L.; Chasan-Taber, L.; Spiegelman, D.; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Hankinson, S. E. (Oxford University Press, 1999)
      Background: Dietary antioxidants, including carotenoids, are hypothesized to decrease the risk of age-related cataracts by preventing oxidation of proteins or lipids within the lens. However, prospective epidemiologic data ...
    • A Prospective Study of Childhood and Adult Socioeconomic Status and Incidence of Type 2 Diabetes in Women 

      Lidfeldt, J.; Li, T. Y.; Hu, F. B.; Manson, J. E.; Kawachi, I. (, 2007)
      The influence of childhood socioeconomic status (SES) on incidence of type 2 diabetes mellitus has not previously been studied. The authors prospectively examined the association of childhood SES (father's occupation) with ...
    • A prospective study of dietary fat consumption and endometriosis risk 

      Missmer, Stacey A.; Chavarro, Jorge E.; Malspeis, Susan; Bertone-Johnson, Elizabeth R.; Hornstein, Mark D.; Spiegelman, Donna; Barbieri, Robert L.; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600; Hankinson, Susan E. (Oxford University Press, 2010)
      Background: Endometriosis is a prevalent but enigmatic gynecologic disorder for which few modifiable risk factors have been identified. Fish oil consumption has been associated with symptom improvement in studies of women ...
    • A Prospective Study of Dietary Fiber Types and Symptomatic Diverticular Disease in Men 

      Aldoori, W. H.; Giovannucci, E. L.; Rockett, H. R.; Sampson, L.; Rimm, Eric; Willett, Walter C.::94559ea206eef8a8844fc5b80654fa5b::600 (Oxford University Press, 1998)
    • A Prospective Study of Duration of Smoking Cessation and Colorectal Cancer Risk by Epigenetics-related Tumor Classification 

      Nishihara, Reiko; Morikawa, Teppei; Kuchiba, Aya; Lochhead, Paul; Yamauchi, Mai; Liao, Xiaoyun; Imamura, Yu; Nosho, Katsuhiko; Shima, Kaori; Kawachi, Ichiro; Qian, Zhi Rong; Fuchs, Charles S.; Chan, Andrew T.; Giovannucci, Edward; Ogino, Shuji (, 2013)
      The effect of duration of cigarette smoking cessation on colorectal cancer risk by molecular subtypes remains unclear. Using duplication-method Cox proportional-hazards regression analyses, we examined associations between ...
    • A Prospective study of Endometriosis and Risk of Benign Breast Disease 

      Farland, Leslie; Tamimi, Rulla; Eliassen, A. Heather; Spiegelman, Donna; Collins, Laura; Schnitt, Stuart; Missmer, Stacey (Springer (part of Springer Nature), 2016)
      Given the altered hormonal and inflammatory environment of women with endometriosis, several studies have suggested a positive association between endometriosis and breast cancer, although findings have been mixed. This ...
    • A prospective study of Epstein-Barr virus antibodies and risk of non-Hodgkin lymphoma 

      Bertrand, Kimberly A.; Birmann, Brenda M.; Chang, Ellen T.; Spiegelman, Donna; Aster, Jon C.; Zhang, Shumin M.; Laden, Francine (American Society of Hematology, 2010)
      Severe immunosuppression is an established risk factor for non-Hodgkin lymphoma (NHL), but an association with subclinical immune dysfunction is unclear. We conducted a case-control study nested in the Physicians' Health ...
    • A prospective study of genetic polymorphisms in the cytochrome P-450 2C9 enzyme and the risk for distal colorectal adenoma 

      Chan, Andrew T.; Tranah, Gregory J.; Giovannucci, Edward L.; Hunter, David J.; Fuchs, Charles S. (Elsevier, 2004)
      Background: & Aims: Regular aspirin use is associated with a reduced risk for colorectal adenoma, whereas smoking increases risk. The cytochrome P-450 (CYP) 2C9 (CYP2C9) enzyme is involved in the metabolism of several ...