Now showing items 5738-5757 of 6362

    • Switching HIV Treatment in Adults Based on CD4 Count Versus Viral Load Monitoring: A Randomized, Non-Inferiority Trial in Thailand 

      Jourdain, Gonzague; Le Cœur, Sophie; Ngo-Giang-Huong, Nicole; Traisathit, Patrinee; Cressey, Tim R.; Fregonese, Federica; Leurent, Baptiste; Collins, Intira J.; Techapornroong, Malee; Banchongkit, Sukit; Buranabanjasatean, Sudanee; Halue, Guttiga; Nilmanat, Ampaipith; Luekamlung, Nuananong; Klinbuayaem, Virat; Chutanunta, Apichat; Kantipong, Pacharee; Bowonwatanuwong, Chureeratana; Lertkoonalak, Rittha; Leenasirimakul, Prattana; Tansuphasawasdikul, Somboon; Sang-a-gad, Pensiriwan; Pathipvanich, Panita; Thongbuaban, Srisuda; Wittayapraparat, Pakorn; Eiamsirikit, Naree; Buranawanitchakorn, Yuwadee; Yutthakasemsunt, Naruepon; Winiyakul, Narong; Decker, Luc; Barbier, Sylvaine; Koetsawang, Suporn; Sirirungsi, Wasna; McIntosh, Kenneth; Thanprasertsuk, Sombat; Lallemant, Marc (Public Library of Science, 2013)
      Background: Viral load (VL) is recommended for monitoring the response to highly active antiretroviral therapy (HAART) but is not routinely available in most low- and middle-income countries. The purpose of the study was ...
    • Symptoms of anxiety and risk of coronary heart disease. The Normative Aging Study 

      Kawachi, I.; Sparrow, D.; Vokonas, P. S.; Weiss, S. T. (, 1994)
      Background Several studies have suggested an increased risk of fatal coronary heart disease (CHD) among patients with panic disorder, phobic anxiety, and other anxiety disorders. We prospectively examined this association ...
    • Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases 

      Yang, Jialiang; Huang, Tao; Petralia, Francesca; Long, Quan; Zhang, Bin; Argmann, Carmen; Zhao, Yong; Mobbs, Charles V.; Schadt, Eric E.; Zhu, Jun; Tu, Zhidong; Ardlie, Kristin G.; Deluca, David S.; Segrè, Ayellet V.; Sullivan, Timothy J.; Young, Taylor R.; Gelfand, Ellen T.; Trowbridge, Casandra A.; Maller, Julian B.; Tukiainen, Taru; Lek, Monkol; Ward, Lucas D.; Kheradpour, Pouya; Iriarte, Benjamin; Meng, Yan; Palmer, Cameron D.; Winckler, Wendy; Hirschhorn, Joel; Kellis, Manolis; MacArthur, Daniel G.; Getz, Gad; Shablin, Andrey A.; Li, Gen; Zhou, Yi-Hui; Nobel, Andrew B.; Rusyn, Ivan; Wright, Fred A.; Lappalainen, Tuuli; Ferreira, Pedro G.; Ongen, Halit; Rivas, Manuel A.; Battle, Alexis; Mostafavi, Sara; Monlong, Jean; Sammeth, Michael; Mele, Marta; Reverter, Ferran; Goldman, Jakob; Koller, Daphne; Guigo, Roderic; McCarthy, Mark I.; Dermitzakis, Emmanouil T.; Gamazon, Eric R.; Konkashbaev, Anuar; Nicolae, Dan L.; Cox, Nancy J.; Flutre, Timothée; Wen, Xiaoquan; Stephens, Matthew; Pritchard, Jonathan K.; Lin, Luan; Liu, Jun; Brown, Amanda; Mestichelli, Bernadette; Tidwell, Denee; Lo, Edmund; Salvatore, Mike; Shad, Saboor; Thomas, Jeffrey A.; Lonsdale, John T.; Choi, Christopher; Karasik, Ellen; Ramsey, Kimberly; Moser, Michael T.; Foster, Barbara A.; Gillard, Bryan M.; Syron, John; Fleming, Johnelle; Magazine, Harold; Hasz, Rick; Walters, Gary D.; Bridge, Jason P.; Miklos, Mark; Sullivan, Susan; Barker, Laura K.; Traino, Heather; Mosavel, Magboeba; Siminoff, Laura A.; Valley, Dana R.; Rohrer, Daniel C.; Jewel, Scott; Branton, Philip; Sobin, Leslie H.; Qi, Liqun; Hariharan, Pushpa; Wu, Shenpei; Tabor, David; Shive, Charles; Smith, Anna M.; Buia, Stephen A.; Undale, Anita H.; Robinson, Karna L.; Roche, Nancy; Valentino, Kimberly M.; Britton, Angela; Burges, Robin; Bradbury, Debra; Hambright, Kenneth W.; Seleski, John; Korzeniewski, Greg E.; Erickson, Kenyon; Marcus, Yvonne; Tejada, Jorge; Taherian, Mehran; Lu, Chunrong; Robles, Barnaby E.; Basile, Margaret; Mash, Deborah C.; Volpi, Simona; Struewing, Jeff; Temple, Gary F.; Boyer, Joy; Colantuoni, Deborah; Little, Roger; Koester, Susan; Carithers, NCI Latarsha J.; Moore, Helen M.; Guan, Ping; Compton, Carolyn; Sawyer, Sherilyn J.; Demchok, Joanne P.; Vaught, Jimmie B.; Rabiner, Chana A.; Lockhart, Nicole C. (Nature Publishing Group, 2015)
      Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic changes in tissues across the whole body can provide valuable ...
    • Synchrotron x-ray imaging of pulmonary alveoli in respiration in live intact mice 

      Chang, Soeun; Kwon, Namseop; Kim, Jinkyung; Kohmura, Yoshiki; Ishikawa, Tetsuya; Rhee, Chin Kook; Je, Jung Ho; Tsuda, Akira (Nature Publishing Group, 2015)
      Despite nearly a half century of studies, it has not been fully understood how pulmonary alveoli, the elementary gas exchange units in mammalian lungs, inflate and deflate during respiration. Understanding alveolar dynamics ...
    • Synergistic effects of neck circumference and metabolic risk factors on insulin resistance: the Cardiometabolic Risk in Chinese (CRC) study 

      Liang, Jun; Teng, Fei; Liu, Xuekui; Zou, Caiyan; Wang, Yu; Dou, Lianjun; Sun, Zilin; Qi, Lu (BioMed Central, 2014)
      Objectives: Recent studies have associated neck circumference (NC) with insulin resistance (IR). We examined whether such relation was modified by other metabolic risk factors. Methods: The study samples were from a ...
    • Synergistic Effects of Serum Uric Acid and Cardiometabolic Risk Factors on Early Stage Atherosclerosis: The Cardiometabolic Risk in Chinese Study 

      Liang, Jun; Li, Yanping; Zhou, Na; Teng, Fei; Zhao, Jing; Zou, Caiyan; Qi, Lu (Public Library of Science, 2012)
      Objective: To comprehensively examine the associations of serum uric acid (SUA) with central and peripheral arterial stiffness in Chinese adults, and particularly assess the interactions between SUA and other cardiometabolic ...
    • Synergistic effects of traffic-related air pollution and exposure to violence on urban asthma etiology 

      Clougherty, Jane E.; Levy, Jonathan Ian; Kubzansky, Laura Diane; Ryan, P. Barry; Suglia, Shakira Franco; Canner, Marina Jacobson; Wright, Rosalind Jo (National Institute of Environmental Health Sciences, 2007)
      Background: Disproportionate life stress and consequent physiologic alteration (i.e., immune dysregulation) has been proposed as a major pathway linking socioeconomic position, environmental exposures, and health disparities. ...
    • Syphilis and Hepatitis B Co-infection among HIV-Infected, Sex-Trafficked Women and Girls, Nepal 

      Silverman, Jay Glen; Decker, Michele R.; Gupta, Jhumka; Dharmadhikari, Ashwin; Seage, George R.; Raj, Anita (Centers for Disease Control and Prevention, 2008)
      Sex trafficking may play a major role in spread of HIV across South Asia. We investigated co-infection with HIV and other sexually transmitted diseases among 246 sex-trafficked women and girls from Nepal. Those who were ...
    • Syphilis Predicts HIV Incidence Among Men and Transgender Women Who Have Sex With Men in a Preexposure Prophylaxis Trial 

      Solomon, Marc M.; Mayer, Kenneth H.; Glidden, David V.; Liu, Albert Y.; McMahan, Vanessa M.; Guanira, Juan V.; Chariyalertsak, Suwat; Fernandez, Telmo; Grant, Robert M.; Bekker, Linda-Gail; Buchbinder, Susan; Casapia, Martin; Guanira, Juan; Kallas, Esper; Lama, Javier; Mayer, Kenneth; Montoya, Orlando; Schechter, Mauro; Veloso, Valdiléa (Oxford University Press, 2014)
      Background. Syphilis infection may potentiate transmission of human immunodeficiency virus (HIV). We sought to determine the extent to which HIV acquisition was associated with syphilis infection within an HIV preexposure ...
    • A System for Household Enumeration and Re-identification in Densely Populated Slums to Facilitate Community Research, Education, and Advocacy 

      Thomson, Dana R.; Shitole, Shrutika; Shitole, Tejal; Sawant, Kiran; Subbaraman, Ramnath; Bloom, David E.; Patil-Deshmukh, Anita (Public Library of Science, 2014)
      Background: We devised and implemented an innovative Location-Based Household Coding System (LBHCS) appropriate to a densely populated informal settlement in Mumbai, India. Methods and Findings: LBHCS codes were designed ...
    • Systematic analysis of funding awarded for antimicrobial resistance research to institutions in the UK, 1997–2010 

      Head, Michael G.; Fitchett, Joseph R.; Cooke, Mary K.; Wurie, Fatima B.; Atun, Rifat; Hayward, Andrew C.; Holmes, Alison; Johnson, Alan P.; Woodford, Neil (Oxford University Press, 2013)
      Objectives: To assess the level of research funding awarded to UK institutions specifically for antimicrobial resistance-related research and how closely the topics funded relate to the clinical and public health burden ...
    • Systematic analysis of funding awarded for mycology research to institutions in the UK, 1997–2010 

      Head, Michael G; Fitchett, Joseph R; Atun, Rifat; May, Robin C (BMJ Publishing Group, 2014)
      Objectives: Fungal infections cause significant global morbidity and mortality. We have previously described the UK investments in global infectious disease research, and here our objective is to describe the investments ...
    • Systematic analysis of funding awarded to institutions in the United Kingdom for infectious disease research, 1997–2010 

      Head, Michael G; Fitchett, Joseph R; Moore, David AJ; Atun, Rifat (SAGE Publications, 2015)
      Summary Objectives: This study aimed to assess the research investments made to UK institutions for all infectious disease research and identify the direction of spend by institution. Design: Systematic analysis. Databases ...
    • Systematic analysis of protein identity between Zika virus and other arthropod-borne viruses 

      Chang, Hsiao-Han; Huber, Roland G; Bond, Peter J; Grad, Yonatan Hagai; Camerini, David; Maurer-Stroh, Sebastian; Lipsitch, Marc (WHO Press, 2017)
    • A systematic approach identifies FOXA1 as a key factor in the loss of epithelial traits during the epithelial-to-mesenchymal transition in lung cancer 

      Wang, Haiyun; Meyer, Clifford A; Fei, Teng; Wang, Gang; Zhang, Fan; Liu, X Shirley (BioMed Central, 2013)
      Background: The epithelial-to-mesenchymal transition is an important mechanism in cancer metastasis. Although transcription factors including SNAIL, SLUG, and TWIST1 regulate the epithelial-to-mesenchymal transition, other ...
    • Systematic Curation of miRBase Annotation Using Integrated Small RNA High-Throughput Sequencing Data for C. elegans and Drosophila 

      Wang, Xiangfeng; Liu, Xiaole Shirley (Frontiers Research Foundation, 2011)
      MicroRNAs (miRNAs) are a class of 20–23 nucleotide small RNAs that regulate gene expression post-transcriptionally in animals and plants. Annotation of miRNAs by the miRNA database (miRBase) has largely relied on computational ...
    • Systematic Evaluation of Factors Influencing ChIP-Seq Fidelity 

      Negre, Nicolas; Li, Qunhua; Mieczkowska, Joanna O.; Slattery, Matthew; Kim, Tae-Kyung; Zieba, Jennifer; Ruan, Yijun; Bickel, Peter J.; Wold, Barbara J.; Lieb, Jason D.; Chen, Yiwen; Liu, Tao; Zhang, Yong; He, Housheng H; Myers, Richard M.; White, Kevin P.; Liu, Xiaole Shirley (Nature Publishing Group, 2012)
      We performed a systematic evaluation of how variations in sequencing depth and other parameters influence interpretation of Chromatin immunoprecipitation (ChIP) followed by sequencing (ChIP-seq) experiments. Using Drosophila ...
    • Systematic genetic nomenclature for type VII secretion systems 

      Bitter, Wilbert; Houben, Edith N. G.; Bottai, Daria; Brodin, Priscille; Cox, Jeffery S.; Derbyshire, Keith; Gao, Lian-Yong; Gey van Pittius, Nicolaas C.; Pym, Alexander S.; Cole, Stewart T.; Brosch, Roland; Rall, Glenn F.; Brown, Eric J.; Fortune, Sarah Merritt; Liu, Jun; Rubin, Eric Joseph; Sherman, David R. (Public Library of Science, 2009)
    • Systematic Investigation of Global Coordination among mRNA and Protein in Cellular Society 

      Wang, Haiyun; Shen, Bairong; Huang, Jianhua; Wang, Qi; Pape, Utz Johann; Wu, Bin; Li, Xia (BioMed Central, 2010)
      Background: Cell functions depend on molecules organized in the cellular society. Two basic components are mRNA molecules and proteins. The interactions within and between those two components are crucial for carrying out ...
    • A Systematic Map of Genetic Variation in Plasmodium falciparum 

      Kidgell, Claire; Daily, Johanna; Borevitz, Justin O; Plouffe, David; Zhou, Yingyao; Le Roch, Karine G.; Ndir, Omar; Mboup, Soulyemane; Batalov, Serge; Winzeler, Elizabeth A; Volkman, Sarah K.; Johnson, Jeffrey R.; Sarr, Ousmane; Wirth, Dyann Fergus (Public Library of Science, 2006)
      Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in the development of new ...