Now showing items 1-4 of 4

    • COMMUNICATING THE PARAMETER UNCERTAINTY IN THE IQWIG EFFICIENCY FRONTIER TO DECISION-MAKERS 

      Stollenwerk, Björn; Lhachimi, Stefan K; Briggs, Andrew; Fenwick, Elisabeth; Caro, Jaime J; Siebert, Uwe; Danner, Marion; Gerber-Grote, Andreas (John Wiley & Sons, Ltd, 2014)
      The Institute for Quality and Efficiency in Health Care (IQWiG) developed—in a consultation process with an international expert panel—the efficiency frontier (EF) approach to satisfy a range of legal requirements for ...
    • The Effect of Dose and Timing of Dose on the Association between Airborne Particles and Survival 

      Schwartz, Joel David; Coull, Brent Andrew; Laden, Francine; Ryan, Louise Marie (2008)
      BACKGROUND: Understanding the shape of the concentration–response curve for particles is important for public health, and lack of such understanding was recently cited by U.S. Environmental Protection Agency (EPA) as a ...
    • An ignored risk factor in toxicology: The total imprecision of exposure assessment 

      Grandjean, Philippe; Budtz-Jørgensen, Esben (Walter de Gruyter GmbH, 2010)
      Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. ...
    • Paracelsus Revisited: The Dose Concept in a Complex World 

      Grandjean, Philippe (Wiley-Blackwell, 2016)
      At the time that Paracelsus coined his famous dictum, “What is there that is not poison? All things are poison and nothing is without poison. Solely the dose determines that a thing is not a poison,” embryonic toxicology ...