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    • Evidence for Soft Selective Sweeps in the Evolution of Pneumococcal Multidrug Resistance and Vaccine Escape 

      Croucher, Nicholas J.; Chewapreecha, Claire; Hanage, William P.; Harris, Simon R.; McGee, Lesley; van der Linden, Mark; Song, Jae-Hoon; Ko, Kwan Soo; de Lencastre, Herminia; Turner, Claudia; Yang, Fan; Sá-Leão, Raquel; Beall, Bernard; Klugman, Keith P.; Parkhill, Julian; Turner, Paul; Bentley, Stephen D. (Oxford University Press, 2014)
      The multidrug-resistant Streptococcus pneumoniae Taiwan19F-14, or PMEN14, clone was first observed with a 19F serotype, which is targeted by the heptavalent polysaccharide conjugate vaccine (PCV7). However, “vaccine escape” ...